Investigational New Drugs https://doi.org/10.1007/s10637-019-00766-8 PRECLINICAL STUDIES MicroRNA-101-3p suppresses proliferation and migration in hepatocellular carcinoma by targeting the HGF/c-Met pathway 1 1 2 3 1 Yang Liu & Juan Tan & Shuangyan Ou & Jun Chen & Limin Chen Received: 24 January 2019 /Accepted: 21 March 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Summary MicroRNAs are involved in each stage of tumor development. Activation of the hepatocyte growth factor (HGF)/c- Met axis facilitates the proliferation and migration of cancer cells, and the HGF/c-MET pathway provides potential targets for anticancer treatment. However, the interaction between HGF and miRNAs in hepatocellular carcinoma (HCC) remains unknown. Previous studies have shown that miR-101 is downregulated in various types of cancer and acts as a tumor suppressor, but the role of miR-101 in HCC has not yet been well defined. Here, we show that HGF is upregulated while microRNA-101-3p is significantly downregulated in the tumor tissues of HCC. By combining bioinformatics analysis and luciferase reporter assays, we demonstrated that HGF is a direct target of miR-101. In vitro experiments indicated that miR-101 inhibits the migration and proliferation of HCC cells by targeting the HGF/c-MET axis, and in vivo studies showed that overexpressed
Investigational New Drugs – Springer Journals
Published: Mar 30, 2019
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