Psychopharmacology (2002) 164:433–434 DOI 10.1007/s00213-002-1265-1 LETTER TO THE EDITORS Jaanus Harro Long-term partial 5-HT depletion: interference of anxiety and impulsivity? Received: 21 August 2002 / Accepted: 21 August 2002 / Published online: 24 October 2002 . Springer-Verlag 2002 In their recent letter, Green and McGregor (2002) as measures of “behavioural disinhibition” (Olausson et presented clearly and concisely the long-standing contro- al. 1999) or “index of impulsivity” (Ueno et al. 2002) versy regarding the role of 5-hydroxytryptamine (5-HT) instead of the traditional “anxiolytic”. in regulation of behaviour in animal models of anxiety. We have recently studied the effects of partial 5-HT This controversy has surfaced once again because of the depletion by a low dose of parachloroamphetamine (PCA) recent directly contradictory findings regarding the effect (Harro et al. 2001), a neurotoxin that has long-term of 3,4-methylenedioxymethamphetamine (MDMA, ecsta- effects on 5-HT that are qualitatively similar to MDMA sy) in the elevated plus-maze test, and in the significance (Murray et al. 1996). Three weeks after administration of of predictions about the long-term effects of use of 2 mg/kg PCA, 5-HT levels were reduced by 20%. PCA- MDMA-like compounds in humans. The conclusion that a treated rats displayed a clear anxiogenic-like response
Psychopharmacology – Springer Journals
Published: Dec 1, 2002
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