Quality of drinking water and high incidence rate of esophageal cancer in Golestan province of Iran: a probable link

Quality of drinking water and high incidence rate of esophageal cancer in Golestan province of... Golestan province in north Iran is known to be a high-risk area for esophageal cancer (EC). Of a long list of multiple risk factors, this study focuses on a possible link between the epidemiologic patterns of EC and the anomalous concentration of some ions and elements in the drinking water sources. A total of 183 samples from 45 villages covering a wide range of EC mortality rates are collected and analyzed. The results demonstrate that NO3 −, SO4 2−, Sb, and Sr exceed the recommended maximum concentration level (MCL) in drinking water. This is more prominent in the villages with high esophageal cancer mortality rate, suggesting a possible link between EC incidence and water quality. Se concentration in drinking water increases from low to the high EC areas, a finding contrary to the expected trend. It is concluded that Se deficiency does not play a major role in the etiology of EC in the Golestan province. The statistical results obtained from Mann–Whitney and Kruskal–Wallis tests along with cluster analysis are consistent with the observed trend of EC mortality rate in Golestan province. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Environmental Geochemistry and Health Springer Journals

Quality of drinking water and high incidence rate of esophageal cancer in Golestan province of Iran: a probable link

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Publisher
Springer Journals
Copyright
Copyright © 2011 by Springer Science+Business Media B.V.
Subject
Environment; Environmental Health; Geochemistry; Terrestrial Pollution; Soil Science & Conservation; Environmental Chemistry; Public Health
ISSN
0269-4042
eISSN
1573-2983
DOI
10.1007/s10653-011-9377-3
Publisher site
See Article on Publisher Site

Abstract

Golestan province in north Iran is known to be a high-risk area for esophageal cancer (EC). Of a long list of multiple risk factors, this study focuses on a possible link between the epidemiologic patterns of EC and the anomalous concentration of some ions and elements in the drinking water sources. A total of 183 samples from 45 villages covering a wide range of EC mortality rates are collected and analyzed. The results demonstrate that NO3 −, SO4 2−, Sb, and Sr exceed the recommended maximum concentration level (MCL) in drinking water. This is more prominent in the villages with high esophageal cancer mortality rate, suggesting a possible link between EC incidence and water quality. Se concentration in drinking water increases from low to the high EC areas, a finding contrary to the expected trend. It is concluded that Se deficiency does not play a major role in the etiology of EC in the Golestan province. The statistical results obtained from Mann–Whitney and Kruskal–Wallis tests along with cluster analysis are consistent with the observed trend of EC mortality rate in Golestan province.

Journal

Environmental Geochemistry and HealthSpringer Journals

Published: Mar 19, 2011

References

  • Nitrate in drinking water and the incidence of gastric, esophageal, and brain cancer in Yorkshire, England
    Barrett, JH; Parslow, RC; McKinney, PA; Law, GR; Forman, D
  • Animal species in which N-nitroso compounds induce cancer
    Bogovski, P; Bogovski, S

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