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Novel liposomal forms of antifungal antibiotics modified by amphiphilic polymers

Novel liposomal forms of antifungal antibiotics modified by amphiphilic polymers A novel method was developed to incorporate macrocyclic polyene antibiotics, nystatin and amphotericin B, into liposomes prepared from the mixture of phosphatidylcholine and cholesterol (7: 3) or phosphatidylcholine, cholesterol, and cardiolipin (7: 3: 1). Membranes of the liposomes were modified using the amphiphilic polymer N-vinylpyrrolidone with the molecular mass (MM) of the polymer fragment of 4000 and a single terminal n-octadecyl group. The content of the antibiotic incorporated within such nanosize liposomal carriers can reach 17–22%. The obtained modified liposomes, 150–200 nm in size, were more stable during prolonged storage and more resistant to various destructive factors, such as destabilizing agents (Triton X-100, ethanol) and ultrasound. The liposomal preparations showed higher antifungal activity than non-immobilized antifungal antibiotics. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Biochemistry and Microbiology Springer Journals

Novel liposomal forms of antifungal antibiotics modified by amphiphilic polymers

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References (11)

Publisher
Springer Journals
Copyright
Copyright © 2008 by MAIK Nauka
Subject
Life Sciences; Medical Microbiology ; Microbiology ; Biochemistry, general
ISSN
0003-6838
eISSN
1608-3024
DOI
10.1134/S0003683808060112
Publisher site
See Article on Publisher Site

Abstract

A novel method was developed to incorporate macrocyclic polyene antibiotics, nystatin and amphotericin B, into liposomes prepared from the mixture of phosphatidylcholine and cholesterol (7: 3) or phosphatidylcholine, cholesterol, and cardiolipin (7: 3: 1). Membranes of the liposomes were modified using the amphiphilic polymer N-vinylpyrrolidone with the molecular mass (MM) of the polymer fragment of 4000 and a single terminal n-octadecyl group. The content of the antibiotic incorporated within such nanosize liposomal carriers can reach 17–22%. The obtained modified liposomes, 150–200 nm in size, were more stable during prolonged storage and more resistant to various destructive factors, such as destabilizing agents (Triton X-100, ethanol) and ultrasound. The liposomal preparations showed higher antifungal activity than non-immobilized antifungal antibiotics.

Journal

Applied Biochemistry and MicrobiologySpringer Journals

Published: Oct 28, 2008

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