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Non-Aspergillus Fungal Infections in Chronic Granulomatous Disease

Non-Aspergillus Fungal Infections in Chronic Granulomatous Disease Purpose of Review Management of Aspergillus infection in chronic granulomatous disease (CGD) patients remains a challenge even in new azoles era. However, epidemiology, diagnosis, and management of non-Aspergillus fungal infection (NAFI) in CGD setting are poorly described. Recent Findings NAFI appears to be rare in CGD patients and receiving antifungal prophylaxis. Clinical presentation is not specific of fungal species and patients often suffer from mild disease with prolonged course. While candidiasis and mucormycosis are also common in other immunocompromised population, infections caused by Phellinus tropicalis, Trichosporon inkin,and Rasamsonia argillacea have a unique predilection for CGD patients. Improved fungal identification with molecular methods allows description of new fungal species. Summary The available data for NAFI during CGD are limited and based on case reports and small series. Invasive tissue biopsies and advanced molecular methods are often required for diagnosis and guiding antifungal strategy in addition to a close collaboration between clinician, pathologist, and mycologist. . . . . Keywords Invasive fungal disease Chronic granulomatous diseases Trichosporon inkin Phellinus tropicalis Rasamsonia . . argillacea Breakthrough infections Pediatric patients Introduction deficiency, CGD patients have the highest incidence of fungal infection among primary immunodeficiencies that Chronic granulomatous disease (CGD) is a primary immu- http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Fungal Infection Reports Springer Journals

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References (82)

Publisher
Springer Journals
Copyright
Copyright © 2019 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Infectious Diseases; Internal Medicine; Tropical Medicine; Occupational Medicine/Industrial Medicine; Pneumology/Respiratory System
ISSN
1936-3761
eISSN
1936-377X
DOI
10.1007/s12281-019-00339-5
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Management of Aspergillus infection in chronic granulomatous disease (CGD) patients remains a challenge even in new azoles era. However, epidemiology, diagnosis, and management of non-Aspergillus fungal infection (NAFI) in CGD setting are poorly described. Recent Findings NAFI appears to be rare in CGD patients and receiving antifungal prophylaxis. Clinical presentation is not specific of fungal species and patients often suffer from mild disease with prolonged course. While candidiasis and mucormycosis are also common in other immunocompromised population, infections caused by Phellinus tropicalis, Trichosporon inkin,and Rasamsonia argillacea have a unique predilection for CGD patients. Improved fungal identification with molecular methods allows description of new fungal species. Summary The available data for NAFI during CGD are limited and based on case reports and small series. Invasive tissue biopsies and advanced molecular methods are often required for diagnosis and guiding antifungal strategy in addition to a close collaboration between clinician, pathologist, and mycologist. . . . . Keywords Invasive fungal disease Chronic granulomatous diseases Trichosporon inkin Phellinus tropicalis Rasamsonia . . argillacea Breakthrough infections Pediatric patients Introduction deficiency, CGD patients have the highest incidence of fungal infection among primary immunodeficiencies that Chronic granulomatous disease (CGD) is a primary immu-

Journal

Current Fungal Infection ReportsSpringer Journals

Published: May 2, 2019

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