MicroRNA-101-3p suppresses proliferation and migration in hepatocellular carcinoma by targeting the HGF/c-Met pathway

MicroRNA-101-3p suppresses proliferation and migration in hepatocellular carcinoma by targeting... Investigational New Drugs https://doi.org/10.1007/s10637-019-00766-8 PRECLINICAL STUDIES MicroRNA-101-3p suppresses proliferation and migration in hepatocellular carcinoma by targeting the HGF/c-Met pathway 1 1 2 3 1 Yang Liu & Juan Tan & Shuangyan Ou & Jun Chen & Limin Chen Received: 24 January 2019 /Accepted: 21 March 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Summary MicroRNAs are involved in each stage of tumor development. Activation of the hepatocyte growth factor (HGF)/c- Met axis facilitates the proliferation and migration of cancer cells, and the HGF/c-MET pathway provides potential targets for anticancer treatment. However, the interaction between HGF and miRNAs in hepatocellular carcinoma (HCC) remains unknown. Previous studies have shown that miR-101 is downregulated in various types of cancer and acts as a tumor suppressor, but the role of miR-101 in HCC has not yet been well defined. Here, we show that HGF is upregulated while microRNA-101-3p is significantly downregulated in the tumor tissues of HCC. By combining bioinformatics analysis and luciferase reporter assays, we demonstrated that HGF is a direct target of miR-101. In vitro experiments indicated that miR-101 inhibits the migration and proliferation of HCC cells by targeting the HGF/c-MET axis, and in vivo studies showed that overexpressed http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Investigational New Drugs Springer Journals

MicroRNA-101-3p suppresses proliferation and migration in hepatocellular carcinoma by targeting the HGF/c-Met pathway

Loading next page...
 
/lp/springer-journals/microrna-101-3p-suppresses-proliferation-and-migration-in-2XOKQta0M1
Publisher
Springer Journals
Copyright
Copyright © 2019 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Oncology; Pharmacology/Toxicology
ISSN
0167-6997
eISSN
1573-0646
D.O.I.
10.1007/s10637-019-00766-8
Publisher site
See Article on Publisher Site

Abstract

Investigational New Drugs https://doi.org/10.1007/s10637-019-00766-8 PRECLINICAL STUDIES MicroRNA-101-3p suppresses proliferation and migration in hepatocellular carcinoma by targeting the HGF/c-Met pathway 1 1 2 3 1 Yang Liu & Juan Tan & Shuangyan Ou & Jun Chen & Limin Chen Received: 24 January 2019 /Accepted: 21 March 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Summary MicroRNAs are involved in each stage of tumor development. Activation of the hepatocyte growth factor (HGF)/c- Met axis facilitates the proliferation and migration of cancer cells, and the HGF/c-MET pathway provides potential targets for anticancer treatment. However, the interaction between HGF and miRNAs in hepatocellular carcinoma (HCC) remains unknown. Previous studies have shown that miR-101 is downregulated in various types of cancer and acts as a tumor suppressor, but the role of miR-101 in HCC has not yet been well defined. Here, we show that HGF is upregulated while microRNA-101-3p is significantly downregulated in the tumor tissues of HCC. By combining bioinformatics analysis and luciferase reporter assays, we demonstrated that HGF is a direct target of miR-101. In vitro experiments indicated that miR-101 inhibits the migration and proliferation of HCC cells by targeting the HGF/c-MET axis, and in vivo studies showed that overexpressed

Journal

Investigational New DrugsSpringer Journals

Published: Mar 30, 2019

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off