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Neonatal morbidity and placental pathology

Neonatal morbidity and placental pathology Objective : To investigate the association between gestational age, placental pathology and outcome among preterm births. Methods : Medical records and placental pathology results of 165 preterm infants (gestational age ≤34 weeks) were used to analyze the development of intraventricular hemorrhage (IVH), bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), patent ductus arteriosus (PDA) and sepsis, in association with placental findings in the gestational age categories of 22–27 (n=71) and 28–33 (n=93) weeks. Results : Significant differences were found in placental findings based on gestational age and neonatal morbidity. Lower gestational age was associated with increased infection-related lesions such as chorionic vasculitis (47.9%, P<0.001) and acute chorioamnionitis (67.6%, P<0.001). Placental lesions reflecting disturbances of fetal-placental blood flow (infarction, chorionic plate thrombi and basal perivillous fibrin) were predominantly seen in the 28–33 week gestational age category (P<0.05–0.01). Despite the high prevalence of chorioamnionitis (38.8%), no significant association was found between this lesion and the tested preterm morbidity after controlling for gestational age. Only, villous edema and chorionic vasculitis were identified as independent predictors for the development of IVH (49.2%, OR A 2.57, 95% CI 1.01, 6.58 and 39.3%, OR A 1.95, 95% CI 1.01, 4.21, respectively). Conclusion : Villous edema and chorionic vasculitis are significant risk factors for the development of the IVH among neonates born at gestational age ≤34 weeks. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Indian Journal of Pediatrics Springer Journals

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References (34)

Publisher
Springer Journals
Copyright
Copyright © 2006 by Dr. K C Chaudhuri Foundation
Subject
Medicine & Public Health; Pediatrics; Gynecology
ISSN
0019-5456
eISSN
0973-7693
DOI
10.1007/BF02758255
Publisher site
See Article on Publisher Site

Abstract

Objective : To investigate the association between gestational age, placental pathology and outcome among preterm births. Methods : Medical records and placental pathology results of 165 preterm infants (gestational age ≤34 weeks) were used to analyze the development of intraventricular hemorrhage (IVH), bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), patent ductus arteriosus (PDA) and sepsis, in association with placental findings in the gestational age categories of 22–27 (n=71) and 28–33 (n=93) weeks. Results : Significant differences were found in placental findings based on gestational age and neonatal morbidity. Lower gestational age was associated with increased infection-related lesions such as chorionic vasculitis (47.9%, P<0.001) and acute chorioamnionitis (67.6%, P<0.001). Placental lesions reflecting disturbances of fetal-placental blood flow (infarction, chorionic plate thrombi and basal perivillous fibrin) were predominantly seen in the 28–33 week gestational age category (P<0.05–0.01). Despite the high prevalence of chorioamnionitis (38.8%), no significant association was found between this lesion and the tested preterm morbidity after controlling for gestational age. Only, villous edema and chorionic vasculitis were identified as independent predictors for the development of IVH (49.2%, OR A 2.57, 95% CI 1.01, 6.58 and 39.3%, OR A 1.95, 95% CI 1.01, 4.21, respectively). Conclusion : Villous edema and chorionic vasculitis are significant risk factors for the development of the IVH among neonates born at gestational age ≤34 weeks.

Journal

Indian Journal of PediatricsSpringer Journals

Published: Jan 1, 2006

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