Neuronal and glial localization of NMDA receptors in the cerebral cortex

Neuronal and glial localization of NMDA receptors in the cerebral cortex The crucial role of glutamate receptors of theN-methyl-d-aspartate (NMDA) type in many fundamental cortical functions has been firmly established, as has its involvement in several neuropsychiatric diseases, but until recently, very little was known of the anatomical localization of NMDA receptors in the cerebral cortex of mammals. The recent application of molecular biological techniques to the study of NMDA receptors has allowed the production of specific tools, the use of which has much increased our understanding of the localization of NMDA receptors in the cerebral cortex. In particular, immunocytochemical studies on the distribution of cortical NMDA receptors have: 1. Demonstrated the preferential localization of NMDA receptors in dendritic spines, in line with previous work; 2. Disclosed a thus far unknown fraction of presynaptic NMDA receptors on both excitatory and inhibitory axon terminals; and 3. Shown that cortical astrocytes express NMDA receptors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Neurobiology Springer Journals

Neuronal and glial localization of NMDA receptors in the cerebral cortex

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Publisher
Springer Journals
Copyright
Copyright © 1997 by Humana Press Inc
Subject
Life Sciences; Neurobiology; Neurology; Cell Biology
ISSN
0893-7648
eISSN
1559-1182
D.O.I.
10.1007/BF02740618
Publisher site
See Article on Publisher Site

Abstract

The crucial role of glutamate receptors of theN-methyl-d-aspartate (NMDA) type in many fundamental cortical functions has been firmly established, as has its involvement in several neuropsychiatric diseases, but until recently, very little was known of the anatomical localization of NMDA receptors in the cerebral cortex of mammals. The recent application of molecular biological techniques to the study of NMDA receptors has allowed the production of specific tools, the use of which has much increased our understanding of the localization of NMDA receptors in the cerebral cortex. In particular, immunocytochemical studies on the distribution of cortical NMDA receptors have: 1. Demonstrated the preferential localization of NMDA receptors in dendritic spines, in line with previous work; 2. Disclosed a thus far unknown fraction of presynaptic NMDA receptors on both excitatory and inhibitory axon terminals; and 3. Shown that cortical astrocytes express NMDA receptors.

Journal

Molecular NeurobiologySpringer Journals

Published: Nov 1, 2007

References

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