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K. Miyazono, Kiyoshi Kusanagi, Hirofumi Inoue (2001)
Divergence and convergence of TGF‐β/BMP signalingJournal of Cellular Physiology, 187
H. Okada, Yusuke Watanabe, T. Kikuta, Tatsuya Kobayashi, Y. Kanno, T. Sugaya, Hiromichi Suzuki (2004)
Bradykinin decreases plasminogen activator inhibitor-1 expression and facilitates matrix degradation in the renal tubulointerstitium under angiotensin-converting enzyme blockade.Journal of the American Society of Nephrology : JASN, 15 9
L. Dworkin, R. Gong, E. Tolbert, J. Centracchio, N. Yano, A. Zanabli, A. Esparza, A. Rifai (2004)
Hepatocyte growth factor ameliorates progression of interstitial fibrosis in rats with established renal injury.Kidney international, 65 2
S. Gould, M. Day, Simon Jones, H. Dorai (2002)
BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells.Kidney international, 61 1
R. Kalluri, M. Zeisberg (2003)
Exploring the connection between chronic renal fibrosis and bone morphogenic protein-7.Histology and histopathology, 18 1
K. Hruska, G. Guo, M. Woźniak, D. Martin, S. Miller, H. Liapis, Kenneth Loveday, S. Klahr, T. Sampath, Jeremiah Morrissey (2000)
Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction.American journal of physiology. Renal physiology, 279 1
M. Zeisberg, Cindy Bottiglio, Navin Kumar, Y. Maeshima, F. Strutz, G. Müller, R. Kalluri (2003)
Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models.American journal of physiology. Renal physiology, 285 6
J. Oliver, O. Maarouf, F. Cheema, T. Martens, Q. Al-Awqati (2004)
The renal papilla is a niche for adult kidney stem cells.The Journal of clinical investigation, 114 6
Shinong Wang, J. Lapage, R. Hirschberg (2001)
Loss of tubular bone morphogenetic protein-7 in diabetic nephropathy.Journal of the American Society of Nephrology : JASN, 12 11
C Van Kooten, AM Woltman, MR Daha (2000)
Immunological function of tubular epithelial cells: the functional implications of CD40 expressionExp Nephrol, 8
S Vukicevic, V Basic, D Rogic, N Basic, MS Shih, A Shepard (1998)
Osteogenic protein-1 reduces severity of injury after ischemic acute renal failure in ratJ Clin Invest, 102
M. Zeisberg, J. Hanai, H. Sugimoto, T. Mammoto, D. Charytan, F. Strutz, R. Kalluri (2003)
BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injuryNature Medicine, 9
Song Wang, Qing Chen, T. Simon, Frank Strebeck, L. Chaudhary, J. Morrissey, H. Liapis, S. Klahr, K. Hruska (2003)
Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy.Kidney international, 63 6
A. Leask, David Abraham (2004)
TGF‐β signaling and the fibrotic responseThe FASEB Journal, 18
C. Kooten, A. Woltman, M. Daha (2000)
Immunological Function of Tubular Epithelial Cells: The Functional Implications of CD40 ExpressionNephron Experimental Nephrology, 8
G. Luo, C. Hofmann, A. Bronckers, M. Sohocko, A. Bradley, G. Karsenty (1995)
BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.Genes & development, 9 22
K. Flanders (2004)
Smad3 as a mediator of the fibrotic responseInternational Journal of Experimental Pathology, 85
J. Bonventre (2003)
Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure.Journal of the American Society of Nephrology : JASN, 14 Suppl 1
S. Vukicevic, V. Bašić, D. Rogić, N. Bašić, M. Shih, A. Shepard, Donald Jin, B. Dattatreyamurty, W. Jones, H. Dorai, S. Ryan, D. Griffiths, James Maliakal, M. Jelić, Maria Pastorcic, A. Stavljenić, T. Sampath (1998)
Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat.The Journal of clinical investigation, 102 1
R. Ray, K. Wharton (2001)
Twisted Perspective New Insights into Extracellular Modulation of BMP Signaling during DevelopmentCell, 104
G. Remuzzi, T. Bertani (1998)
Pathophysiology of progressive nephropathies.The New England journal of medicine, 339 20
Clin Exp Nephrol (2005) 9:100–101 © Japanese Society of Nephrology 2005 DOI 10.1007/s10157-005-0360-0 REVIEW ARTICLE Hirokazu Okada · Raghu Kalluri Recapitulation of kidney development paradigms by BMP-7 reverses chronic renal injury Received: December 8, 2004 / Accepted: March 25, 2005 Key words Bone morphogenic protein-7 · Fibrogenesis · release of proinflammatory/fibrogenic cytokines from tubu- Epithelial-mesenchymal transition lar epithelial cells, reverses epithelial-mesenchymal transi- tion (EMT), and inhibits renal tubular cell apoptosis, to 3,12,17 restore or repair normal renal architecture. Molecular understanding and the control of chronic renal In relation to EMT, intracellular pathways are, as yet, disease progression still represent a major challenge for only partially identified. BMP-7 binds to the Alk3 and Alk6 scientists and clinicians. A number of recent experimental type I serine/threonine kinase receptors, which function via strategies suggest that improvement of renal function and the phosphorylation of Smad1, Smad5, and Smad8, leading 2–5 architectural integrity is potentially feasible. Chronic to an increase in E-cadherin expression in renal tubular renal diseases are characterized by interstitial fibrosis, 8,18 cells. On the other hand, TGF-b binds to Alk5 receptor which is a morphological and functional predictor tightly and activates Smad2 and Smad3, decreasing the expression linked to the survival
Clinical and Experimental Nephrology – Springer Journals
Published: Jan 1, 2005
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