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- Publisher
- Springer Journals
- Copyright
- Copyright © 2002 by Kluwer Academic Publishers
- Subject
- Chemistry; Biotechnology; Organic Chemistry; Bioorganic Chemistry; Biochemistry, general; Microbiology; Animal Anatomy / Morphology / Histology
- ISSN
- 0141-5492
- eISSN
- 1573-6776
- DOI
- 10.1023/A:1015648508146
- Publisher site
- See Article on Publisher Site
Abstract
Candida antarctica B lipase-catalysed alcoholysis of 2′, 3′, 5′-tri-O-hexanoyluridine (1a), 2′, 3′, 5′-tri-O-dodecanoyluridine (1b), 2′, 3′, 5′-tri-O-hexanoylinosine (1c) and 2′, 3′, 5′-tri-O-dodecanoylinosine (1d) proceeded regioselectively to produce the corresponding 2′, 3′-di-O-acylribonucleosides 2a–d, providing a simple and efficient access to these new lipophilic compounds. Contrasting to the alcoholysis, enzymatic hydrolysis of 1a–d using different enzymes and experimental conditions did not proceed regioselectively.
Journal
Biotechnology Letters – Springer Journals
Published: Oct 10, 2004