Psychopharmacology (2002) 162:448–450 DOI 10.1007/s00213-002-1158-3 LETTER TO T H E E DITORS A. Richard Green · Iain S. McGregor On the anxiogenic and anxiolytic nature of long-term cerebral 5-HT depletion following MDMA Received: 21 May 2002 / Accepted: 25 May 2002 / Published online: 27 June 2002 Springer-Verlag 2002 The role of 5-hydroxytryptamine (5-HT) in anxiety-like degree of 5-HT depletion (50–75%), but no effect when behaviour in rats has been studied for over 30 years but depletion was more severe (90%) (Hall et al. 1999). The still remains contentious. While a widely accepted view latter result contrasts with that of Briley et al. (1990), who has been that a reduction in 5-HT can lead to an anxiolytic observed clear anxiolytic effects following a similar effect in rats (Iversen 1984), perusal of the comprehensive severe neurotoxic loss of 5-HT. A tryptophan depletion reviews of Griebel (1995) and Soubrie (1986) rapidly study in rats, involving a procedure designed to produce a reveals that such a statement is now unsupportable: ample rapid and moderate decrease in cerebral 5-HT concentra- data are also available to support the hypothesis that tion and function, observed the rapid appearance of an lowering 5-HT function is anxiogenic.
Psychopharmacology – Springer Journals
Published: Aug 1, 2002
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