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Arch Dermatol Res (1998) 290 : 375–381 © Springer-Verlag 1998 ORIGINAL PAPER Hideya Ando · Atsuko Ryu · Akira Hashimoto · Masahiro Oka · Masamitsu Ichihashi Linoleic acid and á-linolenic acid lightens ultraviolet-induced hyperpigmentation of the skin Received: 8 October 1997 Abstract This study was conducted to evaluate the ef- is not possible in mammals [9, 35, 36]. The upstream fatty fects of unsaturated fatty acids on ultraviolet-induced acids of these families are oleic acid (OA, 18:1n-9), hyperpigmentation of the skin. An efficient lightening linoleic acid (LA, 18:2n-6), and a -linolenic acid (a -LNA, effect was observed following topical application of 18:3n-3), respectively (Fig. 1). UFAs and their metabo- linoleic acid or á-linolenic acid to UV-stimulated hy- lites have been used as therapeutic agents in patients with perpigmented dorsal skin of brownish guinea pigs. various skin diseases [5, 6, 34]. The physiological func- The number of melanocytes in the treated skin was tions of fatty acids in the skin have been investigated by similar to the number in the skin of the pigmented analyzing syndromes of essential fatty acid deficiency control, indicating that the pigment-lightening effect [28, 29], and early studies have shown that such deficien- was not due
Archives of Dermatological Research – Springer Journals
Published: Jul 30, 1998
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