Access the full text.
Sign up today, get DeepDyve free for 14 days.
X. Nair, K. Tramposch (1991)
The Yucatan miniature swine as an in vivo model for screening skin depigmentation.Journal of dermatological science, 2 6
E. Corey, C. Shih, J. Cashman (1983)
Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis.Proceedings of the National Academy of Sciences of the United States of America, 80 12
H. Ando, Akira Itoh, Y. Mishima, M. Ichihashi (1995)
Correlation between the number of melanosomes, tyrosinase mrna levels, and tyrosinase activity in cultured murine melanoma cells in response to various melanogenesis regulatory agentsJournal of Cellular Physiology, 163
J. Wrathall, C. Oliver, S. Silagi, E. Essner (1973)
SUPPRESSION OF PIGMENTATION IN MOUSE MELANOMA CELLS BY 5-BROMODEOXYURIDINEThe Journal of Cell Biology, 57
K. Kragballe, L. Desjarlais, J. Voorhees (1985)
Leukotrienes B4, C4 and D4 stimulate DNA synthesis in cultured human epidermal keratinocytesBritish Journal of Dermatology, 113
A. Bjørneboe, E. Søyland, GUNN‐ELIN Bjørneboe, G. Rajka, C. Drevon (1987)
Effect of dietary supplementation with eicosapentaenoic acid in the treatment of atopic dermatitisBritish Journal of Dermatology, 117
A. Allan, M. Archambault, E. Messana, B. Gilchrest (1995)
Topically applied diacylglycerols increase pigmentation in guinea pig skin.The Journal of investigative dermatology, 105 5
G. Imokawa, Y. Yada, M. Okuda (1992)
Allergic contact dermatitis releases soluble factors that stimulate melanogenesis through activation of protein kinase C-related signal-transduction pathway.The Journal of investigative dermatology, 99 4
A. Hashimoto, K. Hasegawa, Takashi Asai, Y. Masamoto, M. Ichihashi, Yutaka Mishima (1988)
Depigmenting Potency of Hydroquinone Fatty Acid Esters on the SkinThe Journal of Dermatology, 15
K. Jimbow, H. Obata, M. Pathak, T. Fitzpatrick (1974)
Mechanism of depigmentation by hydroquinone.The Journal of investigative dermatology, 62 4
S. Wright (1990)
Essential fatty acids in clinical dermatology., 1
J. Hosoi, E. Abe, T. Suda, T. Kuroki (1985)
Regulation of melanin synthesis of B16 mouse melanoma cells by 1 alpha, 25-dihydroxyvitamin D3 and retinoic acid.Cancer research, 45 4
L. Juhlin, Shelley Wb (1977)
New staining techniques for the Langerhans cell.Acta dermato-venereologica, 57 4
Chi-chung Chan, Linda Duhamel, Anthony Ford-Hutchison (1985)
Leukotriene B4 and 12-hydroxyeicosatetraenoic acid stimulate epidermal proliferation in vivo in the guinea pig.The Journal of investigative dermatology, 85 4
L. Jansen, M. Hojyo-Tomoko, A. Kligman (1974)
Improved fluorescence staining technique for estimating turnover of the human stratum corneumBritish Journal of Dermatology, 90
Michael Newman (1990)
Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids.Proceedings of the National Academy of Sciences of the United States of America, 87
S. Wright (1991)
Essential fatty acids and the skinBritish Journal of Dermatology, 125
S. Wright (1989)
Dietary Supplementation with n-6 essential fatty acids in atopic eczemaJournal of Dermatological Treatment, 1
A. Pentland, P. Needleman (1986)
Modulation of keratinocyte proliferation in vitro by endogenous prostaglandin synthesis.The Journal of clinical investigation, 77 1
Z. Friedman (1980)
Essential fatty acids revisited.American journal of diseases of children, 134 4
V. Hearing, M. Jiménez (1987)
Mammalian tyrosinase--the critical regulatory control point in melanocyte pigmentation.The International journal of biochemistry, 19 12
V. Basnayake, H. Sinclair (1954)
Skin permeability in deficiency of essential fatty acids.The Journal of physiology, 126 2
H. Ando, M. Oka, M. Ichihashi, Y. Mishima (1990)
Protein kinase C and linoleic acid-induced inhibition of melanogenesis.Pigment cell research, 3 4
Rou Riku, S. Nakatani, N. Okada, K. Yoshikawa (1993)
Growth inhibitory effect of eicosapentaenoic acid on cultured human epidermal keratinocytes.Journal of dermatological science, 5 1
K. Schallreuter, K. Lemke, H. Hill, J. Wood (1994)
Thioredoxin reductase induction coincides with melanin biosynthesis in brown and black guinea pigs and in murine melanoma cells.The Journal of investigative dermatology, 103 6
Xina Nair, Prakash Parab, Leigh Suhr, K. Tramposch (1993)
Combination of 4-hydroxyanisole and all-trans retinoic acid produces synergistic skin depigmentation in swine.The Journal of investigative dermatology, 101 2
P. Hartop, C. Prottey (1976)
Changes in transepidermal water loss and the composition of epidermal lecithin after applications of pure fatty acid triglycerides to the skin of essential fatty acid‐deficient ratsBritish Journal of Dermatology, 95
A. Bjørneboe, Anne Smith, G. Bjørneboe, Per Thune, C. Drevon (1988)
Effect of dietary supplementation with n‐3 fatty acids on clinical manifestations of psoriasisBritish Journal of Dermatology, 118
A. Hashimoto, M. Ichihashi, Y. Mishima (1984)
[The mechanism of depigmentation by hydroquinone: a study on suppression and recovery processes of tyrosinase activity in the pigment cells in vivo and in vitro].Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology, 94 7
G. Imokawa, M. Kawai (1987)
Differential hypermelanosis induced by allergic contact dermatitis.The Journal of investigative dermatology, 89 6
C. Prottey, P. Hartop, J. Black, J. Mccormack (1976)
The repair of impaired epidermal barrier function in rats by the cutaneous application of linoleic acidBritish Journal of Dermatology, 94
Arch Dermatol Res (1998) 290 : 375–381 © Springer-Verlag 1998 ORIGINAL PAPER Hideya Ando · Atsuko Ryu · Akira Hashimoto · Masahiro Oka · Masamitsu Ichihashi Linoleic acid and á-linolenic acid lightens ultraviolet-induced hyperpigmentation of the skin Received: 8 October 1997 Abstract This study was conducted to evaluate the ef- is not possible in mammals [9, 35, 36]. The upstream fatty fects of unsaturated fatty acids on ultraviolet-induced acids of these families are oleic acid (OA, 18:1n-9), hyperpigmentation of the skin. An efficient lightening linoleic acid (LA, 18:2n-6), and a -linolenic acid (a -LNA, effect was observed following topical application of 18:3n-3), respectively (Fig. 1). UFAs and their metabo- linoleic acid or á-linolenic acid to UV-stimulated hy- lites have been used as therapeutic agents in patients with perpigmented dorsal skin of brownish guinea pigs. various skin diseases [5, 6, 34]. The physiological func- The number of melanocytes in the treated skin was tions of fatty acids in the skin have been investigated by similar to the number in the skin of the pigmented analyzing syndromes of essential fatty acid deficiency control, indicating that the pigment-lightening effect [28, 29], and early studies have shown that such deficien- was not due
Archives of Dermatological Research – Springer Journals
Published: Jul 30, 1998
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.