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213 64 64 1 1 R. Brus Z. S. Herman R. Szkilnik J. Zabawska Department of Pharmacology Biological-Physiological Institute of the Silesian School of Medicine in Katowice Marksa 38 41-808 Zabrze Poland Abstract Ten days after administration of 5,6-dihydroxytryptamine, which causes degeneration of central serotoninergic neurons, the depressive behavioral effects of PGF 2α and PGE 2 were evidently inhibited. Central chemical serotoninectomy abolished the hyperthermic and hypertensive effects of PGF 2α , but only slightly affected those of PGE 2 . It is concluded that serotoninergic neurons mediate the depressive behavioral action of both PGF 2α and PGE 2 . They also mediate the hyperthermic and hypertensive action of PGF 2α but not of PGE 2 . This suggests that these prostaglandins have different central modes of action.
Psychopharmacology – Springer Journals
Published: Jan 1, 1979
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