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Pathogenesis of postweaning multisystemic wasting syndrome caused by Porcine circovirus 2 : an immune riddle

Pathogenesis of postweaning multisystemic wasting syndrome caused by Porcine circovirus 2 : an... Postweaning multisystemic wasting syndrome (PMWS) is a disease of pigs first recognised in North America in 1997 and subsequently reported worldwide that is caused by Porcine circovirus 2 (PCV2), a member of the family Circoviridae . The most consistent feature of PMWS is a generalized depletion of lymphocytes. Secondary infections with opportunistic organisms are common. There is evidence that the destruction of thymic lymphocytes has a central role in the pathogenesis of PMWS. Pigs with PMWS have altered cytokine responses to mitogens and recall antigens. It remains unknown what cells are primarily infected and are permissive for the replication of PCV2. Macrophages and dendritic cells commonly contain virus in their cytoplasm but may not be the primary source of the large amounts of virus found in tissues of diseased pigs. There is evidence that PCV2, like mammalian parvoviruses, requires cells in the S phase of the cell cycle for replication. It has been difficult to reproduce PMWS experimentally although some protocols have been developed which involve antigenic stimulation with other agents that presumably increase the number of permissive cells entering S phase of the cell cycle. In addition to reviewing the literature attempts are made to identify key unresolved areas that should be the focus of future research. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Pathogenesis of postweaning multisystemic wasting syndrome caused by Porcine circovirus 2 : an immune riddle

Darwich, L.; Segalés, J.; Mateu, E.
Archives of Virology , Volume 149 (5) – May 1, 2004
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References (84)

Publisher
Springer Journals
Copyright
Copyright © 2004 by Springer-Verlag/Wien
Subject
LifeSciences
ISSN
0304-8608
eISSN
1432-8798
DOI
10.1007/s00705-003-0280-9
pmid
15098103
Publisher site
See Article on Publisher Site

Abstract

Postweaning multisystemic wasting syndrome (PMWS) is a disease of pigs first recognised in North America in 1997 and subsequently reported worldwide that is caused by Porcine circovirus 2 (PCV2), a member of the family Circoviridae . The most consistent feature of PMWS is a generalized depletion of lymphocytes. Secondary infections with opportunistic organisms are common. There is evidence that the destruction of thymic lymphocytes has a central role in the pathogenesis of PMWS. Pigs with PMWS have altered cytokine responses to mitogens and recall antigens. It remains unknown what cells are primarily infected and are permissive for the replication of PCV2. Macrophages and dendritic cells commonly contain virus in their cytoplasm but may not be the primary source of the large amounts of virus found in tissues of diseased pigs. There is evidence that PCV2, like mammalian parvoviruses, requires cells in the S phase of the cell cycle for replication. It has been difficult to reproduce PMWS experimentally although some protocols have been developed which involve antigenic stimulation with other agents that presumably increase the number of permissive cells entering S phase of the cell cycle. In addition to reviewing the literature attempts are made to identify key unresolved areas that should be the focus of future research.

Journal

Archives of Virology – Springer Journals

Published: May 1, 2004

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