Diabetologia (2008) 51:1752–1754 DOI 10.1007/s00125-008-1038-4 RESEARCH LETTER Metabolically healthy but obese women: effect of an energy-restricted diet A. D. Karelis & V. Messier & M. Brochu & R. Rabasa-Lhoret Received: 24 January 2008 /Accepted: 4 April 2008 /Published online: 27 May 2008 Springer-Verlag 2008 Keywords Euglycaemic–hyperinsulinaemic clamp and inflammation profiles and no sign of hypertension, . . Insulin resistance Obesity Postmenopausal women despite having excessive body fatness. In fact, the metabolic profiles of MHO postmenopausal women are virtually Abbreviations indistinguishable from those of young lean women . FFM fat-free mass Interestingly, a recent longitudinal study reported that the FM fat mass protective metabolic profile observed in MHO individuals MHO metabolically healthy but obese was associated with lower incidences of type 2 diabetes and cardiovascular diseases . Moreover, evidence suggests that MHO individuals may account for as much as 20–30% of the obese population . To the Editor: A unique subset of obese individuals has An important question that seems to be unresolved is been identified that appears to be protected against obesity- whether MHO individuals would gain any metabolic related metabolic disturbances [1, 2]. These individuals, benefit from weight loss. Indeed, several studies have now known as ‘metabolically healthy
Diabetologia – Springer Journals
Published: Sep 1, 2008
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