Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Metastatic Malignant Phyllodes Tumor of the Breast: An Aggressive Disease—Analysis of 7 Cases

Metastatic Malignant Phyllodes Tumor of the Breast: An Aggressive Disease—Analysis of 7 Cases Abstract Malignant phyllodes tumor (PT) of the breast behaves aggressively and the presentation of distant metastases is varied, ranging from synchronous or short interval commonly to a decade rarely. To assess the clinical and temporal pattern of distant metastases in malignant PTs. A retrospective analysis of patients with Phyllodes tumor of the breast from January, 2001 to November, 2014. There were a total of 167 patients with PT; 49 (29 %) were malignant PT out of which 7 developed distant metastases. Detailed analysis of these 7 patients showed that mean age was 36.71 years (range 28–53 years). Three of the seven patients had additional local recurrences post lumpectomy. The procedure performed were wide local excision with muscle reconstruction (n = 1), lumpectomy (n = 1) and mastectomy (n = 5). The distant metastases were synchronous (n = 2) and other 5 had metastases developing within 2 months to 13 years. The sites for distant metastases included lung, brain, adrenal, para-aortic nodes and bone. Six patients received palliative chemotherapy (CT) and 2 also had radiation therapy for brain metastasis. Only 1 patient is alive and receiving CT and all others succumbed to the disease. Patients with malignant PT of the breast with distant metastases behave aggressively and have a dismal outcome with rare exceptions. They need multimodality therapy and close follow up. Newer targeted therapies may have a role to improve the outcome. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Indian Journal of Surgical Oncology Springer Journals

Metastatic Malignant Phyllodes Tumor of the Breast: An Aggressive Disease—Analysis of 7 Cases

Download PDF
7 pages

Loading next page...
 
/lp/springer-journals/metastatic-malignant-phyllodes-tumor-of-the-breast-an-aggressive-dtxrMq0Al6
Publisher
Springer Journals
Copyright
2015 Indian Association of Surgical Oncology
ISSN
0975-7651
eISSN
0976-6952
DOI
10.1007/s13193-015-0397-9
Publisher site
See Article on Publisher Site

Abstract

Abstract Malignant phyllodes tumor (PT) of the breast behaves aggressively and the presentation of distant metastases is varied, ranging from synchronous or short interval commonly to a decade rarely. To assess the clinical and temporal pattern of distant metastases in malignant PTs. A retrospective analysis of patients with Phyllodes tumor of the breast from January, 2001 to November, 2014. There were a total of 167 patients with PT; 49 (29 %) were malignant PT out of which 7 developed distant metastases. Detailed analysis of these 7 patients showed that mean age was 36.71 years (range 28–53 years). Three of the seven patients had additional local recurrences post lumpectomy. The procedure performed were wide local excision with muscle reconstruction (n = 1), lumpectomy (n = 1) and mastectomy (n = 5). The distant metastases were synchronous (n = 2) and other 5 had metastases developing within 2 months to 13 years. The sites for distant metastases included lung, brain, adrenal, para-aortic nodes and bone. Six patients received palliative chemotherapy (CT) and 2 also had radiation therapy for brain metastasis. Only 1 patient is alive and receiving CT and all others succumbed to the disease. Patients with malignant PT of the breast with distant metastases behave aggressively and have a dismal outcome with rare exceptions. They need multimodality therapy and close follow up. Newer targeted therapies may have a role to improve the outcome.

Journal

Indian Journal of Surgical Oncology – Springer Journals

Published: Dec 1, 2015

Keywords: surgical oncology; oncology; surgery

References

  • Malignant phyllodes tumors of the breast: a study in clinical practice
    J Majeski, J Stroud
  • Malignant phyllode tumor metastatic to the duodenum
    O Asoglu, H Karanlik, U Barbaros, H Yanar, Y Kapran, M Kecer, M Parlak
  • Adrenal metastasis of a phyllodes tumor of the breast: case report and review of the literature
    Y Collin, F Chagnon, CJ Mongeau, GL Gonzalez-Amaya, L Sideris
  • Malignant phyllodes tumor metastatic to the pancreas: a case report
    M Serikawa, T Sasaki, K Kobayashi, H Itsuki, M Kamigaki, T Minami
  • Anemia and jejuna intussusception: an unusual presentation for a metastatic phyllodes breast tumor
    SA Schechet, EP Askenasy, S Dhamne, BG Scott
  • Delayed cardiac metastasis from phyllodes breast tumor presenting as cardiogenic shock
    N Garg, N Moorthy, SK Agrawal, S Pandey, N Kumari
  • Metastatic phyllodes tumor causing small-bowel obstruction
    RJ Kelly, C Barrett, N Swan, R McDermott
  • Breast malignant phyllodes tumour metastasising to soft tissues of oral cavity
    L Suárez Roa Mde, LM Ruiz Godoy Rivera, T Vela Chávez, M Pérez Sánchez, A Meneses García
  • Challenges in management of phyllodes tumors of the breast: a retrospective analysis of 150 patients
    P Ramakant, S Chakravarthy, JA Cherian, DT Abraham, MJ Paul
  • Spontaneous regression of pulmonary metastases from a malignant phyllodes tumor
    A Sadatomo, Y Hozumi, M Shiozawa, Y Hirashima, K Koinuma, K Kurihara
  • Surgical treatment of phyllodes tumors of the breast
    B Salvadori, F Cusumano, R Bo, V Delledonne, M Grassi, D Rovini
  • Phyllodes tumours of the breast: a clinicopathological review of thirty-two cases
    CJC Moffat, SE Pinder, AR Dixon, CW Elston, RW Blamey, IO Ellis
  • Malignant phyllodes tumor of breast with lung metastases mimicking the primary
    J Kracht, A Sapino, G Bussolati
  • Osteogenic pulmonary metastases originating from a phyllodes tumour of the breast with osteosarcomatous differentiation
    SK Bhartia, P Kashyap
  • Surgical resection of phyllodes tumour: a radical approach as a safeguard against local recurrence
    RA Badwe, K Kataria, A Srivastava
  • Comprehensive characterization of malignant phyllodes tumor by whole genomic and proteomic analysis: biological implications for targeted therapy opportunities
    DL Jardim, A Conley, V Subbiah
  • Long-term outcomes of malignant phyllodes tumors patients: an institutional experience
    A Fou, FR Schnabel, D Hamele-Bena, XJ Wei, B Cheng, M Tamer
  • Pulmonary metastases 12 years after a mastectomy for borderline phyllodes tumor
    NIE Xiao-Meng, W Yang, Y Xiao-Peng