Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/naltrexone-potentiates-the-anxiolytic-effects-of-chlordiazepoxide-in-CvlETyoRZH
References (10)
-
H. Steiner, S. Fuchs, D. Accili (1997)
D3 Dopamine Receptor-Deficient Mouse: Evidence for Reduced AnxietyPhysiology & Behavior, 63
-
M. Hooks, P. Kalivas (1994)
Involvement of dopamine and excitatory amino acid transmission in novelty-induced motor activity.The Journal of pharmacology and experimental therapeutics, 269 3
-
C. Netto, E. Cavalheiro, M. Carrasco, N. Volkmer, R. Dias, I. Izquierdo (1985)
Response of the rat brain beta-endorphin system to novelty: importance of the fornix connection.Behavioral and neural biology, 43 1
-
R. Rodgers, E. Nikulina, J. Cole (1994)
Dopamine D1 and D2 receptor ligands modulate the behaviour of mice in the elevated plus-mazePharmacology Biochemistry and Behavior, 49
-
S. Hogg (1996)
A review of the validity and variability of the Elevated Plus-Maze as an animal model of anxietyPharmacology Biochemistry and Behavior, 54
-
R. Rodgers, B. Cao, A. Dalvi, A. Holmes (1997)
Animal models of anxiety: an ethological perspective.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 30 3
-
R. Silva, R. Bellot, M. Vital, R. Frussa‐Filho (1997)
Effects of long-term ganglioside GM1 administration on a new discriminative avoidance test in normal adult mice.Psychopharmacology, 129 4
-
D. Treit, J. Menard, Cary Royan (1993)
Anxiogenic stimuli in the elevated plus-mazePharmacology Biochemistry and Behavior, 44
-
S. Pellow, P. Chopin, S. File, M. Briley (1985)
Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the ratJournal of Neuroscience Methods, 14
-
R. Rodgers, J. Randall, B. Kelway (1985)
Naloxone potentiates the depressant effect of chlordiazepoxide on spontaneous activity in miceNeuroscience Letters, 58
- Publisher
- Springer Journals
- Copyright
- Copyright © 1999 by Springer-Verlag Berlin Heidelberg
- Subject
- Legacy
- ISSN
- 0033-3158
- eISSN
- 1432-2072
- DOI
- 10.1007/s002130051157
- Publisher site
- See Article on Publisher Site
Abstract
Rationale: Both novelty and naloxone have been reported to modify the anxiolytic-like effect of benzodiazepines in the elevated plus maze. In addition, it has been largely demonstrated that novelty alters endogenous opioid activity. Objectives: The present study was designed to examine a possible interaction between novelty and naltrexone effects on the behavior of chlordiazepoxide-treated rats in two animal models of anxiety. Methods: Thirty minutes after acute intraperitoneal treatment with saline or naltrexone and saline or chlordiazepoxide, male Wistar rats were exposed for the first time to the elevated plus maze apparatus or the social interaction arena for the quantification of the percentage of time spent in the open arms or the time of active social interaction, respectively. The effects of naltrexone and/or chlordiazepoxide on the plus maze and the social interaction tests were also evaluated after previous exposure to the respective apparatus. Results: Naltrexone dose dependently increased the percentage of time spent in the open arms of the elevated plus maze in chlordiazepoxide-treated (5 mg/kg i.p.) rats exposed for the first time to the apparatus. Similarly, naltrexone (5 mg/kg i.p.) increased the time spent in active social interaction by chlordiazepoxide-treated rats exposed to an unfamiliar arena. In both experiments, naltrexone had no effect when administered alone. When both the plus maze and the social interaction tests were conducted after previous exposure to the respective apparatus, naltrexone did not modify the behavior of chlordiazepoxide- or saline-treated rats. Conclusions: These data suggest that the anxiolytic-like effects of chlordiazepoxide can be modified by opioid mechanisms in novel environments.
Journal
Psychopharmacology – Springer Journals
Published: Nov 1, 1999