Diabetologia (1999) 42: 387±405 Ó Springer-Verlag 1999 Review Ocular blood flow and associated functional deviations in diabetic retinopathy 1, 2 1 L. Schmetterer , M. Wolzt Department of Clinical Pharmacology, University of Vienna Institute of Medical Physics, University of Vienna Keywords Diabetic retinopathy, ocular blood flow, abetes mellitus as well as in animal models of diabe- retinal blood flow, choroidal blood flow, pathogene- tes has attracted considerable research interest. sis, hyperglycaemia, endothelial dysfunction, ocular Much less attention has been paid to the choroidal blood flow techniques, validity, reproducibility. circulation in diabetes, which is surprising as much of the retinal oxygen is supplied from this vascular bed. In part this may arise from the difficulties in as- Diabetic retinopathy is among the leading causes of sessing choroidal blood flow in humans. A role for blindness in the industrialised nations. The clinical the choroidal circulation in the pathogenesis of dia- course of diabetic retinopathy has been described in betic retinopathy has been proposed previously, detail  and a grading system for the disease has based on histological studies of the diabetic choroid been elaborated [2, 3]. The mechanisms underlying [4±6]. Excessive basement membrane thickening in this severe complication of Type I
Diabetologia – Springer Journals
Published: Mar 1, 1999
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