Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Purinergic transmission in the central nervous system

Purinergic transmission in the central nervous system The adenosine 5′-triphosphate (ATP), discovered in 1929 by Karl Lohman, Cyrus Hartwell Fiske, and Yellagaprada SubbaRow, acts as an important extracellular signaling molecule. In the CNS, ATP can be released from synaptic terminals, either on its own or together with other neurotransmitters. After the release from the presynaptic terminals, ATP binds to a plethora of ionotropic and metabotropic receptors, which mediate its action as an excitatory neurotransmitter. Furthermore, ATP also acts as an important mediator in neuronal–glial communications because glial cells are endowed with numerous ATP receptors, which trigger Ca2+ signaling events and membrane currents in both macro and microglia. In addition, ATP can be released from astroglial cells, thereby acting as a mediator of glial–glial and glial–neuronal signaling. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pflügers Archiv European Journal of Physiologyl of Physiology Springer Journals

Purinergic transmission in the central nervous system

Loading next page...
 
/lp/springer-journals/purinergic-transmission-in-the-central-nervous-system-TJLAw640x8

References (75)

Publisher
Springer Journals
Copyright
Copyright © 2006 by Springer-Verlag
Subject
Biomedicine; Human Physiology
ISSN
0031-6768
eISSN
1432-2013
DOI
10.1007/s00424-006-0060-y
pmid
16688467
Publisher site
See Article on Publisher Site

Abstract

The adenosine 5′-triphosphate (ATP), discovered in 1929 by Karl Lohman, Cyrus Hartwell Fiske, and Yellagaprada SubbaRow, acts as an important extracellular signaling molecule. In the CNS, ATP can be released from synaptic terminals, either on its own or together with other neurotransmitters. After the release from the presynaptic terminals, ATP binds to a plethora of ionotropic and metabotropic receptors, which mediate its action as an excitatory neurotransmitter. Furthermore, ATP also acts as an important mediator in neuronal–glial communications because glial cells are endowed with numerous ATP receptors, which trigger Ca2+ signaling events and membrane currents in both macro and microglia. In addition, ATP can be released from astroglial cells, thereby acting as a mediator of glial–glial and glial–neuronal signaling.

Journal

Pflügers Archiv European Journal of Physiologyl of PhysiologySpringer Journals

Published: May 11, 2006

There are no references for this article.