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Learning impairment in the radial-arm maze following prolonged cannabis treatment in rats

Learning impairment in the radial-arm maze following prolonged cannabis treatment in rats 213 77 77 2 2 Alexander Stiglick Harold Kalant Department of Pharmacology University of Toronto M5S 2S1 Toronto Canada Addiction Research Foundation of Ontario M5S 2S1 Toronto Canada Abstract Chronic oral administration of cannabis extract to rats (daily Δ 9 tetrahydrocannabinol dose 20 mg/kg) was examined in three experiments for its residual effect on radialarm maze learning following a 1-month drug-free period. Learning a simple eight-arm maze was significantly impaired in rats treated for either 6 months (Experiment I) or 3 months (Experiment II) with the drug. In Experiment III, animals that received the extract for 3 months exhibited significant learning deficits on a much more difficult 12-arm radial maze. The results demonstrate that the deleterious effects of cannabis on radial-arm maze learning are probably due to a tendency toward increased vigilance and perseveration, possibly combined with an impaired utilization of spatial cues. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Learning impairment in the radial-arm maze following prolonged cannabis treatment in rats

Psychopharmacology , Volume 77 (2) – Jun 1, 1982

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References (20)

Publisher
Springer Journals
Copyright
Copyright © 1982 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00431932
Publisher site
See Article on Publisher Site

Abstract

213 77 77 2 2 Alexander Stiglick Harold Kalant Department of Pharmacology University of Toronto M5S 2S1 Toronto Canada Addiction Research Foundation of Ontario M5S 2S1 Toronto Canada Abstract Chronic oral administration of cannabis extract to rats (daily Δ 9 tetrahydrocannabinol dose 20 mg/kg) was examined in three experiments for its residual effect on radialarm maze learning following a 1-month drug-free period. Learning a simple eight-arm maze was significantly impaired in rats treated for either 6 months (Experiment I) or 3 months (Experiment II) with the drug. In Experiment III, animals that received the extract for 3 months exhibited significant learning deficits on a much more difficult 12-arm radial maze. The results demonstrate that the deleterious effects of cannabis on radial-arm maze learning are probably due to a tendency toward increased vigilance and perseveration, possibly combined with an impaired utilization of spatial cues.

Journal

PsychopharmacologySpringer Journals

Published: Jun 1, 1982

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