Nicotine reinforcement in rats with histories of cocaine self-administration

Nicotine reinforcement in rats with histories of cocaine self-administration 213 121 121 2 2 M. Tessari E. Valerio C. Chiamulera P. M. Beardsley Glaxo Research Laboratories via Fleming 2 I-37100 Verona Italy Department of Pharmacology and Toxicology Medical College of Virginia PO Box 613 23298-0613 Richmond VA USA Abstract Few reports have described conditions under which nicotine self-administration occurs in rats. In this study, rats which initially lever pressed for cocaine infusion (0.05 mg/kg) during 1 h experimental sessions continued to obtain similar infusion numbers when nicotine (0.03 mg/kg) was available. When saline was substituted for nicotine, infusions decreased from 11.8±4.5/h to 5.4±1.1/h but returned to pre-saline levels when it was reintroduced (12.0±5.5/h). These results indicate that nicotine can serve as a positive reinforcer for rats under the historical and schedule conditions described. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Nicotine reinforcement in rats with histories of cocaine self-administration

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Publisher
Springer Journals
Copyright
Copyright © 1995 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/BF02245640
Publisher site
See Article on Publisher Site

Abstract

213 121 121 2 2 M. Tessari E. Valerio C. Chiamulera P. M. Beardsley Glaxo Research Laboratories via Fleming 2 I-37100 Verona Italy Department of Pharmacology and Toxicology Medical College of Virginia PO Box 613 23298-0613 Richmond VA USA Abstract Few reports have described conditions under which nicotine self-administration occurs in rats. In this study, rats which initially lever pressed for cocaine infusion (0.05 mg/kg) during 1 h experimental sessions continued to obtain similar infusion numbers when nicotine (0.03 mg/kg) was available. When saline was substituted for nicotine, infusions decreased from 11.8±4.5/h to 5.4±1.1/h but returned to pre-saline levels when it was reintroduced (12.0±5.5/h). These results indicate that nicotine can serve as a positive reinforcer for rats under the historical and schedule conditions described.

Journal

PsychopharmacologySpringer Journals

Published: Sep 1, 1995

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