Digestive Diseases and Sciences, Vol. 44, No. 8 (August 1999), pp. 1499 ± 1505 REVIEW ARTICLE Perspectives on Bi® dobacteria as Biotherapeutic Agents in Gastrointestinal Health LINDA C. DUFFY, PhD, ALLEN LEAVENS, MS, ELIZABETH GRIFFITHS, PhD, and DIANE DRYJA, MT(ASCP), CLS KEY WORDS: bacterial translocation; bi® dobacteria; probiotics; prebiotics. Intestinal micro¯ ora carry out a process of fermenta- Gram-positive anaerobes (lactobacilli; bi® dobacte - tion where dietary and endoge nous substrates are ria) stimulate d by feeding breast milk play a key role metabolize d within the intestinal tract of the host in preventing pathoge n colonization and transloca- animal they inhabit (1). Enteric infections may de- tion of bacteria into mesenteric lymph node s (MLNs) velop when the normal ¯ ora are disrupte d by antibi- after inge stion (12, 13). Alternatively, increased per- otics or medical procedures. Microorganism s mixed meability to bacteria at the mucosal level contribute s in fermented milk products and poultices have been to passage of enteropathoge ns associated with prema- used since antiquity to treat enteric and respiratory turity and enteric feeding. In addition, decreased infections (2). There is increasing interest in the cur- colonization resistance associated with increased rent literature in
Digestive Diseases and Sciences – Springer Journals
Published: Oct 8, 2004
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