Modification of Colonic Fermentation by Bifidobacteria and pH In Vitro (Impact on Lactose Metabolism, Short-Chain Fatty Acid, and Lactate Production)

Modification of Colonic Fermentation by Bifidobacteria and pH In Vitro (Impact on Lactose... Colonic fermentation plays an important role inthe prevention of lactose intolerance and intestinaldisorders. The objectives of this study were to evaluatewhether supplementation with bifidobacteria modify colonic fermentation of lactose andshort-chain fatty acid production and to assessinfluence of the pH in an in vitro continuous culturesystem. There was a significantly greater reduction inlactose concentrations at pH 6.7 than that at either pH6.2 or pH 5.7, accompanied by the highestβ-galactosidase activity and D-lactate production.Bifidus supplementation reduced lactose and D-lactateconcentrations and increased acetate production at pH 6.7. Thestudy demonstrates that lactose is rapidly metabolizedby colonic bacteria and lactose fermentation in vitro ispH dependent with a maximum rate at pH 6.7. Bifidobacteria supplementation may have thepotential to improve lactose fermentation and tomanipulate SCFA and lactate production. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Digestive Diseases and Sciences Springer Journals

Modification of Colonic Fermentation by Bifidobacteria and pH In Vitro (Impact on Lactose Metabolism, Short-Chain Fatty Acid, and Lactate Production)

Loading next page...
 
/lp/springer-journals/modification-of-colonic-fermentation-by-bifidobacteria-and-ph-in-vitro-dIltXP5eAm
Publisher
Springer Journals
Copyright
Copyright © 1997 by Plenum Publishing Corporation
Subject
Medicine & Public Health; Gastroenterology; Hepatology; Oncology; Transplant Surgery; Biochemistry, general
ISSN
0163-2116
eISSN
1573-2568
DOI
10.1023/A:1018895524114
Publisher site
See Article on Publisher Site

Abstract

Colonic fermentation plays an important role inthe prevention of lactose intolerance and intestinaldisorders. The objectives of this study were to evaluatewhether supplementation with bifidobacteria modify colonic fermentation of lactose andshort-chain fatty acid production and to assessinfluence of the pH in an in vitro continuous culturesystem. There was a significantly greater reduction inlactose concentrations at pH 6.7 than that at either pH6.2 or pH 5.7, accompanied by the highestβ-galactosidase activity and D-lactate production.Bifidus supplementation reduced lactose and D-lactateconcentrations and increased acetate production at pH 6.7. Thestudy demonstrates that lactose is rapidly metabolizedby colonic bacteria and lactose fermentation in vitro ispH dependent with a maximum rate at pH 6.7. Bifidobacteria supplementation may have thepotential to improve lactose fermentation and tomanipulate SCFA and lactate production.

Journal

Digestive Diseases and SciencesSpringer Journals

Published: Oct 15, 2004

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off