Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/p2x-purinoceptors-and-sensory-transmission-0npxT9zoeo
References (87)
-
R. Dubner, G. Bennett (1983)
Spinal and trigeminal mechanisms of nociception.Annual review of neuroscience, 6
-
B. Lynn (1990)
Capsaicin: actions on nociceptive C-fibres and therapeutic potentialPain, 41
-
H. Ikeda, B. Heinke, R. Ruscheweyh, J. Sandkühler (2003)
Synaptic Plasticity in Spinal Lamina I Projection Neurons That Mediate HyperalgesiaScience, 299
-
Craig Jahr, T. Jessell (1983)
ATP excites a subpopulation of rat dorsal horn neuronesNature, 304
-
T. Nakatsuka, J. Gu (2001)
ATP P2X Receptor-Mediated Enhancement of Glutamate Release and Evoked EPSCs in Dorsal Horn Neurons of the Rat Spinal CordThe Journal of Neuroscience, 21
-
S. Hugel, R. Schlichter (2000)
Presynaptic P2X Receptors Facilitate Inhibitory GABAergic Transmission between Cultured Rat Spinal Cord Dorsal Horn NeuronsThe Journal of Neuroscience, 20
-
S. Cook, E. McCleskey (2002)
Cell damage excites nociceptors through release of cytosolic ATPPain, 95
-
K. Tsuzuki, A. Ase, P. Séguéla, T. Nakatsuka, Cong-Yi Wang, J. She, J. Gu (2003)
TNP-ATP-resistant P2X ionic current on the central terminals and somata of rat primary sensory neurons.Journal of neurophysiology, 89 6
-
S. Hamilton, J. Warburton, A. Bhattacharjee, J. Ward, S. McMahon (2000)
ATP in human skin elicits a dose-related pain response which is potentiated under conditions of hyperalgesia.Brain : a journal of neurology, 123 ( Pt 6)
-
John Wood (2004)
Recent advances in understanding molecular mechanisms of primary afferent activationGut, 53
-
S. Ueno, M. Tsuda, T. Iwanaga, Kazuhide Inoue (1999)
Cell type‐specific ATP‐activated responses in rat dorsal root ganglion neuronsBritish Journal of Pharmacology, 126
-
A. Guo, L. Vulchanova, Jing Wang, X. Li, R. Elde (1999)
Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sitesEuropean Journal of Neuroscience, 11
-
L. Vulchanova, M. Riedl, S. Shuster, L. Stone, K. Hargreaves, G. Buell, A. Surprenant, R. North, R. Elde (1998)
P2X3 is expressed by DRG neurons that terminate in inner lamina IIEuropean Journal of Neuroscience, 10
-
J. Marvizón, V. Martínez, E. Grady, N. Bunnett, E. Mayer (1997)
Neurokinin 1 Receptor Internalization in Spinal Cord Slices Induced by Dorsal Root Stimulation Is Mediated by NMDA ReceptorsThe Journal of Neuroscience, 17
-
G. Burnstock (1977)
Autonomic neuroeffector junctions--reflex vasodilatation of the skin.The Journal of investigative dermatology, 69 1
-
V. Souslova, P. Cesare, Yanning Ding, A. Akopian, Louise Stanfa, R. Suzuki, K. Carpenter, A. Dickenson, S. Boyce, R. Hill, D. Nebenius-Oosthuizen, Andrew Smith, E. Kidd, J. Wood (2000)
Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X 3 receptorsNature, 407
-
M. Caterina, Tobias Rosen, M. Tominaga, A. Brake, D. Julius (1999)
A capsaicin-receptor homologue with a high threshold for noxious heatNature, 398
-
Y. Jo, R. Schlichter (1999)
Synaptic corelease of ATP and GABA in cultured spinal neuronsNature Neuroscience, 2
-
Chaoying Li, R. Peoples, T. Lanthorn, Zhi-wang Li, F. Weight (1999)
Distinct ATP-activated currents in different types of neurons dissociated from rat dorsal root ganglionNeuroscience Letters, 263
-
V. Ralevic, G. Burnstock (1998)
Receptors for purines and pyrimidines.Pharmacological reviews, 50 3
-
T. Nakatsuka, N. Mena, J. Ling, J. Gu (2001)
Depletion of substance P from rat primary sensory neurons by ATP, an implication of P2X receptor-mediated release of substance PNeuroscience, 107
-
K. Tsuzuki, E. Kondo, T. Fukuoka, Dai Yi, H. Tsujino, M. Sakagami, K. Noguchi (2001)
Differential regulation of P2X3 mRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory gangliaPain, 91
-
Z. Gerevich, P. Illés (2004)
P2Y receptors and pain transmissionPurinergic Signalling, 1
-
M. Tominaga, M. Caterina, A. Malmberg, Tobias Rosen, Heather Gilbert, K. Skinner, B. Raumann, A. Basbaum, D. Julius (1998)
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing StimuliNeuron, 21
-
J. Gu, M. Heft (2004)
P2X receptor-mediated purinergic sensory pathways to the spinal cord dorsal hornPurinergic Signalling, 1
-
M. Ramer, E. Bradbury, S. McMahon (2001)
Nerve growth factor induces P2X3 expression in sensory neuronsJournal of Neurochemistry, 77
-
G. Burnstock (1996)
A unifying purinergic hypothesis for the initiation of painThe Lancet, 347
-
I. Chessell, J. Hatcher, C. Bountra, A. Michel, J. Hughes, P. Green, J. Egerton, Melanie Murfin, J. Richardson, Wendy Peck, C. Grahames, M. Casula, Y. Yiangou, R. Birch, P. Anand, G. Buell (2005)
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic painPain, 114
-
G. Burnstock (2006)
Purinergic P2 receptors as targets for novel analgesics.Pharmacology & therapeutics, 110 3
-
S. Hamilton, A. Wade, S. McMahon (1999)
The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the ratBritish Journal of Pharmacology, 126
-
P. Bodin, G. Burnstock (1998)
Increased release of ATP from endothelial cells during acute inflammationInflammation Research, 47
-
M. Yoshimura, T. Jessell (1990)
Amino acid‐mediated EPSPs at primary afferent synapses with substantia gelatinosa neurones in the rat spinal cord.The Journal of Physiology, 430
-
A. Coutts, J. Jorizzo, R. Eady, M. Greaves, G. Burnstock (1981)
Adenosine triphosphate-evoked vascular changes in human skin: mechanism of action.European journal of pharmacology, 76 4
-
L. Vulchanova, Ulf Arvidsson, M. Riedl, J. Wang, G. Buell, A. Surprenant, R. North, Robert Elde (1996)
Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry.Proceedings of the National Academy of Sciences of the United States of America, 93 15
-
S. Hamilton, Stephen McMahon, G. Lewin (2001)
Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skinThe Journal of Physiology, 534
-
B. Rexed (1952)
The cytoarchitectonic organization of the spinal cord in the catJournal of Comparative Neurology, 96
-
RA North, EA Barnard (1997)
Nucleotide receptorsCurr Opin Neurobiol, 7
-
J. Gu (2003)
P2X Receptor-Mediated Modulation of Sensory Transmission to the Spinal Cord Dorsal HornThe Neuroscientist, 9
-
P. Honore, K. Kage, J. Mikusa, A. Watt, J. Johnston, J. Wyatt, C. Faltynek, M. Jarvis, K. Lynch (2002)
Analgesic profile of intrathecal P2X3 antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in ratsPAIN, 99
-
Kimiko Kobayashi, T. Fukuoka, H. Yamanaka, Yi Dai, K. Obata, A. Tokunaga, K. Noguchi (2005)
Differential expression patterns of mRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the ratJournal of Comparative Neurology, 481
-
S. Jeftinija (1988)
Enkephalins modulate excitatory synaptic transmission in the superficial dorsal horn by acting at μ-opioid receptor sitesBrain Research, 460
-
J. Petruska, N. Mena, T. Nakatsuka, B. Cooper, R. Johnson, J. Gu (2000)
P2X1 receptor subunit immunoreactivity and ATP‐evoked fast currents in adult rat dorsal root ganglion neuronsNeuroReport, 11
-
F. Edwards, A. Gibb, D. Colquhoun (1992)
ATP receptor-mediated synaptic currents in the central nervous systemNature, 359
-
G. Burnstock, Michael Williams (2000)
P2 purinergic receptors: modulation of cell function and therapeutic potential.The Journal of pharmacology and experimental therapeutics, 295 3
-
E. Burgard, W. Niforatos, T. Biesen, K. Lynch, E. Touma, R. Metzger, E. Kowaluk, M. Jarvis (1999)
P2X receptor-mediated ionic currents in dorsal root ganglion neurons.Journal of neurophysiology, 82 3
-
M. Tsuda, S. Ueno, Kazuhide Inoue (1999)
Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in miceBritish Journal of Pharmacology, 128
-
Z. Xiang, X. Bo, G. Burnstock (1998)
Localization of ATP-gated P2X receptor immunoreactivity in rat sensory and sympathetic gangliaNeuroscience Letters, 256
-
B. Khakh, G. Burnstock, C. Kennedy, B. King, R. North, P. Séguéla, M. Voigt, P. Humphrey (2001)
International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.Pharmacological reviews, 53 1
-
Hantao Liu, P. Mantyh, A. Basbaum (1997)
NMDA-receptor regulation of substance P release from primary afferent nociceptorsNature, 386
-
M. Tsuda, Yukari Shigemoto-mogami, S. Koizumi, Akito Mizokoshi, S. Kohsaka, M. Salter, Kazuhide Inoue (2003)
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injuryNature, 424
-
K. Kage, W. Niforatos, Chang Zhu, K. Lynch, P. Honore, M. Jarvis (2002)
Alteration of dorsal root ganglion P2X3 receptor expression and function following spinal nerve ligation in the ratExperimental Brain Research, 147
-
J. Rhee, Zhi Wang, J. Nabekura, Kazuhide Inoue, N. Akaike (2000)
ATP facilitates spontaneous glycinergic IPSC frequency at dissociated rat dorsal horn interneuron synapsesThe Journal of Physiology, 524
-
F. Holton, P. Holton (1953)
The possibility that ATP is a transmitter at sensory nerve endings.The Journal of physiology, 119 4
-
R. North, A. Surprenant (2000)
Pharmacology of cloned P2X receptors.Annual review of pharmacology and toxicology, 40
-
R. Bardoni, P. Goldstein, C. Lee, J. Gu, A. MacDermott (1997)
ATP P2X Receptors Mediate Fast Synaptic Transmission in the Dorsal Horn of the Rat Spinal CordThe Journal of Neuroscience, 17
-
T. Bleehen, C. Keele (1977)
Observations on the algogenic actions of adenosine compounds on the human blister base preparationPain, 3
-
C. Lewis, S. Neidhart, C. Holy, R. North, G. Buell, A. Surprenant (1995)
Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neuronsNature, 377
-
R. North (2002)
Molecular physiology of P2X receptors.Physiological reviews, 82 4
-
T. Nakatsuka, K. Tsuzuki, J. Ling, H. Sonobe, J. Gu (2003)
Distinct roles of P2X receptors in modulating glutamate release at different primary sensory synapses in rat spinal cord.Journal of neurophysiology, 89 6
-
C. Labrakakis, C. Tong, T. Weissman, C. Torsney, A. MacDermott (2003)
Localization and function of ATP and GABAA receptors expressed by nociceptors and other postnatal sensory neurons in ratThe Journal of Physiology, 549
-
W. Willis, R. Coggeshall (1979)
Sensory Mechanisms of the Spinal Cord -
T. Kohno, T. Kohno, E. Kumamoto, H. Higashi, K. Shimoji, M. Yoshimura (1999)
Actions of opioids on excitatory and inhibitory transmission in substantia gelatinosa of adult rat spinal cordThe Journal of Physiology, 518
-
A. MacDermott, L. Role, S. Siegelbaum (1999)
Presynaptic ionotropic receptors and the control of transmitter release.Annual review of neuroscience, 22
-
J. Li, E. Perl (1995)
ATP modulation of synaptic transmission in the spinal substantia gelatinosa, 15
-
O. Krishtal, S. Marchenko, V. Pidoplichko (1983)
Receptor for ATP in the membrane of mammalian sensory neuronesNeuroscience Letters, 35
-
Jun-Li Zhou, K. Chung, J. Chung (2001)
Development of purinergic sensitivity in sensory neurons after peripheral nerve injury in the ratBrain Research, 915
-
M. Tsuda, S. Koizumi, Aya Kita, Yukari Shigemoto, S. Ueno, Kazuhide Inoue (2000)
Mechanical Allodynia Caused by Intraplantar Injection of P2X Receptor Agonist in Rats: Involvement of Heteromeric P2X2/3 Receptor Signaling in Capsaicin-Insensitive Primary Afferent NeuronsThe Journal of Neuroscience, 20
-
Chih-Cheng Chen, A. Akopian, Lucia Sivilottit, D. Colquhoun, G. Burnstock, J. Wood (1995)
A P2X purinoceptor expressed by a subset of sensory neuronsNature, 377
-
E. Bradbury, G. Burnstock, S. McMahon (1998)
The Expression of P2X3Purinoreceptors in Sensory Neurons: Effects of Axotomy and Glial-Derived Neurotrophic FactorMolecular and Cellular Neuroscience, 12
-
D. Cockayne, S. Hamilton, Quan-Ming Zhu, P. Dunn, Y. Zhong, S. Novaković, A. Malmberg, G. Cain, A. Berson, L. Kassotakis, L. Hedley, W. Lachnit, G. Burnstock, S. McMahon, A. Ford (2000)
Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X 3-deficient miceNature, 407
-
Guang-yin Xu, L. Huang (2002)
Peripheral Inflammation Sensitizes P2X Receptor-Mediated Responses in Rat Dorsal Root Ganglion NeuronsThe Journal of Neuroscience, 22
-
S. Cook, L. Vulchanova, K. Hargreaves, R. Elde, E. McCleskey (1997)
Distinct ATP receptors on pain-sensing and stretch-sensing neuronsNature, 387
-
T. Nakatsuka, H. Furue, M. Yoshimura, J. Gu (2002)
Activation of Central Terminal Vanilloid Receptor-1 Receptors and αβ-Methylene-ATP-Sensitive P2X Receptors Reveals a Converged Synaptic Activity onto the Deep Dorsal Horn Neurons of the Spinal CordThe Journal of Neuroscience, 22
-
J. Petruska, B. Cooper, Richard Johnson, Jianguo Gu (2000)
Distribution patterns of different P2x receptor phenotypes in acutely dissociated dorsal root ganglion neurons of adult ratsExperimental Brain Research, 134
-
P. Bland-Ward, P. Humphrey (1997)
Acute nociception mediated by hindpaw P2X receptor activation in the ratBritish Journal of Pharmacology, 122
-
Kun Yang, E. Kumamoto, H. Furue, Yun-Qing Li, M. Yoshimura (1999)
Action of capsaicin on dorsal root-evoked synaptic transmission to substantia gelatinosa neurons in adult rat spinal cord slicesBrain Research, 830
-
W. Catterall, K. Chandy, D. Clapham, G. Gutman, Franz Hofmann, A. Harmar, D. Abernethy, M. Spedding (2003)
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion ChannelsPharmacological Reviews, 55
-
J. Sawynok, A. Reid (1997)
Peripheral adenosine 5'-triphosphate enhances nociception in the formalin test via activation of a purinergic p2X receptor.European journal of pharmacology, 330 2-3
-
J. Gu, A. MacDermott (1997)
Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapsesNature, 389
-
F. Cervero (1995)
What is a nociceptor-specific (class 3) cell?Pain, 62
-
S. McGaraughty, C. Wismer, Chang Zhu, J. Mikusa, P. Honore, K. Chu, Chih-Hung Lee, C. Faltynek, M. Jarvis (2003)
Effects of A‐317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administrationBritish Journal of Pharmacology, 140
-
G. Collo, R. North, E. Kawashima, E. Merlo-Pich, S. Neidhart, A. Surprenant, G. Buell (1996)
Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels, 16
-
Meng Chen, J. Gu (2005)
A P2X receptor-mediated nociceptive afferent pathway to lamina I of the spinal cordMolecular Pain, 1
-
Martin Paukert, R. Osteroth, Hyun-Soon Geisler, U. Brändle, E. Glowatzki, J. Ruppersberg, S. Gründer (2001)
Inflammatory Mediators Potentiate ATP-gated Channels through the P2X3 Subunit*The Journal of Biological Chemistry, 276
-
BY Hori, K. Endo, Tomoyuki TAKAHASHIt (1992)
Presynaptic inhibitory action of enkephalin on excitatory transmission in superficial dorsal horn of rat spinal cord.The Journal of Physiology, 450
-
G. Gmelin, M. Zimmermann (1983)
Effects of γ-aminobutyrate and bicuculline on primary afferent depolarization of cutaneous fibres in the cat spinal cordNeuroscience, 10
-
A. Brake, M. Wagenbach, D. Julius (1994)
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptorNature, 371
- Publisher
- Springer Journals
- Copyright
- Copyright © 2006 by Springer-Verlag
- Subject
- Biomedicine; Human Physiology
- ISSN
- 0031-6768
- eISSN
- 1432-2013
- DOI
- 10.1007/s00424-006-0057-6
- pmid
- 16547751
- Publisher site
- See Article on Publisher Site
Abstract
The involvement of P2X purinoreceptors (P2X receptors) in somatosensory transmission is herein reviewed with a focus on those receptors that are expressed on sensory neurons to elucidate their roles in the initiation of sensory excitation from primary afferent neurons, in modulating synaptic transmission at the first sensory synapses formed between primary afferent central terminals and dorsal horn neurons, in directly mediating sensory synaptic transmission to the spinal cord dorsal horn, and in modulating synaptic transmission among spinal cord dorsal horn neurons. Research on P2X receptors has indicated that these receptors play a significant role in both physiological and pathological pain states. As a result, P2X receptors may serve as therapeutic targets for the treatment of pathological pain conditions associated with nerve injury, tissue inflammation, cancer, and other diseases.
Journal
Pflügers Archiv European Journal of Physiologyl of Physiology – Springer Journals
Published: Mar 18, 2006