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Recognition of the fungal cell wall by innate immune receptors

Recognition of the fungal cell wall by innate immune receptors Human cells have a variety of receptors that innately recognize conserved structures on the fungal cell wall. Major receptors include dectin-1, which recognizes β1,3-glucans; mannose receptors, which recognize mannans, and Toll-like receptors 2 and 4. The fungal cell wall is a potent activator of complement, which results in deposition of fragments of the third component of complement that serve as ligands for complement receptors. The nature of the innate immune response is dictated by the relative amount each of these receptors is stimulated. Innate recognition can lead to destruction of the invading fungus and/or initiation of an adaptive immune response. Fungi have a variety of strategies to avoid innate recognition, including masking of ligands and changing their surface properties by phase transition. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Fungal Infection Reports Springer Journals

Recognition of the fungal cell wall by innate immune receptors

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References (47)

Publisher
Springer Journals
Copyright
Copyright © 2009 by Current Medicine Group, LLC
Subject
Medicine & Public Health; Internal Medicine ; Infectious Diseases
ISSN
1936-3761
eISSN
1936-377X
DOI
10.1007/s12281-009-0023-9
Publisher site
See Article on Publisher Site

Abstract

Human cells have a variety of receptors that innately recognize conserved structures on the fungal cell wall. Major receptors include dectin-1, which recognizes β1,3-glucans; mannose receptors, which recognize mannans, and Toll-like receptors 2 and 4. The fungal cell wall is a potent activator of complement, which results in deposition of fragments of the third component of complement that serve as ligands for complement receptors. The nature of the innate immune response is dictated by the relative amount each of these receptors is stimulated. Innate recognition can lead to destruction of the invading fungus and/or initiation of an adaptive immune response. Fungi have a variety of strategies to avoid innate recognition, including masking of ligands and changing their surface properties by phase transition.

Journal

Current Fungal Infection ReportsSpringer Journals

Published: Aug 26, 2009

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