Neurosci. Bull. www.neurosci.cn https://doi.org/10.1007/s12264-019-00338-z www.springer.com/12264 ORIGINAL ARTICLE MicroRNA-132 in the Adult Dentate Gyrus is Involved in Opioid Addiction Via Modifying the Differentiation of Neural Stem Cells 1 1 1 1 1 1 • • • • • • Meng Jia Xuewei Wang Haolin Zhang Can Ye Hui Ma Mingda Yang 1 1 Yijing Li Cailian Cui Received: 24 April 2018 / Accepted: 10 October 2018 Shanghai Institutes for Biological Sciences, CAS 2019 Abstract MicroRNA-132 (miR-132), a small RNA that Introduction regulates gene expression, is known to promote neuroge- nesis in the embryonic nervous system and adult brain. MicroRNAs (miRs) are endogenous small (*22 nucleo- Although exposure to psychoactive substances can increase tides) noncoding RNAs that bind to the 3’ untranslated miR-132 expression in cultured neural stem cells (NSCs) region of target mRNAs to modulate the post-transcrip- and the adult brain of rodents, little is known about its role tional regulation of gene expression via controlling the in opioid addiction. So, we set out to determine the effect degradation and translation of mRNAs. The role of miRs in of miR-132 on differentiation of the NSCs and whether this the central nervous system has been widely investigated, effect is involved in
Neuroscience Bulletin – Springer Journals
Published: Feb 5, 2019
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