Methotrexate
Abstract
Reactions 1680, p222 - 2 Dec 2017 Herpes simplex type 2 encephalitis: case report A 79-year-old man developed herpes simplex virus type-2 (HSV-2) encephalitis during treatment with methotrexate. The man, who had a history of peripheral spondyloarthritis (HLA-B27-positive), was receiving methotrexate 20 mg/week for two years [route not stated]. He was hospitalised for with a 4-day history of acute confusion, aphasia, fever and temporospatial disorientation. An EEG revealed slow wave activity....