Purpose The present study investigated the preventive effect of the cyclooxygenase (COX)-2 inhibitor, celecoxib, in 7,12-dimethylbenz[a]anthracene (DMBA)-induced ovarian cancer in a rat model. Methods A diet containing celecoxib (1500 ppm) was started 2 weeks before the introduction of DMBA. DMBA-soaked cotton threads were surgically applied to induce ovarian cancer in female Wistar rats. Tumor growth and survival were observed for 24 weeks. Results During the study period, an overall tumor incidence of 97.5% was observed and 65% of tumors were ovarian adeno- carcinoma. The celecoxib diet significantly reduced the incidence and size of DMBA-induced ovarian cancers and signifi - cantly improved survival of tumor-bearing rats. The preventive effect of celecoxib was associated with increased apoptosis. Conclusion DMBA-induced ovarian cancer in rats recapitulates many pathophysiological features of the human counter- part. Our results provide supportive evidence that celecoxib has a preventive effect on development of ovarian cancer in a rat model. Keywords Ovarian cancer · 7, 12-dimethylbenz[a]anthracene (DMBA) · Cyclooxygenase 2 inhibitor · Celecoxib · Survival Abbreviations is key for early detection and development of effective thera - COX Cyclooxygenase pies to improve survival for these patients. DMBA 7,12-Dimethylbenz[a]anthracene Animal models which recapitulate human ovarian can- cer pathophysiological features are important for reveal- ing etiology, and developing
Archives of Gynecology and Obstetrics – Springer Journals
Published: Sep 21, 2018
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