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Pathogenicity and antifungal susceptibility of Chaetomium species

Pathogenicity and antifungal susceptibility of Chaetomium species Several reports have been published implicating Chaetomium spp. as opportunistic pathogens. A critical review of these cases was made, and the majority of the responsible strains were studied. Chaetomium globosum was the most common species, being isolated in at least nine clinical cases of infection. Some of these clinical isolates and others from environmental sources were tested against six antifungal agents (5-fluorocytosine, fluconazole, amphotericin B, itraconazole, ketoconazole and miconazole). The 23 strains tested were totally resistant to the first two drugs, and none of the other antifungal agents demonstrated fungicidal activity. There were no significant differences between the susceptibility of the clinical strains and the other strains. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Microbiology Infectious Diseases Springer Journals

Pathogenicity and antifungal susceptibility of Chaetomium species

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References (16)

Publisher
Springer Journals
Copyright
Copyright © 1995 by Springer-Verlag
Subject
Biomedicine; Medical Microbiology; Internal Medicine
ISSN
0934-9723
eISSN
1435-4373
DOI
10.1007/BF01690737
Publisher site
See Article on Publisher Site

Abstract

Several reports have been published implicating Chaetomium spp. as opportunistic pathogens. A critical review of these cases was made, and the majority of the responsible strains were studied. Chaetomium globosum was the most common species, being isolated in at least nine clinical cases of infection. Some of these clinical isolates and others from environmental sources were tested against six antifungal agents (5-fluorocytosine, fluconazole, amphotericin B, itraconazole, ketoconazole and miconazole). The 23 strains tested were totally resistant to the first two drugs, and none of the other antifungal agents demonstrated fungicidal activity. There were no significant differences between the susceptibility of the clinical strains and the other strains.

Journal

European Journal of Clinical Microbiology Infectious DiseasesSpringer Journals

Published: Jul 1, 1995

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