Biochem Genet https://doi.org/10.1007/s10528-018-9865-6 ORIGINAL ARTICLE Preliminary Report on the Association Between STAT3 Polymorphisms and Susceptibility to Acute Kidney Injury After Cardiopulmonary Bypass 1,2 1 3 Sara Aghakhani Chegeni · Mahsa Rahimzadeh · Hossein Montazerghaem · 1 1 3,4 Mahmood Khayatian · Farzaneh Dasturian · Nadereh Naderi Received: 8 January 2018 / Accepted: 18 May 2018 © Springer Science+Business Media, LLC, part of Springer Nature 2018 Abstract Cardiopulmonary bypass-associated acute kidney injury (CPB-AKI) is a well-recognized complication which is clearly linked to increased morbidity and mortality. Due to important role of inflammation in CPB-AKI pathogenesis, we explored the association between polymorphisms in STAT3, an inflammation-asso - ciated transcription factor, and the risk of CPB-AKI. In this study, STAT3 rs1053004 and rs744166 polymorphisms were analyzed in 129 patients undergoing coro- nary artery bypass grafting in Jorjani heart center, Bandar Abbas, Iran. The geno- types were determined using sequence-specific primers (PCR–SSP). Sixty-three patients met the criteria for AKI after cardiac surgery (AKI group). The remaining 66 patients did not develop AKI (non-AKI group). Rs1053004 GG genotype was significantly associated with a decreased risk (OR 0.4, 95% CI 0.17–0.9, P = 0.03) of CPB-AKI. Subgroup analyses revealed that GG genotype has also a protective effect in older patients (Age ≥ 60) (OR 0.19, 95%
Biochemical Genetics – Springer Journals
Published: May 30, 2018
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