Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Mycophenolic acid/prednisolone/tacrolimus

Mycophenolic acid/prednisolone/tacrolimus Reactions 1680, p249 - 2 Dec 2017 Mycophenolic acid/prednisolone/ tacrolimus Cutaneous atypical papular CD8+ lymphoproliferative disorder: case report A 20-year-old woman developed cutaneous atypical papular CD8+ lymphoproliferative disorder at acral sites during post- transplant immunosuppressive therapy with mycophenolic acid, prednisolone and tacrolimus [routes and dosages not stated]. The woman presented with a symmetrical eruption on her hands, which she was experiencing from last 2 months. Four months prior to presentation, she underwent renal transplantation for chronic renal failure secondary to familial Mediterranean fever complicated by amyloidosis. Prior to transplantation, she received colchicine, and post- transplantation, she received mycophenolic acid, prednisolone and tacrolimus, additionally. A physical examination showed a number of asymptomatic, ill-defined, erythematous macules, and several slightly hyperkeratotic papules (2–4mm in size) on the palms, especially on the volar sites of the fingers, and a few papules on the dorsa of the hands. A symmetrical mild scaling was also present on both heels. A biopsy taken from papular lesion showed focal exocytosis of small lymphocytes, some with slightly convoluted nuclei, a dense dermal infiltration of small and medium-sized lymphocytes with slight nuclear atypia, and an admixture of numerous histiocytes. A monoclonal alkaline phosphatase/anti-alkaline phosphatase staining technique showed CD8, reactive http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Mycophenolic acid/prednisolone/tacrolimus

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017

Mycophenolic acid/prednisolone/tacrolimus

Abstract

Reactions 1680, p249 - 2 Dec 2017 Mycophenolic acid/prednisolone/ tacrolimus Cutaneous atypical papular CD8+ lymphoproliferative disorder: case report A 20-year-old woman developed cutaneous atypical papular CD8+ lymphoproliferative disorder at acral sites during post- transplant immunosuppressive therapy with mycophenolic acid, prednisolone and tacrolimus [routes and dosages not stated]. The woman presented with a symmetrical eruption on her hands, which she was experiencing from last 2...
Loading next page...
1
 
/lp/springer-journals/mycophenolic-acid-prednisolone-tacrolimus-tQ4kdonrHU

References (1)

Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-017-39180-1
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p249 - 2 Dec 2017 Mycophenolic acid/prednisolone/ tacrolimus Cutaneous atypical papular CD8+ lymphoproliferative disorder: case report A 20-year-old woman developed cutaneous atypical papular CD8+ lymphoproliferative disorder at acral sites during post- transplant immunosuppressive therapy with mycophenolic acid, prednisolone and tacrolimus [routes and dosages not stated]. The woman presented with a symmetrical eruption on her hands, which she was experiencing from last 2 months. Four months prior to presentation, she underwent renal transplantation for chronic renal failure secondary to familial Mediterranean fever complicated by amyloidosis. Prior to transplantation, she received colchicine, and post- transplantation, she received mycophenolic acid, prednisolone and tacrolimus, additionally. A physical examination showed a number of asymptomatic, ill-defined, erythematous macules, and several slightly hyperkeratotic papules (2–4mm in size) on the palms, especially on the volar sites of the fingers, and a few papules on the dorsa of the hands. A symmetrical mild scaling was also present on both heels. A biopsy taken from papular lesion showed focal exocytosis of small lymphocytes, some with slightly convoluted nuclei, a dense dermal infiltration of small and medium-sized lymphocytes with slight nuclear atypia, and an admixture of numerous histiocytes. A monoclonal alkaline phosphatase/anti-alkaline phosphatase staining technique showed CD8, reactive

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

There are no references for this article.