Access the full text.
Sign up today, get DeepDyve free for 14 days.
T Mercantepe, D Unal, J Selli, F Mercantepe, B Unal, TN Karabiyik (2016)
Protective effects of estrogen and bortezomib in kidney tissue of post-menopausal rats: an ultrastructural studyRen Fail, 38
JM Yousef, G Chen, PA Hill, RL Nation, J Li (2011)
Melatonin attenuates colistin-induced nephrotoxicity in ratsAntimicrob Agents Chemother, 55
SJ Isakoff, EL Mayer, L He, TA Traina, LA Carey, KJ Krag, HS Rugo, MC Liu, V Stearns, SE Come, KM Timms, AR Hartman, DR Borger, DM Finkelstein, JE Garber, PD Ryan, EP Winer, PE Goss, LW Ellisen (2015)
TBCRC009: a multicenter phase II clinical trial of platinum monotherapy with biomarker assessment in metastatic triple-negative breast cancerJ Clin Oncol, 33
M Pavkovic, B Riefke, H Ellinger-Ziegelbauer (2014)
Urinary microRNA profiling for identification of biomarkers after cisplatin-induced kidney injuryToxicology, 324
M Sánchez-Hidalgo, JM Guerrero, I Villegas, G Packham, C de la Lastra (2012)
Melatonin, a natural programmed cell death inducer in cancerCurr Med Chem, 19
A-P Beauregard, J Harquail, G Lassalle-Claux, M Belbraouet, J Jean-Francois, M Touaibia, G Robichaud (2015)
CAPE analogs induce growth arrest and apoptosis in breast cancer cellsMolecules, 20
Y Hagos, NA Wolff (2010)
Assessment of the role of renal organic anion transporters in drug-induced nephrotoxicityToxins (Basel), 2
S Faubel, D Ljubanovic, L Reznikov, H Somerset, CA Dinarello, CL Edelstein (2004)
Caspase-1-deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosisKidney Int, 66
LM Greggi Antunes, JDC Darin, LP Bianchi M de (2001)
Effects of the antioxidants curcumin or selenium on cisplatin-induced nephrotoxicity and lipid peroxidation in ratsPharmacol Res, 43
R Rezaee, AA Momtazi, A Monemi, A Sahebkar (2017)
Curcumin: a potentially powerful tool to reverse cisplatin-induced toxicityPharmacol Res, 117
M Nematbakhsh, S Ebrahimian, M Tooyserkani, F Eshraghi-Jazi, A Talebi, F Ashrafi (2013)
Gender difference in cisplatin-induced nephrotoxicity in a rat model: greater intensity of damage in male than femaleNephrourol Mon, 5
M Heung, LS Chawla (2014)
Acute kidney injury: gateway to chronic kidney diseaseNephron Clin Pract, 127
MR Zirak, R Rahimian, M Ghazi-Khansari, A Abbasi, A Razmi, S Ejtemaei Mehr, K Mousavizadeh, AR Dehpour (2014)
Tropisetron attenuates cisplatin-induced nephrotoxicity in miceEur J Pharmacol, 738
N Sreejayan, R MNA, KI Priyadarsini, TPA Devasagayam (1997)
Inhibition of radiation-induced lipid peroxidation by curcuminInt J Pharm, 151
MJ Sung, DH Kim, YJ Jung, KP Kang, AS Lee, S Lee, W Kim, M Davaatseren, JT Hwang, HJ Kim, MS Kim, DY Kwon, SK Park (2008)
Genistein protects the kidney from cisplatin-induced injuryKidney Int, 74
R Domitrović, O Cvijanović, V Šušnić, N Katalinić (2014)
Renoprotective mechanisms of chlorogenic acid in cisplatin-induced kidney injuryToxicology, 324
XIN Yao, K Panichpisal, N Kurtzman (2007)
Cisplatin nephrotoxicity: a reviewAm J Med Sci, 334
K Amirshahrokhi, AR Khalili (2015)
Thalidomide ameliorates cisplatin-induced nephrotoxicity by inhibiting renal inflammation in an experimental modelInflammation, 38
A Ozkok, K Ravichandran, Q Wang, D Ljubanovic, CL Edelstein (2016)
NF-κB transcriptional inhibition ameliorates cisplatin-induced acute kidney injury (AKI)Toxicol Lett, 240
U Pandya, MK Saini, GF Jin, S Awasthi, BF Godley, YC Awasthi (2000)
Dietary curcumin prevents ocular toxicity of naphthalene in ratsToxicol Lett, 115
S Uzunoglu, H Karagol, F Ozpuyan, R Cosar, I Cicin, V Yurutcaloglu, B Denizli, Ö Tanriverdi, N Sut, Z Kocak (2011)
Protective effect of l-carnitine versus amifostine against cisplatin-induced nephrotoxicity in ratsMed Oncol, 28
F Shaki, S Ashari, N Ahangar (2016)
Melatonin can attenuate ciprofloxacin induced nephrotoxicity: involvement of nitric oxide and TNF-αBiomed Pharmacother, 84
M Waseem, P Kaushik, S Parvez (2013)
Mitochondria-mediated mitigatory role of curcumin in cisplatin-induced nephrotoxicityCell Biochem Funct, 31
W Zhang, S Zhang, M Zhang, L Yang, B Cheng, J Li, A Shan (2018)
Individual and combined effects of fusarium toxins on apoptosis in PK15 cells and the protective role of N-acetylcysteineFood Chem Toxicol, 111
D Katagiri, Y Hamasaki, K Doi, K Negishi, T Sugaya, M Nangaku, E Noiri (2016)
Interstitial renal fibrosis due to multiple cisplatin treatments is ameliorated by semicarbazide-sensitive amine oxidase inhibitionKidney Int, 89
Z-N Ma, Z Liu, Z Wang, S Ren, S Tang, YP Wang, SY Xiao, C Chen, W Li (2017)
Supplementation of American ginseng berry extract mitigated cisplatin-evoked nephrotoxicity by suppressing ROS-mediated activation of MAPK and NF-κB signaling pathwaysFood Chem Toxicol, 110
CN Sharp, MA Doll, TV Dupre, PP Shah, M Subathra, D Siow, GE Arteel, J Megyesi, LJ Beverly, LJ Siskind (2016)
Repeated administration of low-dose cisplatin in mice induces fibrosisAm J Physiol Ren Physiol, 310
GR Estrela, F Wasinski, RF Bacurau, DMAC Malheiros, NOS Câmara, RC Araújo (2014)
Kinin B2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injuryInt Immunopharmacol, 22
A Ozkok, CL Edelstein (2014)
Pathophysiology of cisplatin-induced acute kidney injuryBiomed Res Int, 2014
N Pabla, Z Dong (2008)
Cisplatin nephrotoxicity: mechanisms and renoprotective strategiesKidney Int, 73
Y Dilber, S Inan, GA Ercan, A Sencan (2016)
The role of CAPE in PI3K/AKT/mTOR activation and oxidative stress on testis torsionActa Histochem, 118
AY Ahmed, AM Gad, OMA El-Raouf (2017)
Curcumin ameliorates diclofenac sodium-induced nephrotoxicity in male albino ratsJ Biochem Mol Toxicol, 31
I Bougioukas, V Didilis, J Emigholz, R Waldmann-Beushausen, T Stojanovic, C Mühlfeld, FA Schoendube, BC Danner (2016)
The effect of amifostine on lung ischaemia-reperfusion injury in ratsInteract Cardiovasc Thorac Surg, 23
CZ Li, HH Jin, HX Sun, ZZ Zhang, JX Zheng, SH Li, SH Han (2016)
Eriodictyol attenuates cisplatin-induced kidney injury by inhibiting oxidative stress and inflammationEur J Pharmacol, 772
RP Miller, RK Tadagavadi, G Ramesh, WB Reeves (2010)
Mechanisms of cisplatin nephrotoxicityToxins (Basel), 2
Y Ke, X Xu, S Wu, J Huang, Y Geng, H Misra, Y Li (2013)
Protective effects of extracts from Fructus rhodomyrti against oxidative DNA damage in vitro and in vivoOxidative Med Cell Longev, 2013
J Trujillo, E Molina-Jijón, ON Medina-Campos, R Rodríguez-Muñoz, JL Reyes, ML Loredo, D Barrera-Oviedo, E Pinzón, DS Rodríguez-Rangel, J Pedraza-Chaverri (2016)
Curcumin prevents cisplatin-induced decrease in the tight and adherens junctions: relation to oxidative stressFood Funct, 7
G Sener, H Satiroglu, L Kabasakal (2000)
The protective effect of melatonin on cisplatin nephrotoxicityFundam Clin Pharmacol, 14
P Ma, S Zhang, X Su (2015)
Protective effects of icariin on cisplatin-induced acute renal injury in miceAm J Transl Res, 7
S Manohar, N Leung (2017)
Cisplatin nephrotoxicity: a review of the literatureJ Nephrol, 0
SR Pandi-Perumal, AS Bahammam, GM Brown (2013)
Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processesNeurotox Res, 23
VV Prabhu, N Kannan, C Guruvayoorappan (2013)
1,2-Diazole prevents cisplatin-induced Nephrotoxicity in experimental ratsPharmacol Res, 65
F Wang, S Liu, Y Shen (2014)
Protective effects of N-acetylcysteine on cisplatin-induced oxidative stress and DNA damage in HepG2 cellsExp Ther Med, 8
H Ateyya, ZA Hassan, NA El-Sherbeeny (2017)
The selective tyrosine kinase-inhibitor nilotinib alleviates experimentally induced cisplatin nephrotoxicity and heptotoxicityEnviron Toxicol Pharmacol, 55
E Canyilmaz, G Uslu, Z Bahat (2015)
Comparison of the effects of melatonin and genistein on radiation-induced nephrotoxicity: results of an experimental studyBiomed Rep, 4
Y Yang, H Liu, F Liu, Z Dong (2014)
Mitochondrial dysregulation and protection in cisplatin nephrotoxicityArch Toxicol, 88
M-F Chen, C-M Yang, C-M Su, M-L Hu (2014)
Vitamin C protects against cisplatin-induced nephrotoxicity and damage without reducing its effectiveness in C57BL/6 mice xenografted with Lewis lung carcinomaNutr Cancer, 66
R Galgamuwa, K Hardy, JE Dahlstrom, AC Blackburn, E Wium, M Rooke, JY Cappello, P Tummala, HR Patel, A Chuah, L Tian, L McMorrow, PG Board, A Theodoratos (2016)
Dichloroacetate prevents cisplatin-induced nephrotoxicity without compromising cisplatin anticancer propertiesJ Am Soc Nephrol, 27
C Ho, YC Hsu, CC Lei, SC Mau, YH Shih, CL Lin (2016)
Curcumin rescues diabetic renal fibrosis by targeting superoxide-mediated Wnt signaling pathwaysAm J Med Sci, 351
M Nematbakhsh, Z Pezeshki, FE Jazi (2017)
Cisplatin-induced nephrotoxicity; protective supplements and gender differencesAsian Pac J Cancer Prev, 18
R Varatharajan, MZA Sattar, I Chung, MA Abdulla, NM Kassim, NA Abdullah (2013)
Antioxidant and pro-oxidant effects of oil palm (Elaeis guineensis) leaves extract in experimental diabetic nephropathy: a duration-dependent outcomeBMC Complement Altern Med, 13
BI Ognjanović, NZ Djordjević, MM Matić, JM Obradović, JM Mladenović, AŠ Štajn, ZS Saičić (2012)
Lipid peroxidative damage on cisplatin exposure and alterations in antioxidant defense system in rat kidneys: a possible protective effect of seleniumInt J Mol Sci, 13
HA Omar, WR Mohamed, HH Arab, ESA Arafa (2016)
Tangeretin alleviates cisplatin-induced acute hepatic injury in rats: targeting MAPKs and apoptosisPLoS One, 11
N Asna, H Lewy, IE Ashkenazi, V Deutsch, H Peretz, M Inbar, IG Ron (2005)
Time dependent protection of amifostine from renal and hematopoietic cisplatin induced toxicityLife Sci, 76
P Kumar, K Sulakhiya, CC Barua, N Mundhe (2017)
TNF-α, IL-6 and IL-10 expressions, responsible for disparity in action of curcumin against cisplatin-induced nephrotoxicity in ratsMol Cell Biochem, 431
A Khajavi Rad, R Mohebbati, S Hosseinian (2017)
Drug-induced nephrotoxicity and medicinal plantsIran J Kidney Dis, 11
Y Topcu-Tarladacalisir, M Sapmaz-Metin, T Karaca (2016)
Curcumin counteracts cisplatin-induced nephrotoxicity by preventing renal tubular cell apoptosisRen Fail, 38
Z Pezeshki, A Khosravi, M Nekuei, S Khoshnood, E Zandi, M Eslamian, A Talebi, SNED Emami, M Nematbakhsh (2017)
Time course of cisplatin-induced nephrotoxicity and hepatotoxicityJ Nephropathol, 6
M Goudarzi, MJ Khodayar, SMT Hosseini Tabatabaei, H Ghaznavi, I Fatemi, S Mehrzadi (2017)
Pretreatment with melatonin protects against cyclophosphamide-induced oxidative stress and renal damage in miceFundam Clin Pharmacol, 31
Y Xu, H Ma, J Shao, J Wu, L Zhou, Z Zhang, Y Wang, Z Huang, J Ren, S Liu, X Chen, J Han (2015)
A role for tubular necroptosis in cisplatin-induced AKIJ Am Soc Nephrol, 26
MW Helmy, MM Helmy, DM Abd Allah, AM Abo Zaid, MM Mohy el-Din (2014)
Role of nitrergic and endothelin pathways modulations in cisplatin-induced nephrotoxicity in male ratsJ Physiol Pharmacol, 65
MK Kuhlmann, E Horsch, G Burkhardt, M Wagner, H Köhler (1998)
Reduction of cisplatin toxicity in cultured renal tubular cells by the bioflavonoid quercetinArch Toxicol, 72
U Kilic, E Kilic, Z Tuzcu, M Tuzcu, IH Ozercan, O Yilmaz, F Sahin, K Sahin (2013)
Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathwayNutr Metab (Lond), 10
Q Du, C Hao, J Gou (2016)
Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in ratsExp Ther Med, 11
K Ienaga, C Hum Park, T Yokozawa (2014)
Daily hydroxyl radical scavenging capacity of mammalsDrug Discov Ther, 8
H Nasri (2013)
Comment on: a model for prediction of cisplatin induced nephrotoxicity by kidney weight in experimental ratsJ Res Med Sci, 18
J Selli, D Unal, F Mercantepe, N Akaras, R Kabayel, B Unal, H Atilay (2015)
Protective effects of beta glucan in brain tissues of post-menopausal rats: a histochemical and ultra-structural studyGynecol Endocrinol, 3590
S Sheth, D Mukherjea, LP Rybak, V Ramkumar (2017)
Mechanisms of cisplatin-induced ototoxicity and otoprotectionFront Cell Neurosci, 11
L Tumkaya, Y Kalkan, O Bas (2016)
The regenerative effects of electromagnetic field on spinal cord injuryElectromagn Biol Med, 8378
CN Sharp, LJ Siskind (2017)
Developing better mouse models to study cisplatin-induced kidney injuryAm J Physiol Ren Physiol, 313
R Rastghalam, M Nematbakhsh, M Bahadorani, F Eshraghi-Jazi, A Talebi, M Moeini, F Ashrafi, S Shirdavani (2014)
Angiotensin type-1 receptor blockade may not protect kidney against cisplatin-induced nephrotoxicity in ratsISRN Nephrol, 2014
H Ghaznavi, S Mehrzadi, B Dormanesh, SMTH Tabatabaei, H Vahedi, A Hosseinzadeh, HR Pazoki-Toroudi, A Rashidian (2016)
Comparison of the protective effects of melatonin and silymarin against gentamicin-induced nephrotoxicity in ratsJ Evid Based Complementary Altern Med, 21
YC Huang, MS Tsai, PC Hsieh, JH Shih, TS Wang, YC Wang, TH Lin, SH Wang (2017)
Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signalingToxicol Appl Pharmacol, 329
A Kawahara, K Azuma, S Hattori, K Nakashima, Y Basaki, J Akiba, S Takamori, H Aizawa, T Yanagawa, H Izumi, K Kohno, S Kono, M Kage, M Kuwano, M Ono (2010)
The close correlation between 8-hydroxy-2′-deoxyguanosine and epidermal growth factor receptor activating mutation in non-small cell lung cancerHum Pathol, 41
K Sahin, C Orhan, M Tuzcu, I Muqbil, N Sahin, H Gencoglu, O Guler, SB Padhye, FH Sarkar, RM Mohammad (2014)
Comparative in vivo evaluations of curcumin and its analog difluorinated curcumin against cisplatin-induced nephrotoxicityBiol Trace Elem Res, 157
Despite the enormous advances made in the field of oncology, no solution to the side effect of nephrotoxicity caused by cisplatin used as an antineoplastic agent for approximately 40 years has yet been discovered. This study investigated the effects of cisplatin on the kidney, the damage mechanism involved, and the potential capacity of agents such as amifostine, curcumin, and melatonin to elicit a future therapeutic protocol in cisplatin-induced nephrotoxicity at the ultrastructural and molecular levels. Our study consisted of five groups: control (saline solution only; group 1), cisplatin (cisplatin only; group 2), cisplatin + amifostine (group 3), cisplatin + curcumin (group 4), and cisplatin + melatonin (group 5). Rats in all groups except the control group were administered a single intraperitoneal dose of 7.5 mg/kg cisplatin. All animals were sacrificed under anesthesia on the sixth day after cisplatin administration. Cisplatin increased serum urea and serum creatinine levels and caused an increase in tubular necrosis scores (TNS), HPS, NF-κB/p65, 8-OHdG, and caspase-3 expressions (p < 0.05). Additionally, we observed basal membrane thickening in glomerules, intense electron deposition in the subendothelial region, and atypical folds in podocyte pedicels. Amifostine, curcumin, and melatonin reduced the increases in serum urea and serum creatinine levels following cisplatin administration and reduced the levels of TNS, HPS, NF-κB/p65, 8-OHdG, and caspase-3 expressions (p < 0.05). ROS-scavenging antioxidants may be a promising means of preventing acute kidney disease in patients using cisplatin in the treatment of malignant tumors.
Naunyn-Schmiedeberg's Archives of Pharmacology – Springer Journals
Published: Jun 2, 2018
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.