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Pharmacological and Host Considerations in the Selection of Dose and Duration of Azole Therapy for Adult Patients

Pharmacological and Host Considerations in the Selection of Dose and Duration of Azole Therapy... Azole antifungals are used to treat a myriad of fungal infections in diverse patient populations. As a result, it becomes clear that use of one size fits all azole dosing regimens is illogical. Three general variable categories are essential to consider when developing an approach the management of fungal infections with the azoles. These categories are the pharmacological, microbiological, and host. In the clinical setting information regarding microbiological variables if often lacking; however, host and pharmacological data are abundant. Unfortunately, these available data are not always used to construct individualized dosing strategies. In this review, host and pharmacological factors that can influence azole activity will be presented. Additionally, recommendations will be provided to help the clinician optimize azole dosing regimens based on these variables. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Fungal Infection Reports Springer Journals

Pharmacological and Host Considerations in the Selection of Dose and Duration of Azole Therapy for Adult Patients

Klepser, Michael
Current Fungal Infection Reports , Volume 6 (2) – Apr 28, 2012
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References (44)

Publisher
Springer Journals
Copyright
Copyright © 2012 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Occupational Medicine/Industrial Medicine; Pneumology/Respiratory System; Infectious Diseases; Tropical Medicine; Internal Medicine
ISSN
1936-3761
eISSN
1936-377X
DOI
10.1007/s12281-012-0089-7
Publisher site
See Article on Publisher Site

Abstract

Azole antifungals are used to treat a myriad of fungal infections in diverse patient populations. As a result, it becomes clear that use of one size fits all azole dosing regimens is illogical. Three general variable categories are essential to consider when developing an approach the management of fungal infections with the azoles. These categories are the pharmacological, microbiological, and host. In the clinical setting information regarding microbiological variables if often lacking; however, host and pharmacological data are abundant. Unfortunately, these available data are not always used to construct individualized dosing strategies. In this review, host and pharmacological factors that can influence azole activity will be presented. Additionally, recommendations will be provided to help the clinician optimize azole dosing regimens based on these variables.

Journal

Current Fungal Infection Reports – Springer Journals

Published: Apr 28, 2012

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