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Risk Management for BRCA1/BRCA2 Mutation Carriers Without and With Breast Cancer

Risk Management for BRCA1/BRCA2 Mutation Carriers Without and With Breast Cancer Purpose of ReviewWe review the management for unaffected BRCA1/2 mutation carriers and the local management of early-stage breast cancer.Recent FindingsFor unaffected BRCA1/2 mutation carriers, surveillance includes annual magnetic resonance imaging (MRI) and mammogram (MG). Novel imaging modalities, including abbreviated protocol MRI, ultrafast/accelerated MRI, and contrast-enhanced digital mammography are being investigated. Risk-reducing mastectomy (RRM) should be considered, and nipple-areolar sparing mastectomy (NSM) is now an option. Additionally, risk-reducing salpingo-oophorectomy (RRSO) is strongly recommended as it reduces mortality. In BRCA1/2 mutation carriers with breast cancer, BCT is an appropriate treatment option but to reduce risk of second primary, mastectomy and contralateral risk-reducing mastectomy should be considered.SummaryBreast and ovarian cancer screening and prevention options result in improved outcomes and decreased mortality in BRCA1/2 mutation carriers. In women with BRCA1/2 mutations who have BC, local management of the BC and secondary surgical prevention measures are different than women with sporadic disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Breast Cancer Reports Springer Journals

Risk Management for BRCA1/BRCA2 Mutation Carriers Without and With Breast Cancer

Mainor, C. B.; Isaacs, C.
Current Breast Cancer Reports , Volume 12 (2) – Jun 17, 2020
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Publisher
Springer Journals
Copyright
Copyright © Springer Science+Business Media, LLC, part of Springer Nature 2020
ISSN
1943-4588
eISSN
1943-4596
DOI
10.1007/s12609-019-00350-2
Publisher site
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Abstract

Purpose of ReviewWe review the management for unaffected BRCA1/2 mutation carriers and the local management of early-stage breast cancer.Recent FindingsFor unaffected BRCA1/2 mutation carriers, surveillance includes annual magnetic resonance imaging (MRI) and mammogram (MG). Novel imaging modalities, including abbreviated protocol MRI, ultrafast/accelerated MRI, and contrast-enhanced digital mammography are being investigated. Risk-reducing mastectomy (RRM) should be considered, and nipple-areolar sparing mastectomy (NSM) is now an option. Additionally, risk-reducing salpingo-oophorectomy (RRSO) is strongly recommended as it reduces mortality. In BRCA1/2 mutation carriers with breast cancer, BCT is an appropriate treatment option but to reduce risk of second primary, mastectomy and contralateral risk-reducing mastectomy should be considered.SummaryBreast and ovarian cancer screening and prevention options result in improved outcomes and decreased mortality in BRCA1/2 mutation carriers. In women with BRCA1/2 mutations who have BC, local management of the BC and secondary surgical prevention measures are different than women with sporadic disease.

Journal

Current Breast Cancer Reports – Springer Journals

Published: Jun 17, 2020

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