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Curr Breast Cancer Rep (2017) 9:13–25 DOI 10.1007/s12609-017-0231-1 TRANSLATIONAL RESEARCH (TA KING AND EA MITTENDORF, SECTION EDITORS) New Insights in Estrogen Receptor (ER) Biology and Implications for Treatment 1 1,2 Aabha Oza & Cynthia X. Ma Published online: 14 February 2017 Springer Science+Business Media New York 2017 Abstract insight toward improving individualized treatment strategies Purpose of Review Estrogen receptor-positive (ER+) breast for patients with ER+ breast cancer. cancer represents the majority of breast cancer diagnoses . . and is the leading cause of cancer death in women. Keywords Estrogen receptor Endocrine therapy CDK4/6 . . . Endocrine therapy is the principal treatment strategy for inhibitor mTOR inhibitor Targeted therapy ESR1 ER+ breast cancer. However, resistance to endocrine therapy, either de novo or acquired, is commonly observed, resulting in disease relapse and progression. This review will focus on Introduction recent progress in our understanding of ER biology and the implications for treatments. Endocrine therapy began over 100 years ago with the histor- Recent Findings Advances in genomic technology and labo- ical discovery by Beatson in the nineteenth century that re- ratory investigations have led to the identification of somatic moval of ovaries shrank the breast tumor [1]. Since then, oo-
Current Breast Cancer Reports – Springer Journals
Published: Feb 14, 2017
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