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Plasma and CNS pharmacokinetics of O 4 -benzylfolic acid (O 4 BF) and metabolite in a non-human primate model

Plasma and CNS pharmacokinetics of O 4 -benzylfolic acid (O 4 BF) and metabolite in a non-human... Concentrations of O 4 BF and the metabolite in CSF exceeded the ED 50 of AGT; however, recently reported lack of receptor specificity and pharmacokinetic data suggesting saturable elimination of both O 4 BF and its metabolite may limit dose-escalation and future clinical development of this agent. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Chemotherapy and Pharmacology Springer Journals

Plasma and CNS pharmacokinetics of O 4 -benzylfolic acid (O 4 BF) and metabolite in a non-human primate model

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References (20)

Publisher
Springer Journals
Copyright
Copyright © 2011 by Springer-Verlag
Subject
Medicine & Public Health; Oncology; Cancer Research ; Pharmacology/Toxicology
ISSN
0344-5704
eISSN
1432-0843
DOI
10.1007/s00280-010-1407-9
pmid
20725726
Publisher site
See Article on Publisher Site

Abstract

Concentrations of O 4 BF and the metabolite in CSF exceeded the ED 50 of AGT; however, recently reported lack of receptor specificity and pharmacokinetic data suggesting saturable elimination of both O 4 BF and its metabolite may limit dose-escalation and future clinical development of this agent.

Journal

Cancer Chemotherapy and PharmacologySpringer Journals

Published: Jun 1, 2011

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