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M. Kisumi, J. Kato, S. Komatsubara, I. Chibata (1971)
Increase in Isoleucine Accumulation by α-Aminobutyric Acid-Resistant Mutants of Serratia marcescensApplied Microbiology, 21
M. Kisumi, S. Komatsubara, I. Chibata (1973)
Leucine accumulation by isoleucine revertants of Serratia marcescens resistant to -aminobutyric acid: lack of both feedback inhibition and repression.Journal of biochemistry, 73 1
T. Tsuchida, F. Yoshinaga, K. Kubota, H. Momose (1975)
Production of l-Valine by 2-Thiazolealanine Resistant Mutants Derived from Glutamic Acid Producing BacteriaAgricultural and biological chemistry, 39
Shigeho Ikeda, I. Fujita, F. Yoshinaga (1976)
Screening of L-Isoleucine Producers among Ethionine Resistant Mutants of L-Threonine Producing BacteriaAgricultural and biological chemistry, 40
N. Seiler (1983)
Liquid chromatographic methods for assaying polyamines using prechromatographic derivatization.Methods in enzymology, 94
M. Kisumi, S. Komatsubara, M. Sugiura, I. Chibata (1971)
Properties of isoleucine hydroxamate-resistant mutants of Serratia marcescens.Journal of general microbiology, 69 3
I. Shiio, Akemi Sasaki, S. Nakamori, K. Sano (1973)
Production of L-Isoleucine by AHV Resistant Mutants of Brevibacterium flavumAgricultural and biological chemistry, 37
M. Kisumi, S. Komatsubara, I. Chibata (1971)
Multivalent repression and genetic depression of isoleucine-valine biosynthetic enzymes in Serratia marcescens.Journal of bacteriology, 107 3
H. Yukawa, M. Terasawa (1986)
L isoleucine production by ethanol utilizing microorganismProcess Biochemistry, 21
M. Kisumi, S. Komatsubara, I. Chibata (1971)
Valine Accumulation by α-Aminobutyric Acid-Resistant Mutants of Serratia marcescensJournal of Bacteriology, 106
A new process (Living Cell Reaction Process) for l -isoleucine production using viable, non-growing cells of Brevibacterium flavum AB-07 was optimised using ethanol as the energy source and α-ketobutyric acid (α-KB) as precursor. l -valine also could be produced from glucose at high yield by this process. This process differs from the usual fermentation method in that non-growing cells are used, and the production of l -isoleucine and l -valine were carried out under conditions of repressed cell division and growth. Minimal medium missing the essential growth factor, biotin was employed as the reaction mixture for the production of l -isoleucine and l -valine. The productivity of l -isoleucine and l -valine were 200 mmol·l −1 · day −1 (molecular yield to α-KB: 95%) and 300 mmol · l −1 · day −1 (molecular yield to glucose: 80%) respectively. The content of l -isoleucine and l -valine in total amino acids produced in the each mixture were 97% and 96% respectively.
Journal of Industrial Microbiology Biotechnology – Springer Journals
Published: Jul 1, 1990
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