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References (91)
-
M. Fukuda, A. Dell, J. Oates, P. Wu, J. Klock, M. Fukuda (1985)
Structures of glycosphingolipids isolated from human granulocytes. The presence of a series of linear poly-N-acetyllactosaminylceramide and its significance in glycolipids of whole blood cells.The Journal of biological chemistry, 260 2
-
S. Ho, Y. Kim (1991)
Carbohydrate antigens on cancer-associated mucin-like molecules.Seminars in cancer biology, 2 6
-
Daoud Meerzaman, Paul Shapiro, K. Kim (2001)
Involvement of the MAP kinase ERK2 in MUC1 mucin signaling.American journal of physiology. Lung cellular and molecular physiology, 281 1
-
T. Nakagoe, K. Fukushima, M. Hirota, H. Kusano, H. Ayabe, M. Tomita, S. Kamihira (1994)
An immunohistochemical employer monoclonal antibodies against Lea, sialyl Lea, Lex, and sialyl Lex antigens in primary colorectal, carcinomas and lymph node and hepatic lesionsJournal of Gastroenterology, 29
-
T., Á., Brentnall, I.., D., Bernstein (2005)
A Granulocyte Reactive Monoclonal Antibody , 1 G 1 O , Identifies the Galfll-4 ( Fucal-3 ) GlcNAc ( X Determinant ) Expressed in HL-60 Cells on Both Glycolipid and Glycoprotein Molecules -
Y. Ajioka, P. Xing, Y. Hinoda, J. Jass (2004)
Correlative histochemical study providing evidence for the dual nature of human colorectal cancer mucinThe Histochemical Journal, 29
-
N. Moniaux, Fabienne Escande, N. Porchet, Jean-Pierre Aubert, S. Batra (2001)
Structural organization and classification of the human mucin genes.Frontiers in bioscience : a journal and virtual library, 6
-
T. Goetz, Tracy Lloyd, M. Griswold (1996)
Role of E Box and Initiator Region in the Expression of the Rat Follicle-stimulating Hormone Receptor*The Journal of Biological Chemistry, 271
-
Anita Sengupta, Dimitra Valdramidou, Suzanne Huntley, Sally Hicks, Stephen Carrington, Anthony Corfield (2001)
Distribution of MUC1 in the normal human oral cavity is localized to the ducts of minor salivary glands.Archives of oral biology, 46 6
-
C. Reis, L. David, F. Carvalho, U. Mandel, C. Bolós, E. Mirgorodskaya, H. Clausen, M. Sobrinho-Simões (2000)
Immunohistochemical Study of the Expression of MUC6 Mucin and Co-expression of Other Secreted Mucins (MUC5AC and MUC2) in Human Gastric CarcinomasJournal of Histochemistry & Cytochemistry, 48
-
S. Luna-Moré, F. Ríus, B. Weil, A. Jiménez, M. Bautista, A. Pérez-Mellado (2001)
EMA: a differentiation antigen related to node metastatic capacity of breast carcinomas.Pathology, research and practice, 197 6
-
E. Philipsen, M. JØRgensen, E. Dabelsteen (1991)
Expression of blood group‐related carbohydrate antigens in normal human pancreatic tissueAPMIS, 99
-
MR Price (1988)
Epitopes of carcinoembryonic antigen (CEA) defined by monoclonal antibodies.British Journal of Cancer, 57
-
T. Itoh, S. Yonezawa, M. Nomoto, K. Ueno, Y. Kim, E. Sato (1996)
Expression of mucin antigens and Lewis X‐related antigens in carcinomas and dysplasia of the pharynx and larynxPathology International, 46
-
Daniel Podolsky (1985)
Oligosaccharide structures of isolated human colonic mucin species.The Journal of biological chemistry, 260 29
-
T. Ørntoft, N. Harving, N. Langkilde (1990)
O‐linked mucin‐type glycoproteins in normal and malignant colon mucosa: Lack of T‐antigen expression and accumulation of tn and sialosyl‐Tn antigens in carcinomasInternational Journal of Cancer, 45
-
V. Ramsauer, C. Carraway, P. Salas, K. Carraway (2003)
Muc4/Sialomucin Complex, the Intramembrane ErbB2 Ligand, Translocates ErbB2 to the Apical Surface in Polarized Epithelial Cells*Journal of Biological Chemistry, 278
-
Yi Cao, D. Blohm, B. Ghadimi, P. Stosiek, P. Xing, U. Karsten (1997)
Mucins (MUC1 and MUC3) of Gastrointestinal and Breast Epithelia Reveal Different and Heterogeneous Tumor-associated Aberrations in GlycosylationJournal of Histochemistry & Cytochemistry, 45
-
M. Therkildsen, Ulla Mandel, J. Thorn, M. Christensen, Erik Dabelsteen (1994)
Simple mucin-type carbohydrate antigens in major salivary glands.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 42
-
M. Croce, M. Isla-Larrain, F. Remes-Lenicov, A. Colussi, E. Lacunza, K. Kim, S. Gendler, A. Segal-Eiras (2006)
MUC1 cytoplasmic tail detection using CT33 polyclonal and CT2 monoclonal antibodies in breast and colorectal tissue.Histology and histopathology, 21 8
-
Bing Liu, Jessica Lague, D. Nunes, P. Toselli, F. Oppenheim, R. Soares, R. Troxler, G. Offner (2002)
Expression of Membrane-associated Mucins MUC1 and MUC4 in Major Human Salivary GlandsJournal of Histochemistry & Cytochemistry, 50
-
S. Hakomori (2004)
Carbohydrate-to-carbohydrate interaction, through glycosynapse, as a basis of cell recognition and membrane organizationGlycoconjugate Journal, 21
-
S. Gendler, J. Burchell, T. Duhig, D. Lamport, R. White, M. Parker, J. Taylor‐Papadimitriou (1987)
Cloning of partial cDNA encoding differentiation and tumor-associated mucin glycoproteins expressed by human mammary epithelium.Proceedings of the National Academy of Sciences of the United States of America, 84 17
-
M. Price, M. Sekowski, G. Yang, L. Durrant, R. Robins, R. Baldwin (2005)
Reactivity of an anti-(human gastric carcinoma) monoclonal antibody with core-related peptides of gastrointestinal mucinCancer Immunology, Immunotherapy, 33
-
Samuel Ho, G. Niehans, C. Lyftogt, P. Yan, D. Cherwitz, E. Gum, R. Dahiya, Y. Kim (1993)
Heterogeneity of mucin gene expression in normal and neoplastic tissues.Cancer research, 53 3
-
E. Dabelsteen, B. Roed-Petersen, J. Pindborg (2009)
Loss of epithelial blood group antigens A and B in oral premalignant lesions.Acta pathologica et microbiologica Scandinavica. Section A, Pathology, 83 3
-
T. Feizi, H. Gooi, R. Childs, J. Picard, K. Uemura, L. Loomes, S. Thorpe, E. Hounsell (1984)
Tumour-associated and differentiation antigens on the carbohydrate moieties of mucin-type glycoproteins.Biochemical Society transactions, 12 4
-
Shan Gao, ERIK Bennett, J. Reibel, Xinchun Chen, M. Christensen, A. Krogdahl, E. Dabelsteen (2004)
Histo‐blood group ABO antigen in oral potentially malignant lesions and squamous cell carcinoma – genotypic and phenotypic characterizationAPMIS, 112
-
J. Renkonen, T. Paavonen, R. Renkonen (1997)
Endothelial and epithelial expression of sialyl Lewisx and sialyl Lewisa in lesions of breast carcinomaInternational Journal of Cancer, 74
-
E. Dabelsteen (1996)
REVIEW ARTICLE. CELL SURFACE CARBOHYDRATES AS PROGNOSTIC MARKERS IN HUMAN CARCINOMASThe Journal of Pathology, 179
-
(2003)
Genotypic characterization of histo - blood group ABO in oral squamous cell carcinomas ( abstract ) -
V. Braga, L. Pemberton, T. Duhig, S. Gendler (1992)
Spatial and temporal expression of an epithelial mucin, Muc-1, during mouse development.Development, 115 2
-
K. Carraway, Aymee Perez, N. Idris, S. Jepson, M. Arango, M. Komatsu, B. Haq, S. Price‐Schiavi, Jin Zhang, C. Carraway (2002)
Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive.Progress in nucleic acid research and molecular biology, 71
-
N. Hanai, K. Shitara, H. Yoshida (1986)
Generation of monoclonal antibodies against human lung squamous cell carcinoma and adenocarcinoma using mice rendered tolerant to normal human lung.Cancer research, 46 9
-
E Dabelsteen, B Roed-Petersen, JJ Pindborg (1975)
Loss of epithelial blood group antigens A and B in oral premalignant lesionsActa Pathol Microbiol Immunol Scand, 83
-
U. Mandel, O. Petersen, H. Sorensen, P. Vedtofte, S. Hakomori, H. Clausen, E. Dabelsteen (1991)
Simple mucin-type carbohydrates in oral stratified squamous and salivary gland epithelia.The Journal of investigative dermatology, 97 4
-
A. Takada, K. Ohmori, T. Yoneda, K. Tsuyuoka, A. Hasegawa, M. Kiso, R. Kannagi (1993)
Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium.Cancer research, 53 2
-
S. Chang, A. Dohrman, C. Basbaum, S. Ho, T. Tsuda, N. Toribara, J. Gum, Y. Kim (1994)
Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer.Gastroenterology, 107 1
-
J. Jeannon, V. Aston, F. Stafford, J. Soames, J. Wilson (2001)
Expression of MUC1 and MUC2 glycoproteins in laryngeal cancer.Clinical otolaryngology and allied sciences, 26 2
-
P. Beum, P. Cheng (2001)
Biosynthesis and function of β 1,6 branched mucin-type glycansAdvances in Experimental Medicine and Biology, 491
-
(1999)
Identification and characterization of different subpopulations in a human lung adenocarcinoma cell line (A549). -
M. Shimizu, K. Yamauchi (1982)
Isolation and characterization of mucin-like glycoprotein in human milk fat globule membrane.Journal of biochemistry, 91 2
-
M. Croce, M. Rabassa, M. Price, A. Segal-Eiras
MUC 1 Mucin and Carbohydrate Associated Antigens as Tumor Markers in Head and Neck Squamous Cell Carcinoma -
G. Yogeeswaran, P. Salk (1981)
Metastatic potential is positively correlated with cell surface sialylation of cultured murine tumor cell lines.Science, 212 4502
-
K. Yamashita, Y. Tachibana, A. Hitoi, A. Kobata (1984)
Sialic acid-containing sugar chains of hen ovalbumin and ovomucoid.Carbohydrate research, 130
-
Y. Tatemoto, Munehisa Saka, T. Tanimura, Masahiko Mori (1987)
Immunohistochemical observations on binding of monoclonal antibody to epithelial membrane antigen in epithelial tumors of the oral cavity and skin.Oral surgery, oral medicine, and oral pathology, 64 6
-
R. Bresalier, J. Byrd, P. Brodt, S. Ogata, S. Itzkowitz, C. Yunker (1998)
Liver metastasis and adhesion to the sinusoidal endothelium by human colon cancer cells is related to mucin carbohydrate chain lengthInternational Journal of Cancer, 76
-
G. Springer (1984)
T and Tn, general carcinoma autoantigens.Science, 224 4654
-
Donald Weed, C. Gomez-Fernandez, E. Bonfante, Thomas Lee, J. Pacheco, M. Carvajal, W. Goodwin, K. Carraway (2001)
MUC4 (Sialomucin Complex) Expression in Salivary Gland Tumors and Squamous Cell Carcinoma of the Upper Aerodigestive TractOtolaryngology–Head and Neck Surgery, 124
-
David Urdal, TA Brentnall, Irwin Bernstein, Sen-itiroh Hakomori (1983)
A granulocyte reactive monoclonal antibody, 1G10, identifies the Gal beta 1-4 (Fuc alpha 1-3)GlcNAc (X determinant) expressed in HL-60 cells on both glycolipid and glycoprotein molecules.Blood, 62 5
-
J. Reibel (2003)
Prognosis of oral pre-malignant lesions: significance of clinical, histopathological, and molecular biological characteristics.Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists, 14 1
-
(1996)
Antigen heterogeneous expression in colorectal cancer -
J. Schroeder, Melissa Thompson, Melissa Gardner, S. Gendler (2001)
Transgenic MUC1 Interacts with Epidermal Growth Factor Receptor and Correlates with Mitogen-activated Protein Kinase Activation in the Mouse Mammary Gland*The Journal of Biological Chemistry, 276
-
H. Feickert, Bernd Anger, C. Cordon-Cardo, K. Lloyd (1990)
Cell‐surface antigens of human lung tumors detected by mouse monoclonal antibodies: Definition of blood‐group‐ and non‐blood‐group‐related antigenic systemsInternational Journal of Cancer, 46
-
J. Taylor‐Papadimitriou, J. Burchell, David Miles, M. Dalziel (1999)
MUC1 and cancer.Biochimica et biophysica acta, 1455 2-3
-
M. Ligtenberg, Femke Buijs, Hans Vos, John Milkens (1992)
Suppression of cellular aggregation by high levels of episialin.Cancer research, 52 8
-
S. Gendler, C. Lancaster, J. Taylor‐Papadimitriou, T. Duhig, N. Peat, J. Burchell, L. Pemberton, E. Lalani, David Wilson (1990)
Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin.The Journal of biological chemistry, 265 25
-
Sandra Gendler (2001)
MUC1, The Renaissance MoleculeJournal of Mammary Gland Biology and Neoplasia, 6
-
J. Burchell, S. Gendler, J. Taylor‐Papadimitriou, A. Girling, Angela Lewis, R. Millis, D. Lamport (1987)
Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin.Cancer research, 47 20
-
M. Bryne, J. Reibel, U. Mandel, E. Dabelsteen (1991)
Expression of mucin type carbohydrates may supplement histologic diagnosis in oral premalignant lesions.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 20 3
-
J Taylor-Papadimitriou, J Burchell, DW Miles (1999)
MUC1 and cancerBiochem Biophys Acta, 1455
-
I. Brockhausen, P. Romero, A. Herscovics (1991)
Glycosyltransferase changes upon differentiation of CaCo-2 human colonic adenocarcinoma cells.Cancer research, 51 12
-
A. Brown, Ten Feizi, H. Gooi, M. Embleton, J. Picard, Robert Baldwin (1983)
A monoclonal antibody against human colonic adenoma recognizes difucosylated Type-2-blood-group chainsBioscience Reports, 3
-
F. Hanisch, S. Müller (2000)
MUC1: the polymorphic appearance of a human mucin.Glycobiology, 10 5
-
K. Lloyd, J. Burchell, V. Kudryashov, B. Yin, J. Taylor‐Papadimitriou (1996)
Comparison of O-Linked Carbohydrate Chains in MUC-1 Mucin from Normal Breast Epithelial Cell Lines and Breast Carcinoma Cell Lines:The Journal of Biological Chemistry, 271
-
E. Dabelsteen, H. Clausen, P. Holmstrup, J. Reibel (1988)
Premalignant and malignant oral lesions are associated with changes in the glycosylation pattern of carbohydrates related to ABH blood group antigensAPMIS, 96
-
C. Reis, T. Sørensen, U. Mandel, L. David, E. Mirgorodskaya, P. Roepstorff, J. Kihlberg, John-Erik Hansen, H. Clausen (2004)
Development and characterization of an antibody directed to an α-N-acetyl-D-galactosamine glycosylated MUC2 peptideGlycoconjugate Journal, 15
-
C. Hanski, M. Hanski, T. Zimmer, D. Ogorek, P. Devine, E. Riecken (1995)
Characterization of the major sialyl-Lex-positive mucins present in colon, colon carcinoma, and sera of patients with colorectal cancer.Cancer research, 55 4
-
Lucien Perey, Daniel Hayes, Donald Kufe (1992)
Effects of differentiating agents on cell surface expression of the breast carcinoma-associated DF3-P epitope.Cancer research, 52 22
-
K. Fukushima, M. Hirota, P. Terasaki, A. Wakisaka, H. Togashi, D. Chia, N. Suyama, Y. Fukushi, E. Nudelman, S. Hakomori (1984)
Characterization of sialosylated Lewisx as a new tumor-associated antigen.Cancer research, 44 11
-
M. Croce, M. Rabassa, M. Price, A. Segal-Eiras (2009)
MUC1 mucin and carbohydrate associated antigens as tumor markers in head and neck squamous cell carcinomaPathology & Oncology Research, 7
-
Anna López-Ferrer, C. Bolós, Carlos Barranco, Marta Garrido, Joan Isern, Ingemar Carlstedt, Celso Reis, J. Torrado, Francisco Real (2000)
Role of fucosyltransferases in the association between apomucin and Lewis antigen expression in normal and malignant gastric epitheliumGut, 47
-
T. Nitta, K. Sugihara, S. Tsuyama, F. Murata (2000)
Immunohistochemical study of MUC1 mucin in premalignant oral lesions and oral squamous cell carcinomaCancer, 88
-
M. Price, Jamie Pugh, F. Hudecz, W. Griffiths, E. Jacobs, IM Symonds, A. Clarke, WC Chan, R. Baldwin (1990)
C595--a monoclonal antibody against the protein core of human urinary epithelial mucin commonly expressed in breast carcinomas.British Journal of Cancer, 61
-
Amos Baruch, M. Hartmann, Merav Yoeli, Yair Adereth, Shulamit Greenstein, Yona Stadler, Yehuda Skornik, J. Zaretsky, N. Smorodinsky, I. Keydar, D. Wreschner (1999)
The breast cancer-associated MUC1 gene generates both a receptor and its cognate binding protein.Cancer research, 59 7
-
J. Spielman, S. Hull, Z. Sheng, R. Kanterman, A. Bright, K. Carraway (1988)
Biosynthesis of a tumor cell surface sialomucin. Maturation and effects of monensin.The Journal of biological chemistry, 263 20
-
C. Reis, L. David, P. Nielsen, H. Clausen, Katja Mirgorodskaya, P. Roepstorff, M. Sobrinho-Simões (1997)
Immunohistochemical study of MUC5AC expression in human gastric carcinomas using a novel monoclonal antibodyInternational Journal of Cancer, 74
-
D. Kufe, G. Inghirami, M. Abe, D. Hayes, H. Justi-Wheeler, J. Schlom (1984)
Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors.Hybridoma, 3 3
-
T. Irimura, Denda Kaori, Shin-ichiro Iida, H. Takeuchi, Kentaro Kato (1999)
Diverse glycosylation of MUC1 and MUC2: potential significance in tumor immunity.Journal of biochemistry, 126 6
-
Bruce Fernandez, J. Lund, F. Meyers (1987)
Epithelial Membrane Antigen Expression in Benign and Malignant Squamous Epithelium of the Head and NeckOtolaryngology–Head and Neck Surgery, 97
-
M. Croce, Colussi Ag, M. Price, A. Segal-Eiras (1997)
Expression of tumour associated antigens in normal, benign and malignant human mammary epithelial tissue: a comparative immunohistochemical study.Anticancer research, 17 6D
-
Yi Cao, P. Stosiek, G. Springer, U. Karsten (1996)
Thomsen-Friedenreich-related carbohydrate antigens in normal adult human tissues: a systematic and comparative studyHistochemistry and Cell Biology, 106
-
T Nitta, K Sugihara, S Tsuyama (2000)
Immunohistochemical study of MUC1 mucin in premalignant oral lesions and oral squamous cell carcinoma: association with disease progression, mode of invasion, and lymph node metastasisCancer, 88
-
Simon Parry, Howard Silverman, Kimberly McDermott, Anthony Willis, Michael Hollingsworth, Ann Harris (2001)
Identification of MUC1 proteolytic cleavage sites in vivo.Biochemical and biophysical research communications, 283 3
-
E Dabelsteen (1996)
Cell surface carbohydrates as prognostic markers in human carcinomasJ Pathol, 179
-
Erik Dabelsteen, B. Grøn, Ulla Mandel, Ian Mackenzie (1998)
Altered expression of epithelial cell surface glycoconjugates and intermediate filaments at the margins of mucosal wounds.The Journal of investigative dermatology, 111 4
-
S. Zotter (1988)
Tissue and tumor distribution of human polymorphic epithelial mucin, 11
-
F. Levitin, Omer Stern, M. Weiss, Chava Gil-Henn, R. Ziv, Zofnat Prokocimer, N. Smorodinsky, D. Rubinstein, D. Wreschner (2005)
The MUC1 SEA Module Is a Self-cleaving Domain*Journal of Biological Chemistry, 280
-
S. Baldus, Katja Engelmann, F. Hanisch (2004)
MUC1 and the MUCs: A Family of Human Mucins with Impact in Cancer BiologyCritical Reviews in Clinical Laboratory Sciences, 41
-
Yi Cao, U. Karsten, W. Liebrich, W. Haensch, G. Springer, P. Schlag (1995)
Expression of thomsen‐friedenreich‐related antigens in primary and metastatic colorectal carcinomas. A reevaluationCancer, 76
-
F. Hanisch, G. Uhlenbruck, J. Peter-Katalinic, Heinz Egge, J. Dąbrowski, U. Dąbrowski (1989)
Structures of neutral O-linked polylactosaminoglycans on human skim milk mucins. A novel type of linearly extended poly-N-acetyllactosamine backbones with Gal beta(1-4)GlcNAc beta(1-6) repeating units.The Journal of biological chemistry, 264 2
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- Springer Journals
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- Copyright © 2007 by Arányi Lajos Foundation
- Subject
- Biomedicine; Cancer Research; Oncology; Pathology; Immunology; Biomedicine general
- ISSN
- 1219-4956
- eISSN
- 1532-2807
- DOI
- 10.1007/BF02893488
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Abstract
An immunohistochemical analysis was employed to determine the expression of carbohydrate antigens associated to mucins in normal epithelia. Tissue samples were obtained as biopsies from normal breast (18), colon (35) and oral cavity mucosa (8). The following carbohydrate epitopes were studied: sialyl-Lewis x, Lewis x, Lewis y, Tn hapten, sialyl-Tn and Thomsen-Friedenreich antigen. Mucins were also studied employing antibodies against MUC1, MUC2, MUC4, MUC5AC, MUC6 and also normal colonic glycolipid. Statistical analysis was performed and Kendall correlations were obtained. Lewis x showed an apical pattern mainly at plasma membrane, although cytoplasmic staining was also found in most samples. TF, Tn and sTn haptens were detected in few specimens, while sLewis x was found in oral mucosa and breast tissue. Also, normal breast expressed MUC1 at a high percentage, whereas MUC4 was observed in a small number of samples. Colon specimens mainly expressed MUC2 and MUC1, while most oral mucosa samples expressed MUC4 and MUC1. A positive correlation between MUC1VNTR and TF epitope (τ=0.396) was found in breast samples, while in colon specimens MUC2 and colonic glycolipid versus Lewis x were statistically significantly correlated (τ=0.28 and τ=0.29, respectively). As a conclusion, a defined carbohydrate epitope expression is not exclusive of normal tissue or a determined localization, and it is possible to assume that different glycoproteins and glycolipids may be carriers of carbohydrate antigens depending on the tissue localization considered.
Journal
Pathology & Oncology Research – Springer Journals
Published: Apr 11, 2008