Purpose of the Review Activation of myocardial cannabinoid type 1 receptors (CB1-R) and/or angiotensin II type 1 receptors (AT1-R) likely plays an important mechanistic role in determining the left-ventricular remodeling process in systolic heart failure. We provide an overview on novel radiotracer probes and positron emission tomography (PET)/computed tomography (CT) imaging to noninvasively probe the expression of myocardial CB1-R and/or AT1-R. 11 11 Recent Findings Recent translational investigations have demonstrated the feasibility of C-OMAR or C-KR31173 and PET/ CT to image and quantify myocardial CB1-R and/or AT1-R expression, respectively. There is an increasing understanding of the mechanisms of activated myocardial CB1-R and/or AT1-R to influence the left-ventricular remodeling process in systolic heart failure in different disease entities. Summary The review summarizes contributions of PET to image myocardial CB1-R and AT1-R expression that may have the potential to serve as a target to tailor preventive medical care in the individual patient. . . . . Keywords Angiotensin II type 1 receptors Angiotensin-converting enzyme Cannabinoid type 1 receptor Heart failure . . Left-ventricular remodeling Obesity Positron emission tomography Introduction The continuous steady increase in the prevalence of obesity in industrialized nations has reached a level as high as ∼ 30%. This
Current Cardiology Reports – Springer Journals
Published: May 18, 2019
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