The current study examined whether stimuli predictive of heroin availability were capable of inducing a relapse of drug-seeking behavior in an operant runway task. Olfactory stimuli (orange and almond food extract) served as discriminative cues about the availability (S+) or unavailability (S–) of heroin reinforcement (a single 0.1 mg/kg IV infusion) in the goal box of a straight arm runway. Following discrimination training, the running response was extinguished in the absence of the olfactory cues. On a single trial, the discriminative stimuli were then tested for their ability to reinstate running behavior prior to presentation of the heroin reinforcer. Subjects presented with the S+ on test day took significantly less time to traverse the alley than they did on the final day of extinction, while those subjects presented with the S– on test day continued to run slowly. These results demonstrate, in an animal model of drug self-administration, that environmental discriminative cues can produce a relapse in drug seeking behavior following a period of abstinence. The response-reinstating properties of the S+ odor were unaltered by pretreatment with any of three doses of haloperidol (0.0, 0.15 or 0.3 mg/kg IP), suggesting that the motivating properties of heroin-predictive stimuli or cues remain intact during dopamine receptor antagonism.
Psychopharmacology – Springer Journals
Published: May 1, 1997
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera