Acta Neuropathologica (2018) 135:485–488 https://doi.org/10.1007/s00401-018-1820-4 CORRESPONDENCE Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway 1 1 1,2 1,3 1,3 Melike Pekmezci · Meredith Stevers · Joanna J. Phillips · Jessica Van Ziffle · Boris C. Bastian · 4 5 6 1 1,2 Nadejda M. Tsankova · Bette K. Kleinschmidt‑DeMasters · Marc K. Rosenblum · Tarik Tihan · Arie Perry · 1,3 David A. Solomon Received: 18 January 2018 / Revised: 5 February 2018 / Accepted: 6 February 2018 / Published online: 10 February 2018 © Springer-Verlag GmbH Germany, part of Springer Nature 2018 Initially described in 2013, multinodular and vacuolating and all pathologically proven cases have reportedly followed neuronal tumor of the cerebrum (MVNT) is a low-grade a benign clinical course to date [1, 8, 11]. The molecular neuronal neoplasm of the cerebral hemispheres composed basis of MVNT is unknown, and some authors have sug- of small to medium sized neuronal cells arranged in nod- gested that MVNT is a malformative lesion rather than a ules involving the deep cortex and subcortical white mat- true clonal neoplasm [4, 13]. ter, showing prominent intracytoplasmic and stromal vacu- To investigate the molecular pathogenesis of MVNT, we olation . The tumor cells are typically immunopositive assembled a cohort of archival tissue specimens from
Acta Neuropathologica – Springer Journals
Published: Feb 10, 2018
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