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Margaret Buckingham, discoveries in skeletal and cardiac muscle development, elected to the National Academy of Science

Margaret Buckingham, discoveries in skeletal and cardiac muscle development, elected to the... Margaret Buckingham was presented as a newly elected member to the National Academy of Sciences on 28 April 2012. Over the course of her career, Dr Buckingham made many seminal contributions to the understanding of skeletal muscle and cardiac development. Her studies on cardiac progenitor populations has provided insight into understanding heart malformations, while her work on skeletal muscle progenitors has elucidated their embryonic origins and the transcriptional hierarchies controlling their developmental progression. Keywords: National Academy of Sciences, Cardiac development, Skeletal muscle development Commentary Her work on cardiac progenitor populations is of clinical Dr Margaret Buckingham, a much-respected investigator importance in understanding heart malformations. who has made many significant contributions to our Dr Buckingham has also made major contributions to understanding of skeletal muscle and cardiac develop- the molecular genetic analysis of skeletal muscle devel- ment, was elected to the National Academy of Sciences in opment. She was the first to analyze expression of the 2011 and presented on 28 April, 2012. Dr Buckingham is myogenic regulatory factors of the MyoD family during Professor in the Department of Developmental Biology at mouse embryogenesis [9] and the behavior of cells in the the Pasteur Institute in Paris. She has been awarded many absence of Myf5 [10]. prestigious distinctions including that of Officier de la Lé- Her more recent work demonstrated that skeletal gion d’Honneur and Officier de l'Ordre National du Mér- muscle growth depends on a somite-derived population of ite, to name but two. progenitor cells that express Pax3 and Pax7 [11]. She Dr Buckingham’s early studies involved the cloning and established that the Myf5 gene is activated by Pax3 characterization of actin and myosin genes from cardiac through specific regulatory elements [12], and that Pax3 and skeletal muscle [1-4]. She has made seminal contribu- regulation of FGF signaling affects the balance between tions to our understanding of cardiac development. She progenitor self-renewal and differentiation [13]. She identified the second heart field [5] and showed its im- showed genetically that before cells acquire myogenic po- portant contribution to the poles of the heart. These car- tential, the equilibrium between Pax3 and Foxc2 expres- diac progenitors are regulated by a distinct genetic sion in the somite regulates the choice between myogenic network and in this context, Dr Buckingham has worked versus vascular cell fate [14]. After demonstrating the key on the role of fibroblast growth factor (FGF) signaling in role of satellite cells in adult muscle regeneration [15], she the formation of the outflow tract and pharyngeal arteries investigated satellite-cell quiescence, showing recently that [6]. Her studies of cardiac development revealed that that microRNA31 targets Myf5 mRNA, and that both are two cell lineages contribute to the myocardium [7]. sequestered in micro-ribonucleoprotein granules which Lineage studies also demonstrated a clonal relationship breakdown on satellite cell activation [16]. She also identi- between arterial pole myocardium and head muscles [8]. fied microRNA-27 as a regulator of Pax3 production [17]. Dr Buckingham’s election to the academy recognizes her many significant contributions as a leading scholar in Correspondence: mrudnicki@ohri.ca the molecular genetic study of striated muscle formation. Ottawa Hospital Research Institute, Ottawa, Ontario K1H 8L6 Canada © 2012 Rudnicki; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Rudnicki Skeletal Muscle 2012, 2:12 Page 2 of 2 http://www.skeletalmusclejournal.com/content/2/1/12 Competing interests The author declares no competing interests. Received: 17 May 2012 Accepted: 7 June 2012 Published: 7 June 2012 References 1. Minty AJ, Alonso S, Caravatti M, Buckingham ME: A fetal skeletal muscle actin mRNA in the mouse and its identity with cardiac actin mRNA. Cell 1982, 30:185–192. 2. Robert B, Daubas P, Akimenko MA, Cohen A, Garner I, Guénet J-L, Buckingham M: A single locus in the mouse encodes both myosin light chains 1 and 3, a second locus corresponds to a related pseudogene. Cell 1984, 39:129–140. 3. Robert B, Barton P, Minty A, Daubas P, Weydert A, Bonhomme F, Catalan J, Chazottes D, Guénet J-L, Buckingham M: Investigation of genetic linkage between myosin and actin genes using an interspecific mouse back-cross. Nature 1985, 314:181–183. 4. Weydert A, Barton P, Harris AJ, Pinset C, Buckingham M: Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro. Cell 1987, 49:121–129. 5. Kelly R, Brown N, Buckingham M: The arterial pole of the mouse heart forms from Fgf10 expressing precursor cells in pharyngeal mesoderm. Dev Cell 2001, 1:435–440. 6. Watanabe Y, Miyagawa-Tomita S, Vincent SD, Kelly RG, Moon AM, Buckingham ME: Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. Circ Res 2010, 106:495–503. 7. Meilhac SM, Esner M, Kelly RG, Nicolas J-F, Buckingham ME: The clonal origin of myocardial cells in different regions of the embryonic mouse heart. Dev Cell 2004, 6:1–20. 8. Lescroat F, Meilhac SM, Le Garrec JF, Nicolas JF, Kelly RG, Buckingham M: Clonal analysis reveals common lineage relationships between head muscles and second heart field derivatives in the mouse embryo. Development 2010, 137:3269–3279. 9. Sassoon D, Lyons G, Wright WE, Lin V, Lassar A, Weintraub H, Buckingham M: Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis. Nature 1989, 341:303–307. 10. Tajbakhsh S, Rocancourt D, Buckingham M: Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice. Nature 1996, 384:266–270. 11. Relaix F, Rocancourt D, Mansouri A, Buckingham MA: A Pax3/Pax7- dependent population of skeletal muscle progenitor cells. Nature 2005, 2005:435,948–953. 12. Bajard L, Relaix F, Lagha M, Rocancourt D, Daubas P, Buckingham ME: A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb. Genes Dev 2006, 20:2450–2464. 13. Lagha M, Kormish JD, Rocancourt D, Manceau M, Epstein JA, Zaret KS, Relaix F, Buckingham ME: Pax3 regulation of FGF signaling as embryonic progenitor cells progress into the myogenic program. Genes Dev 2008, 22:1828–1837. 14. Lagha M, Brunelli S, Messina G, Kume T, Relaix F, Buckingham ME: Pax3/7: Foxc2 reciprocal repression in the somite modulates multipotent stem cell fates. Dev Cell 2009, 17:892–899. 15. Montarras D, Morgan J, Collins C, Relaix F, Zaffran S, Cumano A, Partridge T, Buckingham M: Direct isolation of satellite cells for skeletal muscle regeneration. Science 2005, 309:2064–2067. Submit your next manuscript to BioMed Central 16. Crist C, Montarras D, Buckingham M: Muscle satellite cells are primed for and take full advantage of: myogenesis, but maintain quiescence with sequestration of Myf5 mRNA targeted by microRNA-31 in mRNP granules. Cell Stem Cell 2012, In Press. 17. Crist CG, Rocancourt D, Montarras D, Buckingham M: Muscle stem cell • Convenient online submission behaviour is modified by microRNA-27 regulation of Pax3 expression. • Thorough peer review Proc Natl Acad Sci USA 2009, 106:13383–13387. • No space constraints or color figure charges doi:10.1186/2044-5040-2-12 • Immediate publication on acceptance Cite this article as: Rudnicki: Margaret Buckingham, discoveries in • Inclusion in PubMed, CAS, Scopus and Google Scholar skeletal and cardiac muscle development, elected to the National Academy of Science. Skeletal Muscle 2012 2:12. • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Skeletal Muscle Springer Journals

Margaret Buckingham, discoveries in skeletal and cardiac muscle development, elected to the National Academy of Science

Skeletal Muscle , Volume 2 (1) – Jun 7, 2012

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Springer Journals
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Copyright © 2012 by Rudnicki; licensee BioMed Central Ltd.
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Life Sciences; Cell Biology; Developmental Biology; Biochemistry, general; Systems Biology; Biotechnology
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2044-5040
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10.1186/2044-5040-2-12
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22676886
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Abstract

Margaret Buckingham was presented as a newly elected member to the National Academy of Sciences on 28 April 2012. Over the course of her career, Dr Buckingham made many seminal contributions to the understanding of skeletal muscle and cardiac development. Her studies on cardiac progenitor populations has provided insight into understanding heart malformations, while her work on skeletal muscle progenitors has elucidated their embryonic origins and the transcriptional hierarchies controlling their developmental progression. Keywords: National Academy of Sciences, Cardiac development, Skeletal muscle development Commentary Her work on cardiac progenitor populations is of clinical Dr Margaret Buckingham, a much-respected investigator importance in understanding heart malformations. who has made many significant contributions to our Dr Buckingham has also made major contributions to understanding of skeletal muscle and cardiac develop- the molecular genetic analysis of skeletal muscle devel- ment, was elected to the National Academy of Sciences in opment. She was the first to analyze expression of the 2011 and presented on 28 April, 2012. Dr Buckingham is myogenic regulatory factors of the MyoD family during Professor in the Department of Developmental Biology at mouse embryogenesis [9] and the behavior of cells in the the Pasteur Institute in Paris. She has been awarded many absence of Myf5 [10]. prestigious distinctions including that of Officier de la Lé- Her more recent work demonstrated that skeletal gion d’Honneur and Officier de l'Ordre National du Mér- muscle growth depends on a somite-derived population of ite, to name but two. progenitor cells that express Pax3 and Pax7 [11]. She Dr Buckingham’s early studies involved the cloning and established that the Myf5 gene is activated by Pax3 characterization of actin and myosin genes from cardiac through specific regulatory elements [12], and that Pax3 and skeletal muscle [1-4]. She has made seminal contribu- regulation of FGF signaling affects the balance between tions to our understanding of cardiac development. She progenitor self-renewal and differentiation [13]. She identified the second heart field [5] and showed its im- showed genetically that before cells acquire myogenic po- portant contribution to the poles of the heart. These car- tential, the equilibrium between Pax3 and Foxc2 expres- diac progenitors are regulated by a distinct genetic sion in the somite regulates the choice between myogenic network and in this context, Dr Buckingham has worked versus vascular cell fate [14]. After demonstrating the key on the role of fibroblast growth factor (FGF) signaling in role of satellite cells in adult muscle regeneration [15], she the formation of the outflow tract and pharyngeal arteries investigated satellite-cell quiescence, showing recently that [6]. Her studies of cardiac development revealed that that microRNA31 targets Myf5 mRNA, and that both are two cell lineages contribute to the myocardium [7]. sequestered in micro-ribonucleoprotein granules which Lineage studies also demonstrated a clonal relationship breakdown on satellite cell activation [16]. She also identi- between arterial pole myocardium and head muscles [8]. fied microRNA-27 as a regulator of Pax3 production [17]. Dr Buckingham’s election to the academy recognizes her many significant contributions as a leading scholar in Correspondence: mrudnicki@ohri.ca the molecular genetic study of striated muscle formation. Ottawa Hospital Research Institute, Ottawa, Ontario K1H 8L6 Canada © 2012 Rudnicki; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Rudnicki Skeletal Muscle 2012, 2:12 Page 2 of 2 http://www.skeletalmusclejournal.com/content/2/1/12 Competing interests The author declares no competing interests. Received: 17 May 2012 Accepted: 7 June 2012 Published: 7 June 2012 References 1. Minty AJ, Alonso S, Caravatti M, Buckingham ME: A fetal skeletal muscle actin mRNA in the mouse and its identity with cardiac actin mRNA. Cell 1982, 30:185–192. 2. Robert B, Daubas P, Akimenko MA, Cohen A, Garner I, Guénet J-L, Buckingham M: A single locus in the mouse encodes both myosin light chains 1 and 3, a second locus corresponds to a related pseudogene. Cell 1984, 39:129–140. 3. Robert B, Barton P, Minty A, Daubas P, Weydert A, Bonhomme F, Catalan J, Chazottes D, Guénet J-L, Buckingham M: Investigation of genetic linkage between myosin and actin genes using an interspecific mouse back-cross. Nature 1985, 314:181–183. 4. Weydert A, Barton P, Harris AJ, Pinset C, Buckingham M: Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro. Cell 1987, 49:121–129. 5. Kelly R, Brown N, Buckingham M: The arterial pole of the mouse heart forms from Fgf10 expressing precursor cells in pharyngeal mesoderm. Dev Cell 2001, 1:435–440. 6. Watanabe Y, Miyagawa-Tomita S, Vincent SD, Kelly RG, Moon AM, Buckingham ME: Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. Circ Res 2010, 106:495–503. 7. Meilhac SM, Esner M, Kelly RG, Nicolas J-F, Buckingham ME: The clonal origin of myocardial cells in different regions of the embryonic mouse heart. Dev Cell 2004, 6:1–20. 8. Lescroat F, Meilhac SM, Le Garrec JF, Nicolas JF, Kelly RG, Buckingham M: Clonal analysis reveals common lineage relationships between head muscles and second heart field derivatives in the mouse embryo. Development 2010, 137:3269–3279. 9. Sassoon D, Lyons G, Wright WE, Lin V, Lassar A, Weintraub H, Buckingham M: Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis. Nature 1989, 341:303–307. 10. Tajbakhsh S, Rocancourt D, Buckingham M: Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice. Nature 1996, 384:266–270. 11. Relaix F, Rocancourt D, Mansouri A, Buckingham MA: A Pax3/Pax7- dependent population of skeletal muscle progenitor cells. Nature 2005, 2005:435,948–953. 12. Bajard L, Relaix F, Lagha M, Rocancourt D, Daubas P, Buckingham ME: A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb. Genes Dev 2006, 20:2450–2464. 13. Lagha M, Kormish JD, Rocancourt D, Manceau M, Epstein JA, Zaret KS, Relaix F, Buckingham ME: Pax3 regulation of FGF signaling as embryonic progenitor cells progress into the myogenic program. Genes Dev 2008, 22:1828–1837. 14. Lagha M, Brunelli S, Messina G, Kume T, Relaix F, Buckingham ME: Pax3/7: Foxc2 reciprocal repression in the somite modulates multipotent stem cell fates. Dev Cell 2009, 17:892–899. 15. Montarras D, Morgan J, Collins C, Relaix F, Zaffran S, Cumano A, Partridge T, Buckingham M: Direct isolation of satellite cells for skeletal muscle regeneration. Science 2005, 309:2064–2067. Submit your next manuscript to BioMed Central 16. Crist C, Montarras D, Buckingham M: Muscle satellite cells are primed for and take full advantage of: myogenesis, but maintain quiescence with sequestration of Myf5 mRNA targeted by microRNA-31 in mRNP granules. Cell Stem Cell 2012, In Press. 17. Crist CG, Rocancourt D, Montarras D, Buckingham M: Muscle stem cell • Convenient online submission behaviour is modified by microRNA-27 regulation of Pax3 expression. • Thorough peer review Proc Natl Acad Sci USA 2009, 106:13383–13387. • No space constraints or color figure charges doi:10.1186/2044-5040-2-12 • Immediate publication on acceptance Cite this article as: Rudnicki: Margaret Buckingham, discoveries in • Inclusion in PubMed, CAS, Scopus and Google Scholar skeletal and cardiac muscle development, elected to the National Academy of Science. Skeletal Muscle 2012 2:12. • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit

Journal

Skeletal MuscleSpringer Journals

Published: Jun 7, 2012

References