Retinoid signalling and axial patterning during early vertebrate embryogenesis

Retinoid signalling and axial patterning during early vertebrate embryogenesis Abstract There are many indications that active retinoids are regulatory signals during vertebrate embryogenesis. Treating vertebrate embryos with retinoids can cause teratogenic defects, including specific derangements of the main body axis. Other data show that early vertebrate embryos contain physiologically relevant concentrations of active retinoids and express retinoid binding proteins and receptors; that knockouts of retinoid receptors can induce homeotic defects; and that relevant developmental control genes are regulated by retinoid response elements. Here, we discuss the possibility that retinoids are developmental signals which regulate axial patterning in the early vertebrate embryo. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cellular and Molecular Life Sciences CMLS Springer Journals

Retinoid signalling and axial patterning during early vertebrate embryogenesis

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Publisher
Springer Journals
Copyright
© Birkhäuser Verlag Basel 1997 © Birkhäuser Verlag Basel 1997
Subject
Life Sciences; Cell Biology; Biomedicine general; Life Sciences, general; Biochemistry, general
ISSN
1420-682X
eISSN
1420-9071
DOI
10.1007/PL00000610
Publisher site
See Article on Publisher Site

Abstract

Abstract There are many indications that active retinoids are regulatory signals during vertebrate embryogenesis. Treating vertebrate embryos with retinoids can cause teratogenic defects, including specific derangements of the main body axis. Other data show that early vertebrate embryos contain physiologically relevant concentrations of active retinoids and express retinoid binding proteins and receptors; that knockouts of retinoid receptors can induce homeotic defects; and that relevant developmental control genes are regulated by retinoid response elements. Here, we discuss the possibility that retinoids are developmental signals which regulate axial patterning in the early vertebrate embryo.

Journal

Cellular and Molecular Life Sciences CMLSSpringer Journals

Published: Apr 1, 1997

Keywords: Key words. Retinoid; Hox gene; Xenopus; retinoid receptor; axial patterning.

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