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Menstrual migraine: what it is and does it matter?

Menstrual migraine: what it is and does it matter? The diagnostic criteria of menstrual migraine (MM), migraine related to menstruation and pure menstrual migraine, are placed in the appendix of the International Classification of Headache Disorders and are still primarily considered as research criteria that need validation. Although there is a great wealth of knowledge about the neurobiological processes underlying MM and its symptoms, the mechanisms by which an attack starts during the menstrual cycle remain baffling, and the disease is still undertreated. In this narrative review, we aim to summarize recent data on pathophysiology, epidemiology, burden of disease and treatment of MM. The vast majority of the literature focuses on the relationship between MM and hormonal factors. The role of falling in estrogen levels is believed to increase the susceptibility of blood vessels to prostaglandins, which have been implicated in neurogenic inflammation. Moreover, fluctuations of ovarian steroid hormone levels modulate calcitonin gene-related peptide in the trigeminovascular system. In addition, it has been observed that gonadal hormones modulate cortical spreading depression susceptibility in animal models. Sex hormone influences on MM affect not only the frequency and severity of headache attack but also its treatment. Understanding the mechanisms that contribute to neuroendocrine vulnerability in some women and some menstrual cycles may yield possible marker of the disease opening treatment options specifically targeting MM. An increased interest for future research on the subject will further elucidate how to manage this debilitating type of migraine. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurology Springer Journals

Menstrual migraine: what it is and does it matter?

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Publisher
Springer Journals
Copyright
Copyright © Springer-Verlag GmbH Germany, part of Springer Nature 2020
ISSN
0340-5354
eISSN
1432-1459
DOI
10.1007/s00415-020-09726-2
Publisher site
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Abstract

The diagnostic criteria of menstrual migraine (MM), migraine related to menstruation and pure menstrual migraine, are placed in the appendix of the International Classification of Headache Disorders and are still primarily considered as research criteria that need validation. Although there is a great wealth of knowledge about the neurobiological processes underlying MM and its symptoms, the mechanisms by which an attack starts during the menstrual cycle remain baffling, and the disease is still undertreated. In this narrative review, we aim to summarize recent data on pathophysiology, epidemiology, burden of disease and treatment of MM. The vast majority of the literature focuses on the relationship between MM and hormonal factors. The role of falling in estrogen levels is believed to increase the susceptibility of blood vessels to prostaglandins, which have been implicated in neurogenic inflammation. Moreover, fluctuations of ovarian steroid hormone levels modulate calcitonin gene-related peptide in the trigeminovascular system. In addition, it has been observed that gonadal hormones modulate cortical spreading depression susceptibility in animal models. Sex hormone influences on MM affect not only the frequency and severity of headache attack but also its treatment. Understanding the mechanisms that contribute to neuroendocrine vulnerability in some women and some menstrual cycles may yield possible marker of the disease opening treatment options specifically targeting MM. An increased interest for future research on the subject will further elucidate how to manage this debilitating type of migraine.

Journal

Journal of Neurology – Springer Journals

Published: Jan 28, 2020

Keywords: Burden of disease; CGRP; Estrogen; Headache; Treatment options

References

  • The international classification of headache disorders, 3rd edition
  • Menstrual migraine in a representative Dutch population sample: prevalence, disability and treatment
    Couturier, EG; Bomhof, MA; Neven, AK; van Duijn, NP
  • Characteristics of menstrual and nonmenstrual attacks in women with menstrually related migraine referred to headache centres
    Granella, F; Sances, G; Allais, G; Nappi, RE; Tirelli, A; Benedetto, C; Brundu, B; Facchinetti, F; Nappi, G
  • Incidence of migraine relative to menstrual cycle phases of rising and falling estrogen
    MacGregor, EA; Frith, A; Ellis, J; Aspinall, L; Hackshaw, A
  • Characteristics of menstrual vs nonmenstrual migraine: a post hoc, within-woman analysis of the usual-care phase of a nonrandomized menstrual migraine clinical trial
    MacGregor, EA; Victor, TW; Hu, X; Xiang, Q; Puenpatom, RA; Chen, W; Campbell, JC
  • Menstrual and nonmenstrual migraines differ in women with menstrually-related migraine
    Pinkerman, B; Holroyd, K
  • Menstrual versus non-menstrual attacks of migraine without aura in women with and without menstrual migraine
    Vetvik, KG; Benth, JŠ; MacGregor, EA; Lundqvist, C; Russell, MB
  • Headache classification committee of the International Headache Society
  • The international classification of headache disorders: 2nd edition
  • The international classification of headache disorders, 3rd edition (beta version)
  • The role of estradiol withdrawal in the etiology of menstrual migraine
    Somerville, BW
  • Migraine and reproductive hormones throughout the menstrual cycle
    Epstein, MT; Hockaday, JM; Hockaday, TD
  • Proceedings: progesterone, oestradiol and aldosterone levels in plasma during the menstrual cycle of women suffering from migraine
    Horth, CE; Wainscott, G; Neylan, C; Wilkinson, MI
  • Defining the relationship between ovarian hormones and migraine headache
    Martin, VT; Wernke, S; Mandell, K; Ramadan, N; Kao, L; Bean, J; Liu, J; Zoma, W; Rebar, R
  • Prevention of menstrual attacks of migraine: a double-blind placebo-controlled crossover study
    MacGregor, EA; Frith, A; Ellis, J; Aspinall, L; Hackshaw, A
  • Sex hormones in women with and without migraine: evidence of migraine-specific hormone profiles
    Pavlović, JM; Allshouse, AA; Santoro, NF; Crawford, SL; Thurston, RC; Neal-Perry, GS; Lipton, RB; Derby, CA
  • Ovarian hormones and chronic pain: a comprehensive review
    Hassan, S; Muere, A; Einstein, G
  • Levels of prostaglandins in human endometrium during the normal menstrual cycle
    Downie, J; Poyser, NL; Wunderlich, M
  • The neurobiology of vascular head pain
    Moskowitz, MA
  • CGRP and its receptors provide new insights into migraine pathophysiology
    Ho, TW; Edvinsson, L; Goadsby, PJ
  • Differentiation of nerve fibers storing CGRP and CGRP receptors in the peripheral trigeminovascular system
    Eftekhari, S; Warfvinge, K; Blixt, FW; Edvinsson, L
  • Calcitonin gene-related peptide: physiology and pathophysiology
    Russell, FA; King, R; Smillie, SJ; Kodji, X; Brain, SD
  • Prostaglandins in migraine: update
    Antonova, M; Wienecke, T; Olesen, J; Ashina, M
  • Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain
    Matsuda, M; Huh, Y; Ji, RR
  • Increased concentration of circulating calcitonin gene related peptide during normal human pregnancy
    Stevenson, JC; Macdonald, DW; Warren, RC; Booker, MW; Whitehead, MI
  • Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity
    Yallampalli, C; Chauhan, M; Thota, CS; Kondapaka, S; Wimalawansa, SJ
  • Hormonal influence on calcitonin gene-related peptide in man: effects of sex difference and contraceptive pills
    Valdemarsson, S; Edvinsson, L; Hedner, P; Ekman, R
  • Effects of menopausal status on circulating calcitonin gene-related peptide and adipokines: implications for insulin resistance and cardiovascular risks
    Gupta, P; Harte, A; Sturdee, DW; Sharma, A; Barnett, AH; Kumar, S; Mc Ternan, PG
  • Female sex hormones and rat dural vasodilatation to CGRP, periarterial electrical stimulation and capsaicin
    Gupta, S; Villalon, CM; Mehrotra, S; De Vries, R; Garrelds, IM; Pramod, R; Saxena, PR; MaassenVanDenBrink, A
  • Effects of female sex hormones on responses to CGRP, acetylcholine, and 5-HT in rat isolated arteries
    Gupta, S; Mehrotra, S; Villalón, C; De Vries, R; Garrelds, I; Saxena, P; Vandenbrink, AM
  • Reduced trigeminovascular cyclicity in patients with menstrually related migraine
    Ibrahimi, K; van Oosterhout, WP; van Dorp, W; Danser, AH; Garrelds, IM; Kushner, SA; Lesaffre, EM; Terwindt, GM; Ferrari, MD; van den Meiracker, AH; MaassenVanDenBrink, A
  • 17-β-Estradiol induces spreading depression and pain behavior in alert female rats
    Sandweiss, AJ; Cottier, KE; McIntosh, MI; Dussor, G; Davis, TP; Vanderah, TW; Largent-Milnes, TM
  • Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1
    Eikermann-Haerter, K; Dileköz, E; Kudo, C; Savitz, SI; Waeber, C; Baum, MJ; Ferrari, MD; van den Maagdenberg Arn, MJM; Moskowitz, MA; Ayata, C
  • Estrogen-dependent effects of 5-hydroxytryptophan on cortical spreading depression in rat: modelling the serotonin-ovarian hormone interaction in migraine aura
    Chauvel, V; Multon, S; Schoenen, J
  • Sex and the migraine brain
    Borsook, D; Erpelding, N; Lebel, A; Linnman, C; Veggeberg, R; Grant, PE; Buettner, C; Becerra, L; Burstein, R
  • Estrogen receptor-like immunoreactivity in the medullary and spinal dorsal horn of the female rat
    Amandusson, A; Hermanson, O; Blomqvist, A
  • Estrogen receptor messenger ribonucleic acid in female rat brain during the estrous cycle: a comparison with ovariectomized females and intact males
    Shughrue, PJ; Bushnell, CD; Dorsa, DM
  • Estrogenic influences in pain processing
    Amandusson, A; Blomqvist, A
  • Investigation of polymorphisms in genes involved in estrogen metabolism in menstrual migraine
    Sutherland, HG; Champion, M; Plays, A; Stuart, S; Haupt, LM; Frith, A; MacGregor, EA; Griffiths, LR
  • Genetic association and gene expression studies suggest that genetic variants in the SYNE1 and TNF genes are related to menstrual migraine
    Rodriguez-Acevedo, AJ; Smith, RA; Roy, B; Sutherland, H; Lea, RA; Frith, A; MacGregor, EA; Griffiths, LR
  • The NRP1 migraine risk variant shows evidence of association with menstrual migraine
    Pollock, CE; Sutherland, HG; Maher, BH; Lea, RA; Haupt, LM; Frith, A; MacGregor, EA; Griffiths, LR
  • Migraine and menstruation: a pilot study
    MacGregor, EA; Chia, H; Vohrah, RC; Wilkinson, M
  • Migraine without aura and reproductive life events: a clinical epidemiological study in 1300 women
    Granella, F; Sances, G; Zanferrari, C; Costa, A; Martignoni, E; Manzoni, GC
  • Sex-hormone-related events in migrainous females. A clinical comparative study between migraine with aura and migraine without aura
    Cupini, LM; Matteis, M; Troisi, E; Calabresi, P; Bernardi, G; Silvestrini, M
  • Self-reported menstrual migraine in the general population
    Vetvik, KG; MacGregor, EA; Lundqvist, C; Russell, MB
  • Prevalence of menstrual migraine: a population-based study
    Vetvik, KG; Macgregor, EA; Lundqvist, C; Russell, MB
  • Burden of migraine related to menses: results from the AMPP study
    Pavlović, JM; Stewart, WF; Bruce, CA; Gorman, JA; Sun, H; Buse, DC; Lipton, RB
  • Clinical characteristics of menstrually related and non-menstrual migraine
    Güven, B; Güven, H; Çomoğlu, S
  • Allodynia in menstrually related migraine: Score Assessment by Allodynia Symptom Checklist (ASC-12)
    Melhado, EM; Thiers Rister, HL; Belitardo, GA; de Oliveira, DR; Buttarello, A; Belucio, IS; Oliveira Marcos, JM; Tonhá Xavier, ML; Prieto Peres, MF
  • Women living together have a higher frequency of menstrual migraine
    Ferreira, KS; Guilherme, G; Faria, VR; Borges, LM; Uchiyama, AA
  • Characteristics of menstrual versus non-menstrual migraine during pregnancy: a longitudinal population-based study
    Petrovski, BÉ; Vetvik, KG; Lundqvist, C; Eberhard-Gran, M
  • Migraine prevalence during menopausal transition
    Wang, SJ; Fuh, JL; Lu, SR; Juang, KD; Wang, PH
  • Systematic review of preventive and acute treatment of menstrual migraine
    Nierenburg Hdel, C; Ailani, J; Malloy, M; Siavoshi, S; Hu, NN; Yusuf, N
  • A randomized double-blind study comparing rizatriptan, dexamethasone, and the combination of both in the acute treatment of menstrually related migraine
    Bigal, M; Sheftell, F; Tepper, S; Tepper, D; Ho, TW; Rapoport, A
  • Frovatriptan plus dexketoprofen in the treatment of menstrually related migraine: an open study
    Allais, G; Rolando, S; Schiapparelli, P; Airola, G; Borgogno, P; Mana, O; Benedetto, C
  • Migraine and cardiovascular disease: systematic review and meta-analysis
    Schurks, M; Rist, PM; Bigal, ME; Buring, JE; Lipton, RB; Kurth, T
  • Oral contraceptives and ischemic stroke risk
    Carlton, C; Banks, M; Sundararajan, S
  • Hormonal contraceptives and risk of ischemic stroke in women with migraine: a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC)
    Sacco, S; Merki-Feld, GS; Ægidius, KL; Bitzer, J; Canonico, M; Kurth, T; Lampl, C; Lidegaard, Ø; MacGregor, EA; MaassenVanDenBrink, A; Mitsikostas, DD; Nappi, RE; Ntaios, G; Sandset, PM; Martelletti, M
  • Effectiveness of the progestin-only pill for migraine treatment in women: a systematic review and meta-analysis
    Warhurst, S; Rofe, CJ; Brew, BJ; Bateson, D; McGeechan, K; Merki-Field, GS; Garrick, R; Tomlinson, SE
  • Randomized, controlled trial of phytoestrogen in the prophylactic treatment of menstrual migraine
    Burke, BE; Olson, RD; Cusack, BJ
  • Phyto-oestrogens in the prophylaxis of menstrual migraine
    Ferrante, F; Fusco, E; Calabresi, P; Cupini, LM
  • Non-invasive vagus nerve stimulation (nVNS) as mini-prophylaxis for menstrual/menstrually related migraine: an open-label study
    Grazzi, L; Egeo, G; Calhoun, AH; McClure, CK; Liebler, E; Barbanti, P
  • Extended cycle combined oral contraceptives and prophylactic frovatriptan during the hormone-free interval in women with menstrual-related migraines
    Coffee, AL; Sulak, PJ; Hill, AJ; Hansen, DJ; Kuehl, TJ; Clark, JW
  • Botulinum toxin a valuable prophylactic agent for migraines and a possible future option for the prevention of hormonal variations-triggered migraines
    Dima, L; Bălan, A; Moga, MA; Dinu, CG; Dimienescu, OG; Varga, I; Neculau, AE
  • Randomized controlled trial of the CGRP receptor antagonist telcagepant for prevention of headache in women with perimenstrual migraine
    Ho, TW; Ho, AP; Ge, YJ; Assaid, C; Gottwald, R; MacGregor, EA; Mannix, LK; van Oosterhout, WP; Koppenhaver, J; Lines, C; Ferrari, MD; Michelson, D
  • A controlled trial of erenumab for episodic migraine
    Goadsby, PJ; Reuter, U; Hallström, Y; Broessner, G; Bonner, JH; Zhang, F; Sapra, S; Picard, H; Mikol, DD; Lenz, RA
  • Evaluation of galcanezumab for the prevention of episodic migraine: the EVOLVE-1 randomized clinical trial
    Stauffer, VL; Dodick, DW; Zhang, Q; Carter, JN; Ailani, J; Conley, RR
  • Effect of fremanezumab compared with placebo for prevention of episodic migraine: a randomized clinical trial
    Dodick, DW; Silberstein, SD; Bigal, ME; Yeung, PP; Goadsby, PJ; Blankenbiller, T; Grozinski-Wolff, M; Yang, R; Ma, Y; Aycardi, E
  • Safety and efficacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent episodic migraine: a randomised, double-blind, placebo-controlled, exploratory phase 2 trial
    Dodick, DW; Goadsby, PJ; Silberstein, SD; Lipton, RB; Olesen, J; Ashina, M; Wilks, K; Kudrow, D; Kroll, R; Kohrman, B; Bargar, R; Hirman, J; Smith, J
  • Therapeutic novelties in migraine: new drugs, new hope?
    Do, TP; Guo, S; Ashina, M