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Megakaryocytopoiesis was evaluated in beige and pallid mice, two strains with platelet storage pool deficiency (SPD). The purpose was to determine if the known deficiency of platelet dense body contents would be associated with evidence for abnormalities of the production or regulation of megakaryocytes. Platelet number and size were normal. Megakaryocyte number and ploidy were normal. Mature megakaryocytes in beige mice were slightly larger than those of control C57BI/6J mice. Megakaryocyte size was normal in pallid mice. No other haemopoietic abnormality was detected in either strain. These findings indicated that there is a mild abnormality of megakaryocyte growth in beige mice. However, this could not be attributed solely to the SPD as it was not present in pallid mice.
Comparative Clinical Pathology – Springer Journals
Published: Jul 21, 2005
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