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Papaverine

Papaverine Reactions 1680, p272 - 2 Dec 2017 Bilateral mydriasis and symptomatic, angiographic bilateral middle cerebral artery (MCA) vasospasm with end branch stroke in right MCA: case report A 55-year-old woman developed bilateral mydriasis and symptomatic, angiographic bilateral middle cerebral artery (MCA) vasospasm with end branch stroke in right MCA following papaverine toxicity. The woman with a history of rheumatoid arthritis was hospitalised for sudden onset of severe headache. A CT scan showed Hunt and Hess and modified Fisher along with aneurysms at the junction of left AI A2 and anterior communicating artery, left MCA, and right MCA. Subsequently, she underwent a left-sided craniotomy with lumbar drain placement for intraoperative cerebrospinal fluid diversion. Her left MCA was clipped and she was administered 3% intracisternal papaverine 60 mg/2mL over the manipulated vessels of the left anterior cerebral artery, MCA, and internal carotid artery in the oculomotor and suprachiasmatic cisterns as well as the Sylvian fissure. Following emergence from anaesthesia, her light reflex was absent bilaterally. Pilocarpine test showed no pupillary response. Following the neuro- ophthalmologic examination, an intracisternal mediated bilateral mydriasis was identified. Her mydriasis resolved after 23 days. However, her clinical course was complicated by occurrence of symptomatic and angiographic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Papaverine

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017

Papaverine

Abstract

Reactions 1680, p272 - 2 Dec 2017 Bilateral mydriasis and symptomatic, angiographic bilateral middle cerebral artery (MCA) vasospasm with end branch stroke in right MCA: case report A 55-year-old woman developed bilateral mydriasis and symptomatic, angiographic bilateral middle cerebral artery (MCA) vasospasm with end branch stroke in right MCA following papaverine toxicity. The woman with a history of rheumatoid arthritis was hospitalised for sudden onset of severe headache. A CT scan showed...
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References (1)

Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-017-39203-7
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p272 - 2 Dec 2017 Bilateral mydriasis and symptomatic, angiographic bilateral middle cerebral artery (MCA) vasospasm with end branch stroke in right MCA: case report A 55-year-old woman developed bilateral mydriasis and symptomatic, angiographic bilateral middle cerebral artery (MCA) vasospasm with end branch stroke in right MCA following papaverine toxicity. The woman with a history of rheumatoid arthritis was hospitalised for sudden onset of severe headache. A CT scan showed Hunt and Hess and modified Fisher along with aneurysms at the junction of left AI A2 and anterior communicating artery, left MCA, and right MCA. Subsequently, she underwent a left-sided craniotomy with lumbar drain placement for intraoperative cerebrospinal fluid diversion. Her left MCA was clipped and she was administered 3% intracisternal papaverine 60 mg/2mL over the manipulated vessels of the left anterior cerebral artery, MCA, and internal carotid artery in the oculomotor and suprachiasmatic cisterns as well as the Sylvian fissure. Following emergence from anaesthesia, her light reflex was absent bilaterally. Pilocarpine test showed no pupillary response. Following the neuro- ophthalmologic examination, an intracisternal mediated bilateral mydriasis was identified. Her mydriasis resolved after 23 days. However, her clinical course was complicated by occurrence of symptomatic and angiographic

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

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