Access the full text.
Sign up today, get DeepDyve free for 14 days.
P. Heine, J. Taylor, G. Iwamoto, D. Lubahn, P. Cooke (2000)
Increased adipose tissue in male and female estrogen receptor-alpha knockout mice.Proceedings of the National Academy of Sciences of the United States of America, 97 23
György Csaba, Á. Inczefi-Gonda (2005)
Molecules acting on receptor level at weaning, durably influence liver glucocorticoid receptors.Acta physiologica Hungarica, 92 1
P. White, T. Mune, T. Mune, Anil Agarwal (1997)
11β-Hydroxysteroid Dehydrogenase and the Syndrome of Apparent Mineralocorticoid ExcessEndocrine Reviews, 18
G. Janer, J. Navarro, C. Porte (2007)
Exposure to TBT increases accumulation of lipids and alters fatty acid homeostasis in the ramshorn snail Marisa cornuarietis.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 146 3
G. Cooke (2002)
Effect of organotins on human aromatase activity in vitro.Toxicology letters, 126 2
M. Saitoh, T. Yanase, H. Morinaga, M. Tanabe, Y. Mu, Y. Nishi, M. Nomura, T. Okabe, K. Goto, R. Takayanagi, H. Nawata (2001)
Tributyltin or triphenyltin inhibits aromatase activity in the human granulosa-like tumor cell line KGN.Biochemical and biophysical research communications, 289 1
H. Masuno, T. Kidani, K. Sekiya, K. Sakayama, T. Shiosaka, Haruyasu Yamamoto, K. Honda (2002)
Bisphenol A in combination with insulin can accelerate the conversion of 3T3-L1 fibroblasts to adipocytes.Journal of lipid research, 43 5
Z. Dang, V. Audinot, S. Papapoulos, J. Boutin, C. Löwik (2003)
Peroxisome Proliferator-activated Receptor γ (PPARγ) as a Molecular Target for the Soy Phytoestrogen Genistein*The Journal of Biological Chemistry, 278
R. Taylor, I. Jones, Sheila Williams, A. Goulding (2002)
Body fat percentages measured by dual-energy X-ray absorptiometry corresponding to recently recommended body mass index cutoffs for overweight and obesity in children and adolescents aged 3-18 y.The American journal of clinical nutrition, 76 6
P. Heine, Julia Taylor, G. Iwamoto, D. Lubahn, P. Cooke (2000)
Increased adipose tissue in male and female estrogen receptor-α knockout miceProceedings of the National Academy of Sciences of the United States of America, 97
S. Swan, K. Main, Fan Liu, S. Stewart, R. Kruse, A. Calafat, C. Mao, J. Redmon, C. Ternand, Shannon Sullivan, J. Teague (2005)
Decrease in Anogenital Distance among Male Infants with Prenatal Phthalate ExposureEnvironmental Health Perspectives, 113
L. Parks, J. Ostby, Christy Lambright, B. Abbott, G. Klinefelter, N. Barlow, L. Gray (2000)
The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat.Toxicological sciences : an official journal of the Society of Toxicology, 58 2
KL Howdeshell, AK Hotchkiss, KA Thayer, JG Vandenbergh, FS Saal (1999)
Exposure to bisphenol A advances pubertyNature, 401
N Sharifi, JL Gulley, WL Dahut (2005)
Androgen deprivation therapy for prostate cancerJama, 294
R. Newbold, E. Padilla‐Banks, Ryan Snyder, W. Jefferson (2005)
Developmental exposure to estrogenic compounds and obesity.Birth defects research. Part A, Clinical and molecular teratology, 73 7
S. Palin, P. McTernan, L. Anderson, D. Sturdee, A. Barnett, S. Kumar (2003)
17Beta-estradiol and anti-estrogen ICI:compound 182,780 regulate expression of lipoprotein lipase and hormone-sensitive lipase in isolated subcutaneous abdominal adipocytes.Metabolism: clinical and experimental, 52 4
Margaret Jones, A. Thorburn, K. Britt, K. Hewitt, N. Wreford, J. Proietto, Orhan Öz, B. Leury, K. Robertson, Shenggen Yao, E. Simpson (2000)
Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity.Proceedings of the National Academy of Sciences of the United States of America, 97 23
Hye-Kyeong Kim, C. Nelson-Dooley, M. Della-Fera, Jeong-Yeh Yang, Wei Zhang, J. Duan, D. Hartzell, M. Hamrick, C. Baile (2006)
Genistein decreases food intake, body weight, and fat pad weight and causes adipose tissue apoptosis in ovariectomized female mice.The Journal of nutrition, 136 2
N. Danilovich, P. Babu, Weirong Xing, Maria Gerdes, Hanumanthappa Krishnamurthy, And Sairam, Ram Sairam (2000)
Estrogen deficiency, obesity, and skeletal abnormalities in follicle-stimulating hormone receptor knockout (FORKO) female mice.Endocrinology, 141 11
C. Hurst, D. Waxman (2003)
Activation of PPARα and PPARγ by Environmental Phthalate MonoestersToxicological Sciences, 74
R. Pasquali, V. Vicennati, M. Cacciari, U. Pagotto (2006)
The Hypothalamic‐Pituitary‐Adrenal Axis Activity in Obesity and the Metabolic SyndromeAnnals of the New York Academy of Sciences, 1083
K. Howdeshell, A. Hotchkiss, K. Thayer, J. Vandenbergh, F. Saal (1999)
Environmental toxins: Exposure to bisphenol A advances pubertyNature, 401
H. Masuno, Shoko Okamoto, J. Iwanami, K. Honda, T. Shiosaka, T. Kidani, K. Sakayama, Haruyasu Yamamoto (2003)
Effect of 4-nonylphenol on cell proliferation and adipocyte formation in cultures of fully differentiated 3T3-L1 cells.Toxicological sciences : an official journal of the Society of Toxicology, 75 2
Stéphane Rocchi, Frédéric Picard, Joseph Vamecq, L. Gelman, N. Potier, Denis Zeyer, Laurent Dubuquoy, Pierre Bac, M. Champy, K. Plunket, L. Leesnitzer, Steven Blanchard, P. Desreumaux, Dino Moras, Jean-Paul Renaud, J. Auwerx (2001)
A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity.Molecular cell, 8 4
G. Wade, J. Gray, T. Bartness (1985)
Gonadal influences on adiposity.International journal of obesity, 9 Suppl 1
J. Haarbo, U. Marslew, A. Gotfredsen, C. Christiansen (1991)
Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause.Metabolism: clinical and experimental, 40 12
K. Appel (2004)
Organotin Compounds: Toxicokinetic AspectsDrug Metabolism Reviews, 36
Y. Shimasaki, T. Kitano, Y. Oshima, S. Inoue, N. Imada, T. Honjo (2003)
Tributyltin causes masculinization in fishEnvironmental Toxicology and Chemistry, 22
A. Chawla, J. Repa, R. Evans, D. Mangelsdorf (2001)
Nuclear receptors and lipid physiology: opening the X-files.Science, 294 5548
D. Kaufman, M. Banerji, Igor Shorman, Eric Smith, J. Coplan, L. Rosenblum, J. Kral (2007)
Early-Life Stress and the Development of Obesity and Insulin Resistance in Juvenile Bonnet MacaquesDiabetes, 56
Y. Mu, T. Yanase, Y. Nishi, R. Takayanagi, K. Goto, H. Nawata (2001)
Combined treatment with specific ligands for PPARγ:RXR nuclear receptor system markedly inhibits the expression of cytochrome P450arom in human granulosa cancer cellsMolecular and Cellular Endocrinology, 181
M. Ristow, D. Müller-Wieland, A. Pfeiffer, W. Krone, C. Kahn (1998)
Obesity associated with a mutation in a genetic regulator of adipocyte differentiation.The New England journal of medicine, 339 14
H. Imai, T. Nishimura, M. Sadamatsu, Y. Liu, M. Kabuto, N. Kato (2001)
Type II Glucocorticoid Receptors Are Involved in Neuronal Death and Astrocyte Activation Induced by Trimethyltin in the Rat HippocampusExperimental Neurology, 171
R. Lindsay, R. Lindsay, B. Waddell, J. Seckl (1996)
Prenatal glucocorticoid exposure leads to offspring hyperglycaemia in the rat: studies with the 11 b -hydroxysteroid dehydrogenase inhibitor carbenoxoloneDiabetologia, 39
A. Naaz, Srikanth Yellayi, M. Zakroczymski, D. Bunick, D. Doerge, D. Lubahn, W. Helferich, P. Cooke (2003)
The soy isoflavone genistein decreases adipose deposition in mice.Endocrinology, 144 8
B. McAllister, D. Kime (2003)
Early life exposure to environmental levels of the aromatase inhibitor tributyltin causes masculinisation and irreversible sperm damage in zebrafish (Danio rerio).Aquatic toxicology, 65 3
J. Neel (1962)
Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?American journal of human genetics, 14
J. Fisher (2004)
Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome.Reproduction, 127 3
H. Masuzaki, Hiroshi Yamamoto, C. Kenyon, J. Elmquist, N. Morton, J. Paterson, H. Shinyama, M. Sharp, S. Fleming, J. Mullins, J. Seckl, J. Flier (2003)
Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.The Journal of clinical investigation, 112 1
N. Butte, J. Hopkinson, W. Wong, E. Smith, K. Ellis (2000)
Body Composition during the First 2 Years of Life: An Updated ReferencePediatric Research, 47
E. Maloney, D. Waxman (1999)
trans-activation of PPARα and PPARγ by structurally diverse environmental chemicalsToxicology and Applied Pharmacology, 161
S. Blaber (1970)
THE OCCURRENCE OF A PENIS-LIKE OUTGROWTH BEHIND THE RIGHT TENTACLE IN SPENT FEMALES OF NUCELLA LAPILLUS (L.)Journal of Molluscan Studies, 39
R. Nilsson (2000)
Endocrine Modulators in the Food Chain and EnvironmentToxicologic Pathology, 28
Laura Julan, H. Guan, J. Beek, Kaiping Yang (2005)
Peroxisome Proliferator-Activated Receptor δ Suppresses 11β-Hydroxysteroid Dehydrogenase Type 2 Gene Expression in Human Placental Trophoblast CellsEndocrinology, 146
A. Atanasov, Steven Tam, Jens Röcken, M. Baker, A. Odermatt (2003)
Inhibition of 11β-hydroxysteroid dehydrogenase type 2 by dithiocarbamatesBiochemical and Biophysical Research Communications, 308
S. Gesta, M. Blüher, Yuji Yamamoto, A. Norris, J. Berndt, S. Kralisch, J. Boucher, C. Lewis, C. Kahn (2006)
Evidence for a role of developmental genes in the origin of obesity and body fat distribution.Proceedings of the National Academy of Sciences of the United States of America, 103 17
本間 裕朗 (2000)
Estrogen Suppresses Transcription of Lipoprotein Lipase Gene : Existence of a unique estrogen response element on the lipoprotein lipase promoter
David Barker (1993)
Fetal origins of coronary heart disease.British Heart Journal, 69
D. Goodman-gruen, D. Kritz-Silverstein (2003)
Usual dietary isoflavone intake and body composition in postmenopausal womenMenopause, 10
A. Atanasov, Steven Tam, Jens Röcken, M. Baker, A. Odermatt (2003)
Inhibition of 11 beta-hydroxysteroid dehydrogenase type 2 by dithiocarbamates.Biochemical and biophysical research communications, 308 2
J. Seckl (1997)
Glucocorticoids, feto-placental 11β-hydroxysteroid dehydrogenase type 2, and the early life origins of adult diseaseSteroids, 62
MK Mohamed, A. Abdel‐Rahman (2000)
Effect of long-term ovariectomy and estrogen replacement on the expression of estrogen receptor gene in female rats.European journal of endocrinology, 142 3
T. Stulnig, U. Oppermann, K. Steffensen, Gertrud Schuster, J. Gustafsson (2002)
Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.Diabetes, 51 8
P. Björntorp (1996)
The regulation of adipose tissue distribution in humans.International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 20 4
Jian Wu, J. Oka, I. Tabata, M. Higuchi, T. Toda, N. Fuku, J. Ezaki, Fumie Sugiyama, Shigeto Uchiyama, Kazuhiko Yamada, Y. Ishimi (2006)
Effects of Isoflavone and Exercise on BMD and Fat Mass in Postmenopausal Japanese Women: A 1‐Year Randomized Placebo‐Controlled TrialJournal of Bone and Mineral Research, 21
A. Rubenstrunk, Rémy Hanf, D. Hum, J. Fruchart, B. Staels (2007)
Safety issues and prospects for future generations of PPAR modulators.Biochimica et biophysica acta, 1771 8
D. Heidrich, S. Steckelbroeck, D. Klingmuller (2001)
Inhibition of human cytochrome P450 aromatase activity by butyltinsSteroids, 66
P. Björntorp, R. Rosmond (2000)
Obesity and cortisol.Nutrition, 16 10
SA Jebb (2002)
Eating disorder and obesity
Y. Mu, T. Yanase, Y. Nishi, N. Waseda, Tanaka Oda, Atsushi Tanaka, R. Takayanagi, H. Nawata (2000)
Insulin sensitizer, troglitazone, directly inhibits aromatase activity in human ovarian granulosa cells.Biochemical and biophysical research communications, 271 3
A. Atanasov, Lyubomir Nashev, Steven Tam, M. Baker, A. Odermatt (2005)
Organotins Disrupt the 11β-Hydroxysteroid Dehydrogenase Type 2–Dependent Local Inactivation of GlucocorticoidsEnvironmental Health Perspectives, 113
H. Masuno, J. Iwanami, T. Kidani, K. Sakayama, K. Honda (2005)
Bisphenol a accelerates terminal differentiation of 3T3-L1 cells into adipocytes through the phosphatidylinositol 3-kinase pathway.Toxicological sciences : an official journal of the Society of Toxicology, 84 2
R. Stahlhut, E. Wijngaarden, T. Dye, S. Cook, S. Swan (2007)
Concentrations of Urinary Phthalate Metabolites Are Associated with Increased Waist Circumference and Insulin Resistance in Adult U.S. MalesEnvironmental Health Perspectives, 115
M. Nyirenda, R. Lindsay, C. Kenyon, A. Burchell, J. Seckl (1998)
Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring.The Journal of clinical investigation, 101 10
J. Tomlinson, J. Moore, M. Cooper, I. Bujalska, M. Shahmanesh, C. Burt, A. Strain, M. Hewison, P. Stewart (2001)
Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.Endocrinology, 142 5
E. Cerasi, P. Dieterle, H. Ege, A. Englhardt, H. Frerichs, W. Gepts, A. Hasselblatt, H. Henrichs, L. Herberg, J. Hoet, H. Hungerland, K. Jahnke, R. Jarrett, G. Jörgensen, K. Jørgensen, H. Kasemir, H. Keen, L. Kerp, V. Leclercq-Meyer, H. Liebermeister, G. Löffler, R. Luft, Willy Malaisse, J. Markussen, M. Möllering, H. Schadewaldt, J. Schlichtkrull, K. Schöffling, U. Schwedes, Peter Scriba, F. Sundby, Klaus-Henning Usadel, L. Weiss, H. Zimmermann, K. Oberdisse (1924)
DIABETES MELLITUSMedical Journal of Australia, 1
A. Hermanowski‐Vosatka, D. Gerhold, S. Mundt, V. Loving, M. Lu, Y. Chen, A. Elbrecht, M. Wu, T. Doebber, L. Kelly, D. Milot, Q. Guo, P. Wang, M. Ippolito, Y. Chao, S. Wright, R. Thieringer (2000)
PPARalpha agonists reduce 11beta-hydroxysteroid dehydrogenase type 1 in the liver.Biochemical and biophysical research communications, 279 2
C. Handschin, U. Meyer (2005)
Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.Archives of biochemistry and biophysics, 433 2
A. Hermanowski‐Vosatka, D. Gerhold, S. Mundt, V. Loving, Meiqing Lu, Yuli Chen, A. Elbrecht, Margaret Wu, T. Doebber, L. Kelly, D. Milot, Q. Guo, Pei-ran Wang, M. Ippolito, Y. Chao, S. Wright, R. Thieringer (2000)
PPARα Agonists Reduce 11β-Hydroxysteroid Dehydrogenase Type 1 in the LiverBiochemical and Biophysical Research Communications, 279
T. Horiguchi (2006)
Masculinization of female gastropod mollusks induced by organotin compounds, focusing on mechanism of actions of tributyltin and triphenyltin for development of imposex.Environmental sciences : an international journal of environmental physiology and toxicology, 13 2
K. Sakurai, Michiru Kawazuma, T. Adachi, T. Harigaya, Y. Saito, N. Hashimoto, C. Mori (2004)
Bisphenol A affects glucose transport in mouse 3T3‐F442A adipocytesBritish Journal of Pharmacology, 141
E. Maloney, D. Waxman (1999)
trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals.Toxicology and applied pharmacology, 161 2
D. Crews, J. Mclachlan (2006)
Epigenetics, evolution, endocrine disruption, health, and disease.Endocrinology, 147 6 Suppl
R. Waring, R. Harris (2005)
Endocrine disrupters: A human risk?Molecular and Cellular Endocrinology, 244
J. Feige, L. Gelman, D. Rossi, V. Zoete, R. Métivier, Cicerone Tudor, S. Anghel, A. Grosdidier, Caroline Lathion, Y. Engelborghs, O. Michielin, W. Wahli, B. Desvergne (2007)
The Endocrine Disruptor Monoethyl-hexyl-phthalate Is a Selective Peroxisome Proliferator-activated Receptor γ Modulator That Promotes Adipogenesis*Journal of Biological Chemistry, 282
E. Oken, Susanna Huh, E. Taveras, J. Rich-Edwards, M. Gillman (2005)
Associations of maternal prenatal smoking with child adiposity and blood pressure.Obesity research, 13 11
S. Rangwala, M. Lazar (2003)
Transcriptional control of adipogenesis.Annual review of nutrition, 20
A. Odermatt, Christel Gumy, A. Atanasov, Anna Dzyakanchuk (2006)
Disruption of glucocorticoid action by environmental chemicals: Potential mechanisms and relevanceThe Journal of Steroid Biochemistry and Molecular Biology, 102
J. Auwerx (1999)
PPARgamma, the ultimate thrifty gene.Diabetologia, 42 9
K. Main, G. Mortensen, M. Kaleva, K. Boisen, I. Damgaard, M. Chellakooty, I. Schmidt, Anne-Maarit Suomi, H. Virtanen, J. Petersen, A. Andersson, J. Toppari, N. Skakkebæk (2005)
Human Breast Milk Contamination with Phthalates and Alterations of Endogenous Reproductive Hormones in Infants Three Months of AgeEnvironmental Health Perspectives, 114
Y. Kageyama, H. Suzuki, T. Saruta (1992)
Glycyrrhizin induces mineralocorticoid activity through alterations in cortisol metabolism in the human kidney.The Journal of endocrinology, 135 1
M. Heim, M. Heim, O. Frank, G. Kampmann, N. Sochocky, T. Pennimpede, P. Fuchs, W. Hunziker, P. Weber, I. Martin, I. Bendik (2004)
The phytoestrogen genistein enhances osteogenesis and represses adipogenic differentiation of human primary bone marrow stromal cells.Endocrinology, 145 2
B. Rubin, Mary Murray, D. Damassa, J. King, Ana Soto (2001)
Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels.Environmental Health Perspectives, 109
C. Shively, T. Clarkson (2009)
Regional obesity and coronary artery atherosclerosis in females: a non-human primate model.Acta medica Scandinavica. Supplementum, 723
(2002)
Energy intake and body weight. In: Fairburn CG, Brownwell KD, editors. Eating disorder and obesity
P. Matthiessen, P. Gibbs (1998)
Critical appraisal of the evidence for tributyltin‐mediated endocrine disruption in mollusksEnvironmental Toxicology and Chemistry, 17
C. Yen, B. Beamer, C. Negri, K. Silver, K. Brown, D. Yarnall, D. Burns, J. Roth, A. Shuldiner (1997)
Molecular Scanning of the Human Peroxisome Proliferator Activated Receptor γ (hPPARγ) Gene in Diabetic Caucasians: Identification of a Pro12Ala PPARγ2 Missense MutationBiochemical and Biophysical Research Communications, 241
I. Weaver, F. Champagne, Shelley Brown, Sergiy Dymov, Shakti Sharma, M. Meaney, M. Szyf (2005)
Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in LifeThe Journal of Neuroscience, 25
Elizabeth Cottrell, S. Ozanne (2007)
Developmental programming of energy balance and the metabolic syndromeProceedings of the Nutrition Society, 66
A. Mamun, D. Lawlor, R. Alati, M. O'callaghan, Gail Williams, J. Najman (2006)
Does maternal smoking during pregnancy have a direct effect on future offspring obesity? Evidence from a prospective birth cohort study.American journal of epidemiology, 164 4
C. Power, B. Jefferis (2002)
Fetal environment and subsequent obesity: a study of maternal smoking.International journal of epidemiology, 31 2
J. Mclachlan (2001)
Environmental signaling: what embryos and evolution teach us about endocrine disrupting chemicals.Endocrine reviews, 22 3
F. Bell (1982)
Effects of phthalate esters on lipid metabolism in various tissues, cells and organelles in mammals.Environmental Health Perspectives, 45
Laura Julan, H. Guan, J. Beek, Kaiping Yang (2005)
Peroxisome proliferator-activated receptor delta suppresses 11beta-hydroxysteroid dehydrogenase type 2 gene expression in human placental trophoblast cells.Endocrinology, 146 3
C. Yen, B. Beamer, C. Negri, K. Silver, K. Brown, D. Yarnall, D. Burns, J. Roth, A. Shuldiner (1997)
Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation.Biochemical and biophysical research communications, 241 2
SJM Blaber (1970)
The occurrence of a penis-like outgrowth behind the right tentacle in spent females of Nucella lapillusProc Malacol Soc Lond, 39
M. Penza, C. Montani, A. Romani, P. Vignolini, B. Pampaloni, A. Tanini, M. Brandi, P. Alonso-Magdalena, A. Nadal, L. Ottobrini, O. Parolini, E. Bignotti, S. Calza, A. Maggi, P. Grigolato, D. Lorenzo (2007)
Genistein affects adipose tissue deposition in a dose-dependent and gender-specific manner.Endocrinology, 147 12
R. Newbold (1995)
Cellular and molecular effects of developmental exposure to diethylstilbestrol: implications for other environmental estrogens.Environmental Health Perspectives, 103
Nicholas Hales, David Barker, C Hales (2001)
The thrifty phenotype hypothesis.British medical bulletin, 60
H. Inadera, Akiko Shimomura (2005)
Environmental chemical tributyltin augments adipocyte differentiation.Toxicology letters, 159 3
T. Larsen, S. Toubro, A. Astrup (2003)
PPARgamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy?International Journal of Obesity, 27
Y. Fukui, Seishi Masui, S. Osada, K. Umesono, K. Motojima (2000)
A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice.Diabetes, 49 5
S. Lo, A. Alléra, P. Albers, J. Heimbrecht, E. Jantzen, D. Klingmüller, S. Steckelbroeck (2003)
Dithioerythritol (DTE) prevents inhibitory effects of triphenyltin (TPT) on the key enzymes of the human sex steroid hormone metabolismThe Journal of Steroid Biochemistry and Molecular Biology, 84
Yoko Murata, K. Robertson, Margaret Jones, Evan Simpson (2002)
Effect of estrogen deficiency in the male: the ArKO mouse modelMolecular and Cellular Endocrinology, 193
M. Braga‐Basaria, A. Dobs, D. Muller, M. Carducci, M. John, J. Egan, S. Basaria (2006)
Metabolic syndrome in men with prostate cancer undergoing long-term androgen-deprivation therapy.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 24 24
I. Weaver, N. Cervoni, F. Champagne, A. D’Alessio, Shakti Sharma, J. Seckl, Sergiy Dymov, M. Szyf, M. Meaney (2004)
Epigenetic programming by maternal behaviorNature Neuroscience, 7
F. Grün, Hajime Watanabe, Zaman Zamanian, Lauren Maeda, K. Arima, Ryan Cubacha, D. Gardiner, J. Kanno, T. Iguchi, B. Blumberg (2006)
Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates.Molecular endocrinology, 20 9
Tomohiko Kanayama, Naoki Kobayashi, S. Mamiya, T. Nakanishi, J. Nishikawa (2005)
Organotin Compounds Promote Adipocyte Differentiation as Agonists of the Peroxisome Proliferator-Activated Receptor γ/Retinoid X Receptor PathwayMolecular Pharmacology, 67
R. Newbold, E. Padilla‐Banks, Ryan Snyder, T. Phillips, W. Jefferson (2007)
Developmental exposure to endocrine disruptors and the obesity epidemic.Reproductive toxicology, 23 3
I. Boyer (1989)
Toxicity of dibutyltin, tributyltin and other organotin compounds to humans and to experimental animals.Toxicology, 55 3
Z. Dang, V. Audinot, S. Papapoulos, J. Boutin, C. Löwik (2003)
Peroxisome proliferator-activated receptor gamma (PPARgamma ) as a molecular target for the soy phytoestrogen genistein.The Journal of biological chemistry, 278 2
E. Rosen, P. Sarraf, A. Troy, G. Bradwin, K. Moore, D. Milstone, B. Spiegelman, R. Mortensen (1999)
PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro.Molecular cell, 4 4
C. Yajnik (2000)
Interactions of perturbations in intrauterine growth and growth during childhood on the risk of adult-onset diseaseProceedings of the Nutrition Society, 59
E. Rosen, P. Sarraf, A. Troy, G. Bradwin, K. Moore, D. Milstone, B. Spiegelman, R. Mortensen (1999)
PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In VitroMolecular Cell, 4
C. Hurst, D. Waxman (2003)
Activation of PPARalpha and PPARgamma by environmental phthalate monoesters.Toxicological sciences : an official journal of the Society of Toxicology, 74 2
Paula Baillie-Hamilton (2002)
Chemical toxins: a hypothesis to explain the global obesity epidemic.Journal of alternative and complementary medicine, 8 2
J. Nishikawa, S. Mamiya, Tomohiko Kanayama, T. Nishikawa, F. Shiraishi, T. Horiguchi (2004)
Involvement of the retinoid X receptor in the development of imposex caused by organotins in gastropods.Environmental science & technology, 38 23
R Pasquali, V Vicennati, M Cacciari, U Pagotto (2006)
The hypothalamic–pituitary–adrenal axis activity in obesity and the metabolic syndromeAnn NY Acad Sci, 1083
JN Feige, L Gelman, D Rossi, V Zoete, R Metivier, C Tudor (2007)
The endocrine disruptor mono-ethyl-hexyl-phthalate is a selective PPARgamma modulator which promotes adipogenesisJ Biol Chem, 282
The modern world is plagued with expanding epidemics of diseases related to metabolic dysfunction. The factors that are driving obesity, diabetes, cardiovascular disease, hypertension, and dyslipidemias (collectively termed metabolic syndrome) are usually ascribed to a mismatch between the body’s homeostatic nutrient requirements and dietary excess, coupled with insufficient exercise. The environmental obesogen hypothesis proposes that exposure to a toxic chemical burden is superimposed on these conditions to initiate or exacerbate the development of obesity and its associated health consequences. Recent studies have proposed a first set of candidate obesogens (diethylstilbestrol, bisphenol A, phthalates and organotins among others) that target nuclear hormone receptor signaling pathways (sex steroid, RXR–PPARγ and GR) with relevance to adipocyte biology and the developmental origins of health and disease (DOHaD). Perturbed nuclear receptor signaling can alter adipocyte proliferation, differentiation or modulate systemic homeostatic controls, leading to long-term consequences that may be magnified if disruption occurs during sensitive periods during fetal or early childhood development.
Reviews in Endocrine and Metabolic Disorders – Springer Journals
Published: Jul 27, 2007
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.