Access the full text.
Sign up today, get DeepDyve free for 14 days.
(1997)
Serum amineoxidase modifies the effect of ceruloplasmin on neuronal K channel currents
S. Smirnov, P. Aaronson (1992)
Ca(2+)‐activated and voltage‐gated K+ currents in smooth muscle cells isolated from human mesenteric arteries.The Journal of Physiology, 457
Y. Ohya, M. Setoguchi, K. Fujii, T. Nagao, I. Abe, M. Fujishima (1996)
Impaired action of levcromakalim on ATP-sensitive K+ channels in mesenteric artery cells from spontaneously hypertensive rats.Hypertension, 27 6
S. Kehl (1990)
4‐Aminopyridine causes a voltage‐dependent block of the transient outward K+ current in rat melanotrophs.The Journal of Physiology, 431
Y. Ohya, N. Adachi, M. Setoguchi, I. Abe, M. Fujishima (1997)
Effects of CP-060S on membrane channels in vascular smooth muscle cells from guinea pig.European journal of pharmacology, 330 1
Fiona Halliday, P. Aaronson, A. Evans, A. Gurney (1995)
The pharmacological properties of K+ currents from rabbit isolated aortic smooth muscle cellsBritish Journal of Pharmacology, 116
G. Tang, S. Hanna, Rui Wang (1999)
Effects of nicotine on K+ channel currents in vascular smooth muscle cells from rat tail arteries.European journal of pharmacology, 364 2-3
S. Smirnov, G. Knock, P. Aaronson (1998)
Effects of the 5‐lipoxygenase activating protein inhibitor MK886 on voltage‐gated and Ca2+‐activated K+ currents in rat arterial myocytesBritish Journal of Pharmacology, 124
S. Smirnov, T. Robertson, J. Ward, P. Aaronson (1994)
Chronic hypoxia is associated with reduced delayed rectifier K+ current in rat pulmonary artery muscle cells.The American journal of physiology, 266 1 Pt 2
Scott Russell, N. Publicover, P. Hart, A. Carl, J. Hume, K. Sanders, B. Horowitz (1994)
Block by 4‐aminopyridine of a Kv1.2 delayed rectifier K+ current expressed in Xenopus oocytes.The Journal of Physiology, 481
C. Remillard, N. Leblanc (1996)
Mechanism of inhibition of delayed rectifier K+ current by 4‐aminopyridine in rabbit coronary myocytes.The Journal of Physiology, 491
(1994)
Levcromakaliminduced modulation of membrane potassium currents, intracellular calcium and mechanical activity in rat mesenteric artery
J. Ren, E. Karpinski, C. Benishin (1994)
Inhibition of a K+ current by beta-dendrotoxin in primary and subcultured vascular smooth muscle cells.The Journal of pharmacology and experimental therapeutics, 269 1
S. Russell, K. Overturf, B. Horowitz (1994)
Heterotetramer formation and charybdotoxin sensitivity of two K+ channels cloned from smooth muscle.The American journal of physiology, 267 6 Pt 1
D. Beech, T. Bolton (1989)
Two components of potassium current activated by depolarization of single smooth muscle cells from the rabbit portal vein.The Journal of Physiology, 418
Chuanli Xu, Yanjie Lu, G. Tang, Rui Wang (1999)
Expression of voltage-dependent K+ channel genes in mesenteric artery smooth muscle cells.American journal of physiology. Gastrointestinal and liver physiology, 277 5
Xiao-Jian Yuan, M. Tod, L. Rubin, M. Blaustein (1990)
Contrasting effects of hypoxia on tension in rat pulmonary and mesenteric arteries.The American journal of physiology, 259 2 Pt 2
R. Wang, E. Karpinski, P. Pang (1989)
Two types of calcium channels in isolated smooth muscle cells from rat tail artery.The American journal of physiology, 256 5 Pt 2
N. Ogata, H. Tatebayashi (1993)
Differential inhibition of a transient K+ current by chlorpromazine and 4‐aminopyridine in neurones of the rat dorsal root gangliaBritish Journal of Pharmacology, 109
S. Archer, E. Souil, A. Dinh-Xuan, B. Schremmer, J. Mercier, Abdelhamid Yaagoubi, L. Nguyen-Huu, H. Reeve, V. Hampl (1998)
Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes.The Journal of clinical investigation, 101 11
R. Wang, Lingyun Wu, Zunzhe Wang (1997)
The direct effect of carbon monoxide on KCa channels in vascular smooth muscle cellsPflügers Archiv, 434
Xiao-Jian Yuan, W. Goldman, M. Tod, Lewis Rubin, M. Blaustein (1993)
Ionic currents in rat pulmonary and mesenteric arterial myocytes in primary culture and subculture.The American journal of physiology, 264 2 Pt 1
K. Volk, J. Matsuda, E. Shibata (1991)
A voltage‐dependent potassium current in rabbit coronary artery smooth muscle cells.The Journal of Physiology, 439
J. Hume, N. Leblanc (1989)
Macroscopic K+ currents in single smooth muscle cells of the rabbit portal vein.The Journal of Physiology, 413
Normand Leblanc, X. Wan, Pak Leung (1994)
Physiological role of Ca(2+)-activated and voltage-dependent K+ currents in rabbit coronary myocytes.The American journal of physiology, 266 6 Pt 1
Daniel Choquet, Henri Korn (1992)
Mechanism of 4-aminopyridine action on voltage-gated potassium channels in lymphocytesThe Journal of General Physiology, 99
S. Thompson (1982)
Aminopyridine block of transient potassium currentThe Journal of General Physiology, 80
T. Weidelt, W. Boldt, F. Markwardt (1997)
Acetylcholine‐induced K+ currents in smooth muscle cells of intact rat small arteries.The Journal of Physiology, 500
(1995)
Voltage-gated potassium channel genes.In: Ligand- and Voltage-gated Ion Channels
Fred Chen, D. Fedida (1998)
On the Mechanism by which 4-Aminopyridine Occludes Quinidine Block of the Cardiac K+ Channel, hKv1.5The Journal of General Physiology, 111
Lingyun Wu, M. Mateescu, Xin Wang, Xin Wang, Bruno Mondovì, Rui Wang (1996)
Modulation of K+ channel currents by serum amineoxidase in neurons.Biochemical and biophysical research communications, 220 1
Voltage-dependent K+ (Kv) channels were studied in smooth muscle cells (SMCs) freshly isolated from rat mesenteric arteries. A delayed outward rectifier Kv current (I K) with a weak voltage dependence was identified. The amplitude of I K, but not its inactivation kinetics, was inhibited by 4-aminopyridine (4-AP) (IC50, 5.1 ± 0.9 mm). The inhibitory effect of 4-AP was not use-dependent, and the unbinding of 4-AP from I K channels was complete in the absence of depolarization stimuli, suggesting the binding of 4-AP to the closed state of Kv channels. There was no change in the steady-state inactivation, but the steady-state activation curve of I K was shifted in the presence of 4-AP by +6 mV. Including 4-AP in pipette solution instantly inhibited I K upon the rupture of cell membrane, indicating that 4-AP bound to the inner mouth of Kv channel pores. Several Kv channel proteins encoding the native I K-type Kv channels, but not the transient outward A-type Kv channels, were identified. Among the identified I K-encoding gene transcripts, the expression of Kv1.5 was the most abundant. Our results elucidate the modulating mechanisms for the 4-AP-induced I K inhibition in rat mesenteric artery SMCs and suggest that the unique properties of Kv channels in these cells might be related to the heteromeric expression of the I K-encoding genes with Kv1.5 subunit playing an important role.
The Journal of Membrane Biology – Springer Journals
Published: Mar 15, 2001
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.