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Monoamine oxidase activity and enzyme kinetics in three subpopulations of density-fractionated platelets in chronic paranoid schizophrenics

Monoamine oxidase activity and enzyme kinetics in three subpopulations of density-fractionated... 213 74 74 4 4 J. John Mann Richard D. Kaplan Anastase Georgotas Eitan Friedman Marc Branchey Samuel Gershon Payne Whitney Clinic New York Hospital-Cornell Medical Center 525 East 68th Street 10021 New York New York USA Department of Psychiatry New York University Medical Center 550 First Avenue 10016 New York New York USA Rockland Research Institute 10962 Orangeburg New York USA Department of Psychiatry Wayne State University 48201 Detroit Michigan USA Abstract Platelet monoamine oxidase (MAO) activity was studied in three subpopulations of density-fractionated platelets in 15 unmedicated chronic paranoid schizophrenic patients and contrasted with normal controls. No significant difference in MAO activity was found in any of the three platelet fractions in schizophrenics compared to controls. Enzyme kinetic studies performed on the intermediate-density platelet fraction demonstrated no significant differences in V max or Michaelis' constant ( K m ) between schizophrenics and controls, but showed that the higher platelet MAO activity reported in females compared to male is due to a significantly greater V max rather than altered K m . It is suggested that conflicting results reported in the literature regarding platelet MAO in schizophrenia are not related to the platelet subpopulations studied but are largely due to the selected patient population. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Monoamine oxidase activity and enzyme kinetics in three subpopulations of density-fractionated platelets in chronic paranoid schizophrenics

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References (29)

Publisher
Springer Journals
Copyright
Copyright © 1981 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00432744
Publisher site
See Article on Publisher Site

Abstract

213 74 74 4 4 J. John Mann Richard D. Kaplan Anastase Georgotas Eitan Friedman Marc Branchey Samuel Gershon Payne Whitney Clinic New York Hospital-Cornell Medical Center 525 East 68th Street 10021 New York New York USA Department of Psychiatry New York University Medical Center 550 First Avenue 10016 New York New York USA Rockland Research Institute 10962 Orangeburg New York USA Department of Psychiatry Wayne State University 48201 Detroit Michigan USA Abstract Platelet monoamine oxidase (MAO) activity was studied in three subpopulations of density-fractionated platelets in 15 unmedicated chronic paranoid schizophrenic patients and contrasted with normal controls. No significant difference in MAO activity was found in any of the three platelet fractions in schizophrenics compared to controls. Enzyme kinetic studies performed on the intermediate-density platelet fraction demonstrated no significant differences in V max or Michaelis' constant ( K m ) between schizophrenics and controls, but showed that the higher platelet MAO activity reported in females compared to male is due to a significantly greater V max rather than altered K m . It is suggested that conflicting results reported in the literature regarding platelet MAO in schizophrenia are not related to the platelet subpopulations studied but are largely due to the selected patient population.

Journal

Psychopharmacology – Springer Journals

Published: Sep 1, 1981

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