213 121 121 4 4 S. M. Pearl S. D. Glick D. W. Johnson Department of Pharmacology and Neuroscience Albany Medical college 12208 Albany NY USA Department of Physiology University of New England. College of Osteopathic Medicine 04005 Biddefore ME USA Abstract Ibogaine is currently being investigated for its potential use as an anti-addictive agent. In the present study we sought to determine whether prior morphine exposure influences the ability of ibogaine to inhibit morphine-induced locomotor stimulation. Female Sprague-Dawley rats were pretreated once a day for 1–4 days with morphine (5, 10, 20 or 30 mg/kg, IP) or saline and then received ibogaine (40 mg/kg, IP) 5 h after the last morphine pretreatment dose. Compared to rats pretreated with saline, rats pretreated with morphine (10, 20 or 30 mg/kg, IP) before ibogaine (40 mg/kg, IP) showed a significant reduction in morphine-induced (5 mg/kg, IP) locomotor stimulation when tested 19 h after ibogaine administration. Furthermore, this effect was apparent over a range of ibogaine (5–60 mg/kg, IP) and morphine test (2.5–5 mg/kg, IP) dosages. Doses of ibogaine (5 and 10 mg/kg, IP) which alone were inactive inhibited morphine-induced locomotor activity when rats had been pretreated with morphine. These results, showing that morphine pre-exposure affects ibogaine activity, suggest that variable histories of opioid exposure might account for individual differences in the efficacy of ibogaine to inhibit opioid addiction.
Psychopharmacology – Springer Journals
Published: Oct 1, 1995
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