Reluctance of rats to drink hashish suspensions: Free-choice and forced consumption, and the effects of hypothalamic stimulation

Reluctance of rats to drink hashish suspensions: Free-choice and forced consumption, and the... 213 35 35 2 2 Michael E. Corcoran Zalman Amit Department of Psychology McGill University Canada Kinsmen Laboratory of Neurological Research, Department of Psychiatry The University of British Columbia Vancouver 8 Canada Sir George Williams University Montreal P.Q. Abstract For over 30 days male Wistar rats drank a concentrated aqueous suspension of hashish in the absence of alternative fluids, but they rejected the drug when water was also made available. In another experiment rats given a choice between water and varying concentrations of hashish also rejected concentrated suspensions, but they appeared less reluctant to drink dilute concentrations. Neither a schedule of alternate-day presentation of hashish nor forced electrical stimulation of lateral hypothalamus induced rats to increase their home-cage intake of an aversive concentration of hashish, suggesting that the enhanced consumption of concentrated ethanol solutions obtained with these two procedures is not due to a nonspecific tendency to ingest any drug offered. Thus rats are generally reluctant to self-administer hashish via the oral route, and their reluctance is not affected by several procedures which can increase their intake of other drugs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Reluctance of rats to drink hashish suspensions: Free-choice and forced consumption, and the effects of hypothalamic stimulation

Psychopharmacology, Volume 35 (2) – Jun 1, 1974

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Publisher
Springer Journals
Copyright
Copyright © 1974 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/BF00429580
Publisher site
See Article on Publisher Site

Abstract

213 35 35 2 2 Michael E. Corcoran Zalman Amit Department of Psychology McGill University Canada Kinsmen Laboratory of Neurological Research, Department of Psychiatry The University of British Columbia Vancouver 8 Canada Sir George Williams University Montreal P.Q. Abstract For over 30 days male Wistar rats drank a concentrated aqueous suspension of hashish in the absence of alternative fluids, but they rejected the drug when water was also made available. In another experiment rats given a choice between water and varying concentrations of hashish also rejected concentrated suspensions, but they appeared less reluctant to drink dilute concentrations. Neither a schedule of alternate-day presentation of hashish nor forced electrical stimulation of lateral hypothalamus induced rats to increase their home-cage intake of an aversive concentration of hashish, suggesting that the enhanced consumption of concentrated ethanol solutions obtained with these two procedures is not due to a nonspecific tendency to ingest any drug offered. Thus rats are generally reluctant to self-administer hashish via the oral route, and their reluctance is not affected by several procedures which can increase their intake of other drugs.

Journal

PsychopharmacologySpringer Journals

Published: Jun 1, 1974

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